Strategies for Organic Drug Synthesis and Design (eBook, PDF)
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Strategies for Organic Drug Synthesis and Design (eBook, PDF)
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This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &D, as well as medical professionals, by providing a useful guide for designing and synthesizing pharmaceutical agents.…mehr
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- Produktdetails
- Verlag: John Wiley & Sons
- Seitenzahl: 700
- Erscheinungstermin: 26. März 2009
- Englisch
- ISBN-13: 9780470399590
- Artikelnr.: 37291949
- Verlag: John Wiley & Sons
- Seitenzahl: 700
- Erscheinungstermin: 26. März 2009
- Englisch
- ISBN-13: 9780470399590
- Artikelnr.: 37291949
Prostaglandnis. 1.2 Peptidonimetic Compounds. 1.3 Retinoids. 1.4 A
Miscellaneous Drug. References. 2. DRUG BASED ON A SUBSTITUTED BENZENE RING
2.1 Arylethanolamines. 2.2 Aryloxypropanolamines. 2.3 Arylsulfonic Acid
Derivatives. 2.4 Arylacetic and Arylpropionic Acids. 3. INDENES,
NAPHTHALENES AND OTHER POLYCYCLIC AROMATIC COMPOUNDS 3.1 Indenes. 3.2
Naphthalenes. 3.3 Partly Reduced Naphthalenes. 3.4 Tricyclic Compounds.
References. 4. STEROIDS; PART 1: ESTRANES, GONANES, AND ANDROSTANES 4.1
Introduction. 4.2 Steroid Starting Materials. 4.3 Estranes. 4.4 Gonanes,
the 19-nor Steroids. 4.5 Androstanes. References. 5. STEROIDS; PART 2:
COMPOUNDS RELATED TO PROGESTERONE, CORTISONE, AND CHOLESTEROL. 5.1
Introduction. 5.2 Progestins. 5.3 Corticosteroids. 5.4 Compounds Derived
from Cholesterol. References. 6. NONSTEROIDAL SEX HORMONES AND THEIR
ANTAGONISTS 6.1 Introduction. 6.2 Estrogens. References. 7. OPIOID
ANAlGESICS 7.1 Introduction 7.2 Drugs Derived from Morphine. 7.3 Compounds
Prepared from Thebaine. 7.4 Morphinans. 7.5 Benzomorphans. 7.6 Analgesics
Based on Nonfused Piperidines. References. 8. DRUGS BASED ON FIVE-MEMBERED
HETEROCYCLES 8.1 Introduction. 8.2 Rings that Contain One Heteroatom. 8.3
Rings that Contain Two Heteroatoms. 8.4 Rings that Contains Three or More
Heteroatoms. References. 9. DRUGS BASED ON SIX-MEMBERED HETEROCYCLES. 9.1
Rings that Contain One Heteroatom. 9.2 Rings that Contain Two Heteroatoms.
9.3 Rings Containing Three Heteroatoms: The Triazines. References. 10.
FIVE-MEMBERED HETEROCYCLES FUSED TO A BENZENE RING. 10.1 Compounds that
Contain One Heteroatom. 10.2 Compounds that Contain Two Heteroatoms. 10.3
Compounds that Contain Three Heteroatoms. References. 11. SIX-MEMBERED
HETEROCYCLES FUSED TO A BENZENE RING 11.1 Compounds that Contain One
Heteroatom. 11.2 Compounds that Contain Two Heteroatoms. 11.3 Compounds
that Contain Three Heteroatoms. References. 12. SEVEN-MEMBERED HETEROCYCLIC
FUSED TO BENZENE. 12.1 Compounds with a Single Heterocyclic Atom. 12.2
Compounds with Two Heteroatoms. References. 13. HETEROCYLES FUSED TO TWO
AROMATIC RINGS 13.1 Compounds Containing a Single Heteroatom. 13.2
Compounds Containing Two Heteroatoms. 13.3 Pyridine-Based Fused Tricyclic
Compounds. References. 14. BETA LACTAM ANTIBIOTICS 14.1 Penicillins. 14.2
Cephalosporins. 14.3 Monobactams. References. 15. HETEROCYCLES FUSED TO
OTHER HETEROCYCLIC RINGS. 15.1 Two Fused Five-Membered Rings. 15.2
Five-Membered Heterocycles Fused to Six-Membered Rings. 15.3 Two Fused
Six-Membered Rings. 15.4 Heterodiazepines. 15.5 Heterocyclic Compounds with
Three or More Rings. References. Subject Index. Reaction Index. Cross Index
of Biological Activities.
