Gene-Environment Interactions (eBook, PDF)
-16%
155,99 €
Statt 185,99 €**
155,99 €
inkl. MwSt.
**Preis der gedruckten Ausgabe (Broschiertes Buch)
Sofort per Download lieferbar
Versandkostenfrei*
0 °P sammeln
-16%
155,99 €
Statt 185,99 €**
155,99 €
inkl. MwSt.
**Preis der gedruckten Ausgabe (Broschiertes Buch)
Sofort per Download lieferbar
Versandkostenfrei*

Alle Infos zum eBook verschenken
0 °P sammeln
Als Download kaufen
Statt 185,99 €**
-16%
155,99 €
inkl. MwSt.
**Preis der gedruckten Ausgabe (Broschiertes Buch)
Sofort per Download lieferbar
0 °P sammeln
Jetzt verschenken
Statt 185,99 €**
-16%
155,99 €
inkl. MwSt.
**Preis der gedruckten Ausgabe (Broschiertes Buch)
Sofort per Download lieferbar

Alle Infos zum eBook verschenken
0 °P sammeln
  • Format: PDF


Understanding the play between heredity and environment, andrelating it to disease causation, is the task of ecogenetics.Gene-Environment Interactions: Fundamentals of Ecogenetics presentsthe first comprehensive survey of this discipline, reflecting itsrelationship with toxicology, epidemiology, pharmacology, publichealth, and other medical and biological fields. Divided into four sections, the text elucidates key basic andadvanced topics: * Section 1 covers fundamentals, including the history of thediscipline, a discussion of the molecular laboratory toolscurrently available to assess…mehr

Produktbeschreibung
Understanding the play between heredity and environment, andrelating it to disease causation, is the task of ecogenetics.Gene-Environment Interactions: Fundamentals of Ecogenetics presentsthe first comprehensive survey of this discipline, reflecting itsrelationship with toxicology, epidemiology, pharmacology, publichealth, and other medical and biological fields. Divided into four sections, the text elucidates key basic andadvanced topics: * Section 1 covers fundamentals, including the history of thediscipline, a discussion of the molecular laboratory toolscurrently available to assess genotypes, using such measurements inmolecular epidemiology studies, and the statistical issues involvedin their analysis. * Section 2 focuses on a number of key genetic polymorphismsrelevant for ecogenetics, including enzymes of phase I and phase IImetabolism, enzymes involved in DNA repair, as well as receptorsand ion channels. This highlights characteristics of selected,widely studied genotypic/phenotypic differences, and allowsdiscussion of how given genetic variations can influence responsesto exogenous chemicals. * Section 3 examines gene-environment interactions through adisease-based approach, addressing how genetic polymorphisms caninfluence susceptibility to various diseases. Chapters coverimportant disease conditions such as various types of cancer,neurodegenerative diseases, cardiovascular disease, chronicpulmonary diseases, infectious diseases, diabetes, andobesity. * The final section discusses the ethical, legal, and social issuesthat arise when investigating and evaluating genetic polymorphismsin human populations, as well as the impact of ecogenetics on riskassessment, regulatory policies, and medicine and publichealth. Packed with clear examples illustrating concepts, as well asnumerous tables and figures, Gene-Environment Interactions:Fundamentals of Ecogenetics is a unique resource for a wide rangeof physicians, students, and other specialists.

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, D ausgeliefert werden.

