Biomarkers (eBook, PDF)
In Medicine, Drug Discovery, and Environmental Health
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Biomarkers (eBook, PDF)
In Medicine, Drug Discovery, and Environmental Health
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This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson's, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process.
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This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson's, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process.
Produktdetails
- Produktdetails
- Verlag: John Wiley & Sons
- Seitenzahl: 632
- Erscheinungstermin: 4. November 2010
- Englisch
- ISBN-13: 9780470918555
- Artikelnr.: 37300580
- Verlag: John Wiley & Sons
- Seitenzahl: 632
- Erscheinungstermin: 4. November 2010
- Englisch
- ISBN-13: 9780470918555
- Artikelnr.: 37300580
VISHAL S. VAIDYA, PHD, is an Assistant Professor of Medicine at Harvard Medical School in the Renal Division of Brigham and Women's Hospital. He directs the Laboratory of Kidney Toxicology and Regeneration with a research emphasis on discovery and evaluation of biomarkers and biosensors for early detection of kidney injury and investigates the molecular mechanisms of kidney tissue repair. Dr. Vaidya has authored more than thirty-five original research articles and twelve chapters and reviews. He serves as a councilor for the northeast chapter of the Society of Toxicology and is an elected member of Harvard School of Public Health's Center for Environmental Health. He is the recipient of the Pathway to Independence grant by the National Institute of Environmental Health Sciences. JOSEPH V. BONVENTRE, MD, PHD, is the Samuel A. Levine Professor of Medicine at Harvard Medical School. He is also Chief of the Renal Division and Director of the Biomedical Engineering Division of Brigham and Women's Hospital and is President-elect of the American Society of Nephrology. He has authored more than 250 original papers and 120 chapters and reviews. His research focuses primarily on the study of kidney injury and repair and signal transduction, with special emphasis on the role of inflammation, biomarkers, and stem cells. Bonventre has received a MERIT award from the National Institute of Diabetes and Digestive and Kidney Diseases.
Preface xxii Contributors xxv 1 Biomarkers: An Evolutionary Perspective 1 Michael Ferguson and Vishal Vaidya Section I: Tools for Biomarker Discovery 5 2 Genomics 7 Weida Tong and Donna L. Mendrick 3 Proteomics for Biomarker Discovery 25 Timothy D. Veenstra 4 Metabolic Profiling for Biomarker Discovery 47 Hector C. Keun 5 The Bittersweet Promise of Glycobiology 75 Padmaparna Chaudhuri, Rania Harfouche, and Shiladitya Sengupta Section II: Biomarkers of Injury/Disease 89 6 Biomarkers of Alzheimer's and Parkinson's Disease 91 Walter Maetzler and Daniela Berg 7 Biomarkers of Cardiac Injury 119 Anthony S. McLean and Stephen J. Huang 8 Lung Injury Biomarkers 157 Urmila P. Kodavanti 9 Translational Biomarkers of Acute Drug-Induced Liver Injury: The Current State, Gaps and Future Opportunities 203 Josef Ozer, William Reagan, Sheli Schomaker, Joe Palandra, Mike Baratta and Shashi Ramaiah 10 Biomarkers of Acute Kidney Injury 237 Frank Dieterle and Frank Sistare 11 In Search of Biomarkers for Drug-Induced Vascular Injury 281 James R. Turk 12 Biomarkers of Immunotoxicity 307 Rodney R. Dietert 13 Biomarkers in Obstetric Medicine 323 Manish Maski, Sarosh Rana and S. Ananth Karumanchi 14 Biomarkers in Cancer 355 Roopali Roy, Christine