Prostaglandnis. 1.2 Peptidonimetic Compounds. 1.3 Retinoids. 1.4 A
Miscellaneous Drug. References. 2. DRUG BASED ON A SUBSTITUTED BENZENE RING
2.1 Arylethanolamines. 2.2 Aryloxypropanolamines. 2.3 Arylsulfonic Acid
Derivatives. 2.4 Arylacetic and Arylpropionic Acids. 3. INDENES,
NAPHTHALENES AND OTHER POLYCYCLIC AROMATIC COMPOUNDS 3.1 Indenes. 3.2
Naphthalenes. 3.3 Partly Reduced Naphthalenes. 3.4 Tricyclic Compounds.
References. 4. STEROIDS; PART 1: ESTRANES, GONANES, AND ANDROSTANES 4.1
Introduction. 4.2 Steroid Starting Materials. 4.3 Estranes. 4.4 Gonanes,
the 19-nor Steroids. 4.5 Androstanes. References. 5. STEROIDS; PART 2:
COMPOUNDS RELATED TO PROGESTERONE, CORTISONE, AND CHOLESTEROL. 5.1
Introduction. 5.2 Progestins. 5.3 Corticosteroids. 5.4 Compounds Derived
from Cholesterol. References. 6. NONSTEROIDAL SEX HORMONES AND THEIR
ANTAGONISTS 6.1 Introduction. 6.2 Estrogens. References. 7. OPIOID
ANAlGESICS 7.1 Introduction 7.2 Drugs Derived from Morphine. 7.3 Compounds
Prepared from Thebaine. 7.4 Morphinans. 7.5 Benzomorphans. 7.6 Analgesics
Based on Nonfused Piperidines. References. 8. DRUGS BASED ON FIVE-MEMBERED
HETEROCYCLES 8.1 Introduction. 8.2 Rings that Contain One Heteroatom. 8.3
Rings that Contain Two Heteroatoms. 8.4 Rings that Contains Three or More
Heteroatoms. References. 9. DRUGS BASED ON SIX-MEMBERED HETEROCYCLES. 9.1
Rings that Contain One Heteroatom. 9.2 Rings that Contain Two Heteroatoms.
9.3 Rings Containing Three Heteroatoms: The Triazines. References. 10.
FIVE-MEMBERED HETEROCYCLES FUSED TO A BENZENE RING. 10.1 Compounds that
Contain One Heteroatom. 10.2 Compounds that Contain Two Heteroatoms. 10.3
Compounds that Contain Three Heteroatoms. References. 11. SIX-MEMBERED
HETEROCYCLES FUSED TO A BENZENE RING 11.1 Compounds that Contain One
Heteroatom. 11.2 Compounds that Contain Two Heteroatoms. 11.3 Compounds
that Contain Three Heteroatoms. References. 12. SEVEN-MEMBERED HETEROCYCLIC
FUSED TO BENZENE. 12.1 Compounds with a Single Heterocyclic Atom. 12.2
Compounds with Two Heteroatoms. References. 13. HETEROCYLES FUSED TO TWO
AROMATIC RINGS 13.1 Compounds Containing a Single Heteroatom. 13.2
Compounds Containing Two Heteroatoms. 13.3 Pyridine-Based Fused Tricyclic
Compounds. References. 14. BETA LACTAM ANTIBIOTICS 14.1 Penicillins. 14.2
Cephalosporins. 14.3 Monobactams. References. 15. HETEROCYCLES FUSED TO
OTHER HETEROCYCLIC RINGS. 15.1 Two Fused Five-Membered Rings. 15.2
Five-Membered Heterocycles Fused to Six-Membered Rings. 15.3 Two Fused
Six-Membered Rings. 15.4 Heterodiazepines. 15.5 Heterocyclic Compounds with
Three or More Rings. References. Subject Index. Reaction Index. Cross Index
of Biological Activities.