  • Produktdetails
  • Verlag: John Wiley & Sons
  • Seitenzahl: 576
  • Erscheinungstermin: 2. März 2006
  • Englisch
  • ISBN-13: 9780471758037
  • Artikelnr.: 37342691
Autorenporträt
Lucio G. Costa, Ph.D., is professor of environmental health and toxicology at the University of Washington School of Public Health and Community Medicine. He is also director of the NIEHS-sponsored Neurotoxicology Research Core at the Center in Ecogenetics and Environmental Health. His research is focused on the study of the cellular, biochemical and molecular mechanisms involved in neurotoxicity using biochemical, molecular and imaging techniques. David L. Eaton is Professor of Environmental Health and Associate Dean for Research in the School of Public Health and Community Medicine at the University of Washington. He serves as Director of the Center for Ecogenetics and Environmental Health, and is also Deputy Director for a major NIEHS-sponsored research initiative in the area of toxicogenomics. Dr. Eaton's research interests focus on understanding how subtle genetic differences between individuals and species can result in potentially large differences in susceptibility to chemical carcinogens.
Inhaltsangabe
Foreword. Acknowledgments. Contributors. PART I. Chapter 1. Introduction (Lucio G. Costa and David L. Eaton). Chapter 2. Ecogenetics: Historical Perspectives (Gilbert S. Omenn and Arno G. Motulsky). Chapter 3. Tools of Ecogenetics (Theo K. Bammler
Federico M. Farin
and Richard P. Beyer). Chapter 4. Epidemiologic Approaches (Harvey Checkoway
Parveen Bhatti
and Anneclaire De Roos). Chapter 5. Statistical Issues in Ecogenetic Studies (Stephanie A. Monks). PART II. Chapter 6. Overview of Section II (Lucio G. Costa and David L. Eaton). Chapter 7. Polymorphisms in Cytochrome P450 and Flavin-Containing Monooxygenase Genes (Catherine K.Yeung
Allan E. Rettie
and Kenneth E. Thummel) Chapter 8. Polymorphisms in Xenobiotic Conjugation (Helen E. Smith
David L. Eaton
and Theo K. Bammler). Chapter 9. Paraoxonase
Butyrylcholinesterase
and Epoxide Hydrolase (Lucio G. Costa
Toby B. Cole
Gary K. Geiss
and Clement E. Furlong). Chapter 10. DNA Repair Enzymes (Jon P. Anderson and Lawrence A. Loeb). Chapter 11. Receptors and Ion Channels (Lucio G. Costa). PART III. Chapter 12. Overview of Section III (Lucio G. Costa and David L. Eaton). Chapter 13. Lung Cancer (Valle Nazar-Stewart). Chapter 14. Gastrointestinal Cancers (Thomas L.Vaughan). Chapter 15. Neurodegenerative Diseases (Samir N. Kelada
Harvey Checkoway
and Lucio G. Costa). Chapter 16. Cardiovascular Disease (Melissa A.Austin and Stephen M. Schwartz). Chapter 17. Type 2 Diabetes (Karen L. Edwards). Chapter 18. Infectious Disease Ecogenetics (David R. Sherman). Chapter 19. Genetic Variation
Diet
and Disease Susceptibility (Johanna W. Lampe and John D. Potter). Chapter 20. Genetic Determinants of Addiction to Alcohol
Tobacco
and Drugs of Abuse (Andrew J. Saxon). PART IV. Chapter 21. Overview of Section IV (Lucio G. Costa and David L. Eaton). Chapter 22. Ethical Issues in Ecogenetics (Kelly Fryer-Edwards
Lindsay A. Hampson
Christopher R. Carlsten
and Wylie Burke). Chapter 23. Social and Psychological Aspects of Ecogenetics (Deborah Bowen
Shirley Beresford
and Brenda Diergaarde). Chapter 24. Legal Issues (Kate Battuello and Anna Mastroianni). Chapter 25. Risk Assessment and the Impact of Ecogenetics (Elaine M. Faustman and Gilbert S. Omenn). Bibliography. Index.
Rezensionen
"...highly recommended for academic libraries that have undergraduate and graduate studies in genetics, toxicology, and pharmacology." (E-STREAMS, September 2007)

"...a great accomplishment, and it can well serve as a primary, extensively-referenced text..." (American Journal of Medical Genetics, Part A, August 1, 2007)

"...a must-have for all toxicology and pharmacology students as well as a great resource for researchers and physicians." (Environmental Health Perspectives, June 2006)

"...a vital in-office reference for any scientific researcher dedicated to the study of genetics...invaluable to public health researchers who are look at how global threats live Avian Flu might spread to the general populous...an indispensable reference to all health science libraries." (The Electric Review, March/April 2006)
"...a must-have for all toxicology and pharmacology students as well as a great resource for researchers and physicians." (Environmental Health Perspectives, June 2006)"...a vital in-office reference for any scientific researcher dedicated to the study of genetics...invaluable to public health researchers who are look at how global threats live Avian Flu might spread to the general populous...an indispensable reference to all health science libraries." (The Electric Review, March/April 2006)