Adrenocortical Carcinoma (eBook, PDF)

Basic Science and Clinical Concepts
Redaktion: Hammer, Gary D.; Else, Tobias

• Format: PDF

Produktbeschreibung

This first edition of the textbook "Adrenocortical Carcinoma: Basic Sciences and Clinical Concepts" provides a concise compilation of relevant data advancing our current understanding of this rare cancer. Chapters are dedicated to various aspects of both the basic biology and the clinical science relating to adrenocortical carcinoma (ACC). Expert clinicians introduce the reader to current state-of-the-art clinical care of patients with ACC. As a considerable body of knowledge on ACC has accumulated over the last decades, expert scientists have authored additional sections that serve as a reference source for the experienced researcher as well as an introduction for the trainee in the laboratory or clinic. Clinical topics span the epidemiology, diagnosis and therapy of ACC. Scientific topics areas span the pathology and pathophysiology of ACC with a special focus on experimental models of adrenocortical tumors and recent advances in the genetic aspects and signaling pathways in ACC. The content of this book was compiled and edited with the intent of facilitating the translation of knowledge into future diagnostic and therapeutic tools that will ultimately improve patient care.

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Produktdetails

• Verlag: Springer-Verlag GmbH
• Seitenzahl: 546
• Erscheinungstermin: 23. November 2010
• Englisch
• ISBN-13: 9780387772363
• Artikelnr.: 37286836

Inhaltsangabe

Preface1. History of ACC Research and Clinical Care1.1. ACC - A 50 year retrospective view1.2. History of ACC Treatment - A Surgical Perspective2. Epidemiology, Presentation and Diagnosis2.1. Epidemiology2.2. Presentation and Diagnosis2.3. Approach to the Adrenal incidentaloma3.0. Imaging3.1. Anatomic imaging3.2. Functional imaging4. Pathology4.1. ACC Histopathology4.2. Molecular and Cellular Pathology5. Genetic & Molecular Aspects of ACC5.1. Overview of the Genetics of ACC5.2. Li Fraumeni Syndrome5.3. P53 Molecular Genetics5.4. Telomeres and ACC5.5. Beckwith Wiedemann Syndrome5.6. Insulin-like growth Factors5.7. Wnt signaling6. Models of Adrenocortical Cancer6.1. Cellular origin and identity of ACC6.2. Adrenocortical cell lines6.3. Mouse Models of Adrenal Tumorigenesis7. Therapies7.1. Introduction7.2. Mitotane7.3. Cytotoxic Chemotherapy7.4. Steroidogenesis and Therapy of Hormone Excess7.5. Surgical therapy7.6. Radiation Therapy7.7. Surveillance and follow up of ACC8 Unique ACC Cohorts and Future Perspectives8.1.. Aldosterone producing ACC8.2. Childhood ACC8.3. Molecular Profiling of Adrenal Cancer8.4. Clinical Registries: Dutch and European experiences8.5. Emerging Strategies