Introduction; P.L. Luisi. Historical and Philosophical Perspectives. Historical overview to the quest of self-reproduction and artificial life; S. Hoffmann. On defining life; F.J. Varela. A few precautionary words concerning terminology; G.R. Fleischaker. Template Chemistry. Molecular replication: From minimal to complex systems; D. Sievers, T. Achilles, J. Burmeister, S. Jordan, A. Terfort, G. von Kiedrowski. Self-replication and reproduction: From molecules to protocells; E. Szathmáry. Extrabiotic replication and self-assembly; J. Rebek, Jr. The prebiotic synthesis and replication of RNA oligomers: the transition from prebiotic molecules to the RNA world; J.P. Ferris. Template-directed synthesis of oligomers: Kinetics vs thermodynamic control; J.T. Goodwin, P. Luo, J.C. Leitzel, D.G. Lynn. Chirality and Replication. Chirality and the first self-replicating molecules; A.W. Schwartz, M.J. Van Vliet. Are peptides possible support for self-amplification of sequence information? A. Brack. The RNA World. Minimonsters: Evolutionary by-products of in vitro RNA amplification; R.R. Breaker, G.F. Joyce. Models for the autocatalytic replication of RNA; L. Giver, S. Lato, A. Ellington. RNA species that multiply indefinitely with RNA polymerase; C.K. Biebricher. Chemical oscillations and nonlinear chemical kinetics; P.V. Coveney. The Cell View and Cell Models. The chemical implementation of autopoiesis; P.L. Luisi. Molecular recognition in micelles; J.S. Nowick, J.S. Chen, T. Cao, G. Noronha. Self-reproducing vesicles; P. Walde. Sources and syntheses of prebiotic amphiphiles; D.W. Deamer. Ancient paralogous duplications and the search forArchean cells; V. García-Meza, A. González-Rodríguez, A. Lazcano. Posters. Self-replication of oligonucleotides in reverse micelles; C. Böhler, W. Bannwarth, P.L. Luisi. Liposomes from lipidonucleotides and from lipidopeptides; S. Bonaccio, C. Cescato, P. Walde, P.L. Luisi. Dendritic luminescent and redox-active supermolecules made of transition metal complexes; S. Campagna, G. Denti, S. Serroni, A. Juris, M. Venturi, V. Balzani. Layer-by-layer adsorption: the solid/liquid-interface as a template for the controlled growth of well defined nanostructures of polyelectrolytes, proteins, DNA and polynucleotides; G. Decher, J.-D. Hong, K. Lowack, Y. Lvov, J. Schmitt. Molecular recognition of amino acids by RNA; P. Burgstaller, D. Faulhammer, M. Famulok. Towards nature's structural guidelines: Conclusions on the unsolved structures of RNA-dependent RNA polymerases; D.L. Gerloff. A self-catalyzed (autopoietic) synthesis of an anionic surfactant: Experimental evidence and theoretical modeling; M. Fresta, M. Maestro, F. Mavelli. Competition, reciprocity, and mutation at the molecular level: Irradiation of a synthetic replicator generates a superior species; V. Rotello, Q. Feng, J.-I. Hong, J. Rebek, Jr. Giant vesicles; R. Wick, P. Walde, P.L. Luisi. Index.