PET Chemistry (eBook, PDF)
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The incessant progress in the comprehension of molecular processes of disease formation and progression is accompanied by an increasing importance of biomedical molecular imaging methods. PET, a nuclear medical imaging modality, is ideally suited to produce such kinds of images by use of positron-emitting chemical entities. The purpose of this workshop was to discuss and overview applications and technologies in the area of PET chemistry. The book provides the reader with state-of-the-art information on the different applications of PET isotopes, such as F-18, C-11, Ga-68, Cu-64, Y-86, Br-76,…mehr

Produktbeschreibung
The incessant progress in the comprehension of molecular processes of disease formation and progression is accompanied by an increasing importance of biomedical molecular imaging methods. PET, a nuclear medical imaging modality, is ideally suited to produce such kinds of images by use of positron-emitting chemical entities. The purpose of this workshop was to discuss and overview applications and technologies in the area of PET chemistry. The book provides the reader with state-of-the-art information on the different applications of PET isotopes, such as F-18, C-11, Ga-68, Cu-64, Y-86, Br-76, Br-77 and I-124, and their impact on molecular imaging. New technical features such as microwaves, microreactors and modules for the synthesis of new PET tracers are discussed. TOC:Molecular Imaging with PET - Open Questions?- Fluorine-18 Labelling Methods: Features and Possibilities of Basic Reactions.- Fluorine-18 Labelling of Small Molecules: The Use of 18F-Labelled Aryl Fluorides Derived from No-Carrier-Added [18F] Fluoride as Labelling Precursors.- F-18 Labelling of Peptides and Proteins.- [18F] Fluoropyridines: From Conventional Radiotracers to the Labelling of Macromolecules like Proteins and Oligonucleotides.- Production of Non-Standard PET Radionuclides and the Application of Radiopharmaceuticals Labelled with these Nuclides.- Carbon-11 Labelling Chemistry Based upon [11C] Methyl Iodide.- 68Ga-PET Radiopharmacy, a Generator-based Alternative to 18F-radiopharmacy.- Microwaving in F-18 Chemistry: Quirks and Tweaks.- MicroReactors for PET Tracer Labeling.- Synthesis Modules and Automationin F-18 Labelling.- Pharmacological Prerequisites for PET Ligands and Practical Issues in Preclinical PET Research.- Positron Emission Tomography (PET) Imaging as Key Enabling Technology in Drug Development.

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  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 19.01.2007
  • Englisch
  • ISBN-13: 9783540495277
  • Artikelnr.: 37368717
Inhaltsangabe
Molecular Imaging with PET - Open Questions?.- Fluorine-18 Labeling Methods: Features and Possibilities of Basic Reactions.- Fluorine-18 Labeling of Small Molecules: The Use of 18F-Labeled Aryl Fluorides Derived from No-Carrier-Added [18F]Fluoride as Labeling Precursors.- Fluorine-18 Labeling of Peptides and Proteins.- [18F]Fluoropyridines: From Conventional Radiotracers to the Labeling of Macromolecules Such as Proteins and Oligonucleotides.- Production of Non-standard PET Radionuclides and the Application of Radiopharmaceuticals Labeled with these Nuclides.- Carbon-11 Labeling Chemistry Based upon [11C]Methyl Iodide.- 68Ga-PET Radiopharmacy: A Generator-Based Alternative to 18F-Radiopharmacy.- Microwaving in F-18 Chemistry: Quirks and Tweaks.- Micro-reactors for PET Tracer Labeling.- Synthesis Modules and Automation in F-18 Labeling.- Pharmacological Prerequisites for PET Ligands and Practical Issues in Preclinical PET Research.- Positron Emission Tomography Imaging as a Key Enabling Technology in Drug Development.