Drug Discovery in Pancreatic Cancer (eBook, PDF)

Models and Techniques
Redaktion: Han, Haiyong; Grippo, Paul

• Format: PDF

Produktbeschreibung

Over the past two decades, tremendous advances have been made in the field of cancer drug discovery, particularly in the area of molecular and genetic models and technologies, many of which have been or are beginning to be applied to the drug discovery process for pancreatic cancer. Drug Discovery in Pancreatic Cancer: Models and Techniques offers the latest development in the application of those models and technologies in pancreatic cancer. The authors include experts in their perspective field of research including basic scientists as well as clinicians who work on the frontline in the war against pancreatic cancer and have first-hand experience employing these cutting-edge tools and techniques. The book progresses logically from modeling systems to genomic profiling, proteomic analysis, and pharmacodynamic assays. It features: .Up-to-date survey of many cell lines and animal models of pancreatic cancer and their applications in drug discovery. .Application of fluorescent mouse models in pancreatic cancer drug discovery. .Utility of cutting-edge genomics, proteomics, epigenomics, and glycomics methodologies for molecular target identification and validation. .Discussion of microRNA profiling and high throughput RNAi screening for pancreatic cancer drug discovery. .Broad screening technologies for proteins and nucleic acids using tissue microarrays and CGH arrays. .Development of pharmacodynamic endpoint assays for targeted therapeutics. Comprehensive and practical Drug Discovery in Pancreatic Cancer: Models and Techniques offers both basic and clinical scientists who are interested in pancreatic cancer an up-to-date review and assessment of models and technologies being applied in drug discovery for pancreatic cancer. The true premise of this book is to provide a guide for drug discovery and evaluation, with consideration of various modeling systems and the methods for screening/profiling responses to these compounds. It is the Editors intent to stimulate new thought in this area of research as a means of generating much improved drug efficacy for greater survival and quality of life for patients battling pancreatic cancer.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: Springer-Verlag GmbH
• Seitenzahl: 297
• Erscheinungstermin: 11. März 2010
• Englisch
• ISBN-13: 9781441911605
• Artikelnr.: 37340250

Inhaltsangabe

Chapter 1: Pancreatic cancer cell line modelsSteven Warner, Ph.D.Translational Genomics Research InstituteDivision of Clinical Translational ResearchChapter 2: Pancreatic cancer xenograft modelsManuel Hidalgo, M.D., Ph.D.Johns Hopkins University School of MedicineChapter 3: Pancreatic cancer transgenic mouse modelsDavid A. Tuveson M.D., Ph.D.Cancer Research UK Cambridge Research InstituteChapter 4: Pancreatic cancer zebra fish modelsSteven Leach, M.D.Division of Surgical OncologyJohns Hopkins University School of MedicineChapter 5: DNA microarray expression profilingCharles Gawad, M.D.School of MedicineUniversity of California at Los AngelesChapter 6: Array CGH profilingRobert Lucito, Ph.D.Cold Spring Harbor LaboratoryChapter 7: High throughput siRNASpyro Mousses, Ph.D.Division of Pharmaceutical GenomicsTranslational Genomics Research InstituteChapter 8: miRNA profilingGlen J. Weiss, M.DUniversity of Colorado Health Science CenterDepartment of Hematology and Medical OncologyChapter 9: Methylation detection and epigeneticsBernard W. Futscher, Ph.D.Arizona Cancer CenterChapter 10: Tissue microarray based IHC and FISHAnirban Maitra, MBBSThe Sol Goldman Pancreatic Cancer Research CenterJohns Hopkins University School of MedicineChapter 11: Spectral Karyotyping (SKY) and M-FISHThomas R. Dennis, Ph.D.Translational Genomics Research InstituteChapter 12: Proteomics analysis of serum and pancreatic juiceMichael Goggins, M.D.The Sol Goldman Pancreatic Cancer Research CenterThe Johns Hopkins University School of MedicineChapter 13: Glycomics analysis of serum and pancreatic juice samplesJ. Michael Pierce, Ph.D.University of GeorgiaDirector, UGA Cancer CenterChapter 14: Protein arrays for pancreatic cancer researchRaoul Tibes, M.D.Division of Pharmaceutical GenomicsTranslational Genomics Research InstituteChapter 15: Vaccines for pancreatic cancerDan A. Laheru, M.D.Buntings Blaustein Cancer Research Building Room G89Chapter 16: Molecular imaging of small animalsRobert J. Gillies, Ph.D.Department of RadiologyArizona Cancer Center, MRB 138Chapter 17 : Development of pharmacodynamic endpoint models for the evaluation of clinical activities of targeted therapeuticsAmanda Baker, Ph.D.Arizona Cancer Center