M. Coticchia, Jiang Yang and Marsha A. Moses 15 Biomarkers of HIV 381 Lewis Kaufman and Michael J Ross 16 Biomarkers of in Vitro Drug-Induced Mitochondrial Dysfunction 401 James A. Dykens and Yvonne Will Section III: Technology for Biomarker Detection 423 17 Immunoassay-Based Technologies for the Measurement of Biological Materials Used for Biomarkers Discovery and Translational Research 425 Vincent Ricchiuti 18 Nanoscale Techniques for Biomarker Quantification 457 Madhukar Varshney, and Harold G. Craighead 19 Immunodiagnostics with a Focus on Lateral Flow Point-of-Care Devices 495 Roy R. Mondesire, Glen M. Ford, Hannie F. Ford, and Stephen C. Mefferd Section IV: Hot Topics In Biomarker Research 517 20 Biomarkers for Environmental Exposure 519 Jane E. Gallagher, Elaine A. Cohen Hubal and Stephen W. Edwards 21 Clinical Study Design in Biomarker Research 549 Orfeas Liangos and Bertrand L. Jaber 22 Statistical Issues in Biomarker Research 561 Daniel Holder and Matthew Schipper 23 Regulatory Perspective for Biomarker Qualification from U.S. FDA 581 Federico Goodsaid 24 The European Medicines Agency Approach 589 Marisa Papaluca Amati and Spiros Vamvakas Index 595
Preface. Contributors. 1 Biomarkers: An Evolutionary Perspective (Michael
Ferguson and Vishal Vaidya). SECTION I: TOOLS FOR BIOMARKER DISCOVERY. 2
Genomics (Weida Tong and Donna L. Mendrick). 3 Proteomics for Biomarker
Discovery (Timothy D. Veenstra). 4 Metabolic Profiling for Biomarker
Discovery (Hector C. Keun). 5 The Bittersweet Promise of Glycobiology
(Padmaparna Chaudhuri, Rania Harfouche, and Shiladitya Sengupta). SECTION
II: BIOMARKERS OF INJURY/DISEASE. 6 Biomarkers of Alzheimer's and
Parkinson's Disease (Walter Maetzler and Daniela Berg). 7 Biomarkers of
Cardiac Injury (Anthony S. McLean and Stephen J. Huang). 8 Lung Injury
Biomarkers (Urmila P. Kodavanti). 9 Translational Biomarkers of Acute
Drug-Induced Liver Injury: The Current State, Gaps and Future Opportunities
(Josef Ozer, William Reagan, Sheli Schomaker, Joe Palandra, Mike Baratta
and Shashi Ramaiah). 10 Biomarkers of Acute Kidney Injury (Frank Dieterle
and Frank Sistare). 11 In Search of Biomarkers for Drug-Induced Vascular
Injury (James R. Turk). 12 Biomarkers of Immunotoxicity (Rodney R.
Dietert). 13 Biomarkers in Obstetric Medicine (Manish Maski, Sarosh Rana
and S. Ananth Karumanchi. 14 Biomarkers in Cancer (Roopali Roy, Christine
M. Coticchia, Jiang Yang and Marsha A. Moses). 15 Biomarkers of HIV (Lewis
Kaufman and Michael J Ross). 16 Biomarkers of In Vitro Drug-Induced
Mitochondrial Dysfunction (James A. Dykens and Yvonne Will). SECTION III:
TECHNOLOGY FOR BIOMARKER DETECTION. 17 Immunoassay-Based Technologies for
the Measurement of Biological Materials Used for Biomarkers Discovery and
Translational Research (Vincent Ricchiuti). 18 Nanoscale Techniques for
Biomarker Quantification (Madhukar Varshney, and Harold G. Craighead). 19
Immunodiagnostics with a Focus on Lateral Flow Point-of-Care Devices (Roy
R. Mondesire, Glen M. Ford, Hannie F. Ford, and Stephen C. Mefferd).
SECTION IV: HOT TOPICS IN BIOMARKER RESEARCH. 20 Biomarkers for
Environmental Exposure (Jane E. Gallagher, Elaine A. Cohen Hubal and
Stephen W. Edwards). 21 Clinical Study Design in Biomarker Research (Orfeas
Liangos and Bertrand L. Jaber). 22 Statistical Issues in Biomarker Research
(Daniel Holder and Matthew Schipper). 23 Regulatory Perspective for
Biomarker Qualification from U.S. FDA (Federico Goodsaid). 24 The European
Medicines Agency Approach (Marisa Papaluca Amati and Spiros Vamvakas).
Index.
