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This book describes the new imaging techniques being developed tomonitor physiological, cellular and subcellular function withinliving animals. This exciting field of imaging science bringstogether physics, chemistry, engineering, biology and medicine toyield powerful and versatile imaging approaches. By combiningadvanced non-invasive imaging technologies with new mechanisms forvisualizing biochemical events and protein and gene function,non-invasive vertebrate imaging enables the in vivo study ofbiology and offers rapid routes from basic discovery to drugdevelopment and clinical application.…mehr

Produktbeschreibung
This book describes the new imaging techniques being developed tomonitor physiological, cellular and subcellular function withinliving animals. This exciting field of imaging science bringstogether physics, chemistry, engineering, biology and medicine toyield powerful and versatile imaging approaches. By combiningadvanced non-invasive imaging technologies with new mechanisms forvisualizing biochemical events and protein and gene function,non-invasive vertebrate imaging enables the in vivo study ofbiology and offers rapid routes from basic discovery to drugdevelopment and clinical application. Combined with theavailability of an increasing number of animal models of humandisease, and the ability to perform longitudinal studies of diseaseevolution and of the long-term effects of therapeutic procedures,this new technology offers the next generation of tools forbiomedical research. Well illustrated, largely in colour, the book reviews the mostcommon and technologically advanced methods for vertebrate imaging,presented in a clear, comprehensive format. The basicprinciples are described, followed by several examples of the useof imaging in the study of living multicellular organisms,concentrating on small animal models of human diseases. Thebook illustrates: * The types of information that can be obtained with modern invivo imaging; * The substitution of imaging methods for more destructivehistological techniques; * The advantages conferred by in vivo imaging in buildinga more accurate picture of the response of tissues to stimuli overtime while significantly reducing the number of animals requiredfor such studies. Part 1 describes current techniques in in vivo imaging,providing specialists and laboratory scientists from alldisciplines with clear and helpful information regarding the toolsavailable for their specific research field. Part 2 looks inmore detail at imaging organ development and function, covering thebrain, heart, lung and others. Part 3 describes the use ofimaging to monitor various new types of therapy, following thereaction in an individual organism over time, e.g. after gene orcell therapy. Most chapters are written by teams of physicists and biologists,giving a balanced coherent description of each technique and itspotential applications.

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  • Produktdetails
  • Verlag: John Wiley & Sons
  • Seitenzahl: 388
  • Erscheinungstermin: 20. August 2007
  • Englisch
  • ISBN-13: 9780470029589
  • Artikelnr.: 37289883
Autorenporträt
Vasilis Ntziachristos. Massachusetts General Hospital, USAAnne Leroy-Willig. Université Paris-Sud, FranceBertrand Tavitian. Unité d'Imagerie de l'Expression des Genes, CEA - SHFJ - INSERM ERITM, Orsay Cedex, France
Inhaltsangabe
Contributors. Introduction. 1 Nuclear Magnetic Resonance Imaging and Spectroscopy (Anne Leroy-Willig and Danielle Geldwerth-Feniger). 2 High Resolution X-ray Microtomography: Applications in Biomedical Research (Nora De Clerck and Andrei Postnov). 3 Ultrasound Imaging (S. Lori Bridal
Jean-Michel Correas and Genevieve Berger). 4 In Vivo Radiotracer Imaging (Bertrand Tavitian
Regine Trebossen
Roberto Pasqualini and Frederic Dolle¿). 5 Optical Imaging and Tomography (Antoine Soubret and Vasilis Ntziachristos). 6 Optical Microscopy in Small Animal Research (Rakesh K. Jain
Dai Fukumura
Lance Munn and Edward Brown). 7 New Radiotracers
Reporter Probes and Contrast Agents (Coordinated by Bertrand Tavitian). 8 Multi-Modality Imaging (Coordinated by Vasilis Ntziachristos). 9 Brain Imaging (Coordinated by Anne Leroy-Willig). 10 Imaging of Heart
Muscle
Vessels (Coordinated by Yves Fromes). 11 Tumor Imaging (Coordinated by Vasilis Ntziachristos). 12 Other Organs (Coordinated by Anne Leroy-Willig). 13 Gene Therapy (Markus Klein and Andreas H. Jacobs). 14 Cellular Therapies and Cell Tracking (Coordinated by Yves Fromes). Index.