Chronopharmaceutical drug delivery of Salbutamol Sulphate - Patel, Priti;Doshi, Ravi;Patel, Kanu
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The present research work is to design and evaluate an oral time dependent, pulsatile drug delivery system containing Salbutamol Sulphate, which can be targeted to time dependent manner, to modulate the drug level in synchrony with the circadian rhythm of nocturnal asthma. A time dependent pulsatile dosage form was developed by using a various grade of HPC in compressed coated layer. A pulsatile Tablet in Tablet dosage form, taken at bed time with a programmed start of drug release early in morning hours, can prevent a sharp increase in the incidence of asthmatic attacks, during the early…mehr

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Produktbeschreibung
The present research work is to design and evaluate an oral time dependent, pulsatile drug delivery system containing Salbutamol Sulphate, which can be targeted to time dependent manner, to modulate the drug level in synchrony with the circadian rhythm of nocturnal asthma. A time dependent pulsatile dosage form was developed by using a various grade of HPC in compressed coated layer. A pulsatile Tablet in Tablet dosage form, taken at bed time with a programmed start of drug release early in morning hours, can prevent a sharp increase in the incidence of asthmatic attacks, during the early morning hours (nocturnal asthma), a time when the risk of asthmatic attacks is the greatest.
Autorenporträt
Ms Priti L. Patel completed her Master and Bachelor in Pharmacy from Shri B. M. Shah College of Pharmaceutical Education and Research, Modasa.