Ferguson and Vishal Vaidya). SECTION I: TOOLS FOR BIOMARKER DISCOVERY. 2
Genomics (Weida Tong and Donna L. Mendrick). 3 Proteomics for Biomarker
Discovery (Timothy D. Veenstra). 4 Metabolic Profiling for Biomarker
Discovery (Hector C. Keun). 5 The Bittersweet Promise of Glycobiology
(Padmaparna Chaudhuri, Rania Harfouche, and Shiladitya Sengupta). SECTION
II: BIOMARKERS OF INJURY/DISEASE. 6 Biomarkers of Alzheimer's and
Parkinson's Disease (Walter Maetzler and Daniela Berg). 7 Biomarkers of
Cardiac Injury (Anthony S. McLean and Stephen J. Huang). 8 Lung Injury
Biomarkers (Urmila P. Kodavanti). 9 Translational Biomarkers of Acute
Drug-Induced Liver Injury: The Current State, Gaps and Future Opportunities
(Josef Ozer, William Reagan, Sheli Schomaker, Joe Palandra, Mike Baratta
and Shashi Ramaiah). 10 Biomarkers of Acute Kidney Injury (Frank Dieterle
and Frank Sistare). 11 In Search of Biomarkers for Drug-Induced Vascular
Injury (James R. Turk). 12 Biomarkers of Immunotoxicity (Rodney R.
Dietert). 13 Biomarkers in Obstetric Medicine (Manish Maski, Sarosh Rana
and S. Ananth Karumanchi. 14 Biomarkers in Cancer (Roopali Roy, Christine
M. Coticchia, Jiang Yang and Marsha A. Moses). 15 Biomarkers of HIV (Lewis
Kaufman and Michael J Ross). 16 Biomarkers of In Vitro Drug-Induced
Mitochondrial Dysfunction (James A. Dykens and Yvonne Will). SECTION III:
TECHNOLOGY FOR BIOMARKER DETECTION. 17 Immunoassay-Based Technologies for
the Measurement of Biological Materials Used for Biomarkers Discovery and
Translational Research (Vincent Ricchiuti). 18 Nanoscale Techniques for
Biomarker Quantification (Madhukar Varshney, and Harold G. Craighead). 19
Immunodiagnostics with a Focus on Lateral Flow Point-of-Care Devices (Roy
R. Mondesire, Glen M. Ford, Hannie F. Ford, and Stephen C. Mefferd).
SECTION IV: HOT TOPICS IN BIOMARKER RESEARCH. 20 Biomarkers for
Environmental Exposure (Jane E. Gallagher, Elaine A. Cohen Hubal and
Stephen W. Edwards). 21 Clinical Study Design in Biomarker Research (Orfeas
Liangos and Bertrand L. Jaber). 22 Statistical Issues in Biomarker Research
(Daniel Holder and Matthew Schipper). 23 Regulatory Perspective for
Biomarker Qualification from U.S. FDA (Federico Goodsaid). 24 The European
Medicines Agency Approach (Marisa Papaluca Amati and Spiros Vamvakas).
Index.
