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Discover important lessons learned about whole organism biologyvia microbial proteomics This text provides an exhaustive analysis and presentation ofcurrent research in the field of microbial proteomics, with anemphasis on new developments and applications and future directionsin research. The editors and authors show how and why the relativesimplicity of microbes has made them attractive targets forextensive experimental manipulation in a quest for both improveddisease prevention and treatment and an improved understanding ofwhole organism functional biology. In particular, the…mehr

Produktbeschreibung
Discover important lessons learned about whole organism biologyvia microbial proteomics This text provides an exhaustive analysis and presentation ofcurrent research in the field of microbial proteomics, with anemphasis on new developments and applications and future directionsin research. The editors and authors show how and why the relativesimplicity of microbes has made them attractive targets forextensive experimental manipulation in a quest for both improveddisease prevention and treatment and an improved understanding ofwhole organism functional biology. In particular, the textdemonstrates how microbial proteomic analyses can aid in drugdiscovery, including identification of new targets, noveldiagnostic markers, and lead optimization. Each chapter is written by one or more leading experts in thefield and carefully edited to ensure a consistent and thoroughapproach throughout. Methods, technologies, and tools associatedwith the most promising approaches are stressed. Key topics coveredinclude: * Microbial pathogenesis at the proteome level * Whole cell modeling * Structural proteomics and computational analysis * Biomolecular interactions * Physiological proteomics * Metabolic reconstruction using proteomics data While presenting the practical utility of proteomics data, thetext is also clear on the field's current limitations, pointing toareas where further investigation is needed. Offering a state-of-the-art perspective from internationallyrecognized experts, this text is ideally suited for researchers andstudents across the gamut of genomic sciences, includingbiochemistry, microbiology, molecular biology, genetics, biomedicaland pharmaceutical sciences, biotechnology, and veterinaryscience.

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  • Produktdetails
  • Verlag: John Wiley & Sons
  • Seitenzahl: 530
  • Erscheinungstermin: 11. Oktober 2006
  • Englisch
  • ISBN-13: 9780471973157
  • Artikelnr.: 37347718
Autorenporträt
IAN HUMPHERY-SMITH, PHD, is the Founding Chair of the Department of Pharmaceutical Proteomics at Utrecht University. Dr. Humphery-Smith has served as director of the Centre for Proteome Research and Gene-Product Mapping and served as managing director and chief scientific officer of Glaucus Proteomics BV.MICHAEL HECKER, PHD, is Professor of Microbiology and Head of the Institute for Microbiology at Ernst-Moritz-Arndt-University of Greifswald in Germany. Dr. Hecker is currently Vice Chair of the International Union of Microbiological Societies (IUMS).
Inhaltsangabe
PART I: EDITORAL / PREFACE.

PART II: GENERAL PROTEOMICS OF MICROORGANISMS/MODEL ORGANISMS.

1. Holistic Biology of Microorganisms: Genomics, Transcriptomics and Proteomics (V. Wasinger).

2. Strategies for Measuring Dynamics: The Temporal Component of Proteomics (R. Benyon & J. Pratt).

3. The Quest for Complete Proteome Coverage (D. O'Connor, et al.).

4. The Proteome of Mycoplasma Pneumoniae (R. Herrmann & T. Ruppert).

5. Proteomics of Archaea (R. Cavicchioli, et al.).

PART III: PROTEOMICS AND CELL PHYSIOLOGY.

BASIC PHYSIOLOGY, STRESS AND STARVATION RESPONSES.

6. Elucidation of the Mechanisms of Acid Stress in Listeria Monoctogenes by Proteomic Analysis (L. Phan-Thanh & L. Jänsch).

7. Oxidation of the Bacterial Proteome in Response to Starvation (T. Nyström).

8. A Tale of Two Metal Reducers: Comparative Proteome Analysis of Geobacter Sulferreducens PCA and Shewanella Oneidensis MR-1 (C. Giometti).

9. The AMT Tag Approach to Proteomic Characterization of Deinococcus Radiodurans and Shewanella Oneidensis (M. Lipton, et al.).

PHYSIOLOGICAL PROTEOMICS OF INDUSTRIAL BACTERIA.

10. The Proteomics Corynebacterium Glutamicum-An Essential Industrial Bacterium (A. Burkovski).

11. Proteomics of Lactococcus Lactis: Phenotypes for a Domestic Bacterium (M. Kilstrup).

12. A Proteomic Survey Through the Secretome of Bacillus Subtilis (H. Antelmann).

PART IV: PROTEOMICS OF PATHOGENIC MICROORGANISMS.

BACTERIAL PATHOGENESIS.

13. Analysing Bacterial Pathogenesis at the Level of the Proteome (P. Cash).

14. Unraveling Edwardsiella Tarda Pathogenesis Using the Proteomics Approach (P. Rao, et al.).

15. Structural Proteomics and Computational Analysis of a Deadly Pathogen: Combating M. Tuberculosis from Multiple Fronts (M. Strong & C. Gouldiing).

EUKARYOTIC PATHOGENS.

16. Proteomic Studies of Plant-Pathogenic Oomycetes and Fungi (C. Bruce, et al.).

17. candida Albicans Biology and Pathogenicity: Insights from Proteomics (A. Pitarch, et al.).

18. Contributions of Proteomics to Diagnosis, Treatment and Prevention of Candidiasis (A. Pitarch, et al.).

VACCINE DEVELOPMENT.

19. Identification of Protein Candidates for Developing Bacterial Ghost Vaccines Against Brucella (A. Khan, et al.).

20. Genomics and Proteomics in Reverse Vaccines (G. Grandi).

PART V: PROTEOME DATABASES, BIOINFORMATICS AND BIOCHEMICAL MODELLING.

21. Databases and Resources for In Silico Proteome Analysis (M. Pruess, et al.).

22. Inter and Intraspecies Comparison of Microbial Proteins: Learning About Gene Ancestry Function and Species Life Style (B. Labedan & O. Lespinet).

21. Cellular Modelling of Biochemical Processes in Microorganisms (I. Goryanin, et al.).
Rezensionen
"The authors have provided a thorough overview of what is still a relatively new field of study." ( CHOICE , January 2007)