Preface xxii Contributors xxv 1 Biomarkers: An Evolutionary Perspective 1 Michael Ferguson and Vishal Vaidya Section I: Tools for Biomarker Discovery 5 2 Genomics 7 Weida Tong and Donna L. Mendrick 3 Proteomics for Biomarker Discovery 25 Timothy D. Veenstra 4 Metabolic Profiling for Biomarker Discovery 47 Hector C. Keun 5 The Bittersweet Promise of Glycobiology 75 Padmaparna Chaudhuri, Rania Harfouche, and Shiladitya Sengupta Section II: Biomarkers of Injury/Disease 89 6 Biomarkers of Alzheimer's and Parkinson's Disease 91 Walter Maetzler and Daniela Berg 7 Biomarkers of Cardiac Injury 119 Anthony S. McLean and Stephen J. Huang 8 Lung Injury Biomarkers 157 Urmila P. Kodavanti 9 Translational Biomarkers of Acute Drug-Induced Liver Injury: The Current State, Gaps and Future Opportunities 203 Josef Ozer, William Reagan, Sheli Schomaker, Joe Palandra, Mike Baratta and Shashi Ramaiah 10 Biomarkers of Acute Kidney Injury 237 Frank Dieterle and Frank Sistare 11 In Search of Biomarkers for Drug-Induced Vascular Injury 281 James R. Turk 12 Biomarkers of Immunotoxicity 307 Rodney R. Dietert 13 Biomarkers in Obstetric Medicine 323 Manish Maski, Sarosh Rana and S. Ananth Karumanchi 14 Biomarkers in Cancer 355 Roopali Roy, Christine M. Coticchia, Jiang Yang and Marsha A. Moses 15 Biomarkers of HIV 381 Lewis Kaufman and Michael J Ross 16 Biomarkers of in Vitro Drug-Induced Mitochondrial Dysfunction 401 James A. Dykens and Yvonne Will Section III: Technology for Biomarker Detection 423 17 Immunoassay-Based Technologies for the Measurement of Biological Materials Used for Biomarkers Discovery and Translational Research 425 Vincent Ricchiuti 18 Nanoscale Techniques for Biomarker Quantification 457 Madhukar Varshney, and Harold G. Craighead 19 Immunodiagnostics with a Focus on Lateral Flow Point-of-Care Devices 495 Roy R. Mondesire, Glen M. Ford, Hannie F. Ford, and Stephen C. Mefferd Section IV: Hot Topics In Biomarker Research 517 20 Biomarkers for Environmental Exposure 519 Jane E. Gallagher, Elaine A. Cohen Hubal and Stephen W. Edwards 21 Clinical Study Design in Biomarker Research 549 Orfeas Liangos and Bertrand L. Jaber 22 Statistical Issues in Biomarker Research 561 Daniel Holder and Matthew Schipper 23 Regulatory Perspective for Biomarker Qualification from U.S. FDA 581 Federico Goodsaid 24 The European Medicines Agency Approach 589 Marisa Papaluca Amati and Spiros Vamvakas Index 595
Preface. Contributors. 1 Biomarkers: An Evolutionary Perspective (Michael
Ferguson and Vishal Vaidya). SECTION I: TOOLS FOR BIOMARKER DISCOVERY. 2
Genomics (Weida Tong and Donna L. Mendrick). 3 Proteomics for Biomarker
Discovery (Timothy D. Veenstra). 4 Metabolic Profiling for Biomarker
Discovery (Hector C. Keun). 5 The Bittersweet Promise of Glycobiology
(Padmaparna Chaudhuri, Rania Harfouche, and Shiladitya Sengupta). SECTION
II: BIOMARKERS OF INJURY/DISEASE. 6 Biomarkers of Alzheimer's and
Parkinson's Disease (Walter Maetzler and Daniela Berg). 7 Biomarkers of
Cardiac Injury (Anthony S. McLean and Stephen J. Huang). 8 Lung Injury
Biomarkers (Urmila P. Kodavanti). 9 Translational Biomarkers of Acute
Drug-Induced Liver Injury: The Current State, Gaps and Future Opportunities
(Josef Ozer, William Reagan, Sheli Schomaker, Joe Palandra, Mike Baratta
and Shashi Ramaiah). 10 Biomarkers of Acute Kidney Injury (Frank Dieterle
and Frank Sistare). 11 In Search of Biomarkers for Drug-Induced Vascular
Injury (James R. Turk). 12 Biomarkers of Immunotoxicity (Rodney R.
Dietert). 13 Biomarkers in Obstetric Medicine (Manish Maski, Sarosh Rana
and S. Ananth Karumanchi. 14 Biomarkers in Cancer (Roopali Roy, Christine
M. Coticchia, Jiang Yang and Marsha A. Moses). 15 Biomarkers of HIV (Lewis
Kaufman and Michael J Ross). 16 Biomarkers of In Vitro Drug-Induced
Mitochondrial Dysfunction (James A. Dykens and Yvonne Will). SECTION III:
TECHNOLOGY FOR BIOMARKER DETECTION. 17 Immunoassay-Based Technologies for
the Measurement of Biological Materials Used for Biomarkers Discovery and
Translational Research (Vincent Ricchiuti). 18 Nanoscale Techniques for
Biomarker Quantification (Madhukar Varshney, and Harold G. Craighead). 19
Immunodiagnostics with a Focus on Lateral Flow Point-of-Care Devices (Roy
R. Mondesire, Glen M. Ford, Hannie F. Ford, and Stephen C. Mefferd).
SECTION IV: HOT TOPICS IN BIOMARKER RESEARCH. 20 Biomarkers for
Environmental Exposure (Jane E. Gallagher, Elaine A. Cohen Hubal and
Stephen W. Edwards). 21 Clinical Study Design in Biomarker Research (Orfeas
Liangos and Bertrand L. Jaber). 22 Statistical Issues in Biomarker Research
(Daniel Holder and Matthew Schipper). 23 Regulatory Perspective for
Biomarker Qualification from U.S. FDA (Federico Goodsaid). 24 The European
Medicines Agency Approach (Marisa Papaluca Amati and Spiros Vamvakas).
Index.
Ferguson and Vishal Vaidya). SECTION I: TOOLS FOR BIOMARKER DISCOVERY. 2
Genomics (Weida Tong and Donna L. Mendrick). 3 Proteomics for Biomarker
Discovery (Timothy D. Veenstra). 4 Metabolic Profiling for Biomarker
Discovery (Hector C. Keun). 5 The Bittersweet Promise of Glycobiology
(Padmaparna Chaudhuri, Rania Harfouche, and Shiladitya Sengupta). SECTION
II: BIOMARKERS OF INJURY/DISEASE. 6 Biomarkers of Alzheimer's and
Parkinson's Disease (Walter Maetzler and Daniela Berg). 7 Biomarkers of
Cardiac Injury (Anthony S. McLean and Stephen J. Huang). 8 Lung Injury
Biomarkers (Urmila P. Kodavanti). 9 Translational Biomarkers of Acute
Drug-Induced Liver Injury: The Current State, Gaps and Future Opportunities
(Josef Ozer, William Reagan, Sheli Schomaker, Joe Palandra, Mike Baratta
and Shashi Ramaiah). 10 Biomarkers of Acute Kidney Injury (Frank Dieterle
and Frank Sistare). 11 In Search of Biomarkers for Drug-Induced Vascular
Injury (James R. Turk). 12 Biomarkers of Immunotoxicity (Rodney R.
Dietert). 13 Biomarkers in Obstetric Medicine (Manish Maski, Sarosh Rana
and S. Ananth Karumanchi. 14 Biomarkers in Cancer (Roopali Roy, Christine
M. Coticchia, Jiang Yang and Marsha A. Moses). 15 Biomarkers of HIV (Lewis
Kaufman and Michael J Ross). 16 Biomarkers of In Vitro Drug-Induced
Mitochondrial Dysfunction (James A. Dykens and Yvonne Will). SECTION III:
TECHNOLOGY FOR BIOMARKER DETECTION. 17 Immunoassay-Based Technologies for
the Measurement of Biological Materials Used for Biomarkers Discovery and
Translational Research (Vincent Ricchiuti). 18 Nanoscale Techniques for
Biomarker Quantification (Madhukar Varshney, and Harold G. Craighead). 19
Immunodiagnostics with a Focus on Lateral Flow Point-of-Care Devices (Roy
R. Mondesire, Glen M. Ford, Hannie F. Ford, and Stephen C. Mefferd).
SECTION IV: HOT TOPICS IN BIOMARKER RESEARCH. 20 Biomarkers for
Environmental Exposure (Jane E. Gallagher, Elaine A. Cohen Hubal and
Stephen W. Edwards). 21 Clinical Study Design in Biomarker Research (Orfeas
Liangos and Bertrand L. Jaber). 22 Statistical Issues in Biomarker Research
(Daniel Holder and Matthew Schipper). 23 Regulatory Perspective for
Biomarker Qualification from U.S. FDA (Federico Goodsaid). 24 The European
Medicines Agency Approach (Marisa Papaluca Amati and Spiros Vamvakas).
Index.