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Apoptosis, Senescence and Cancer provides insight into established practices and research into apoptosis and senescence by thoroughly examining novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers. The volume is divided into six easy to follow sections. The first is Apoptosis and Alternative Modes of Cell Death, followed by chapters on Telomeres and Telomerase, Senescence, Genomic Instability and Tumorigenesis. The third part covers DNA…mehr

Produktbeschreibung
Apoptosis, Senescence and Cancer provides insight into established practices and research into apoptosis and senescence by thoroughly examining novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers. The volume is divided into six easy to follow sections. The first is Apoptosis and Alternative Modes of Cell Death, followed by chapters on Telomeres and Telomerase, Senescence, Genomic Instability and Tumorigenesis. The third part covers DNA Damage Response, Signaling Pathways and Tumorigenesis, while the fourth delves into Resistance and Sensitization. The book concludes with Established Cancer Therapies and a section which looks toward the future with Recent and Developing Cancer Therapies. In total, this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment, both in the initial stages of the disease as well as in disease recurrence. TOC:The Intrinsic Pathway of Apoptosis.- The Intrinsic Pathway of Apoptosis.- The Intrinsic Pathway of Apoptosis.- Mitotic Catastrophe.- Autophagy and Autophagic Cell Death.- Regulation and Function of Detachment-Induced Cell Death (Anoikis) in Cancer Progression and Metastasis.- Structure and Function of the Telomere.- Overview of Senescence.- Contributions of Telomerase to Tumorigenesis.- The Role of Telomeres in Genomic Instability.- Overview of the DNA Damage Checkpoint - ATM and ATR.- Interactions Between Myc and Cyclin Dependent Kinase Inhibitors in Cancer.- Interplay between H2AX And 53BP1 Pathways in DNA Double Strand Break Repair Response.- DNA-Dependent Protein Kinase in Repair, Apoptosis, Telomere Maintenance and Chemotherapy.- Resistance/Signaling Pathways.- Ceramide and Multi-Drug Resistance.- Chemo and Radio-Sensitization Through Inhibition Of PI3/Akt Signaling.- The Advancement of Epidermal Growth Factor Receptor Inhibitors in Cancer Therapy.- Antimetabolites.- Topoiseomerase I Poisons and Apoptotic Topoisomerase I-DNA Complexes.- Perturbations of Cellular Functions by Topoisomerase II Inhibitors: All Roads Lead to Cell Death?- The Significance of Poly-Targeting in Apoptosis Induction by Alkylating Agents and Platinum Drugs.- Contributions of Apoptosis and Senescence to Cytotoxicity Produced by Microtubule Stabilizing Agents.- Tyrosine Kinase Inhibitors.- Humanized Antibodies.- Role of Apoptosis in Anti-Angiogenic Cancer Therapies.- Photodynamic Therapy-Induced Apoptosis.- Modulation of TRAIL Signaling for Cancer Therapy.

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  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 23. Oktober 2007
  • Englisch
  • ISBN-13: 9781597452212
  • Artikelnr.: 37348124
Autorenporträt
David A. Gewirtz, Virginia Commonwealth University, Richmond, VA, USA / Steven Grant, Virginia Commonwealth University, Richmond, VA, USA / Shawn E. Holt, Virginia Commonwealth University, Richmond, VA, USA
Inhaltsangabe
Apoptosis, Senescence and Cancer
Section I: Apoptosis and Alternative Models of Cell Death
Chapter 1. The intrinsic pathway of apoptosis. Scott H. Kaufman
Chapter 2. The extrinsic pathway of apoptosis. M. Stacey Ricci and Wafik S. El-Deiry
Chapter 3. Evaluating the importance of apoptosis and other determinants of cell death and survival. Bradley G. Wouters and Roland K. Chiu
Chapter 4. Mitotic catastrophe. Fiorenza Ianzini and Michael A. Mackey
Chapter 5. Autophagy and autophagic cell death. Mojgan Djavaheri-Mergny, Joelle Botti and Patrice Codogno
Chapter 6. Regulation and function of detachment-induced cell death (anoikis) in cancer progression and metastasis. David J. McConkey and Victor Bondar
Section II. Telomeres and Telomerase, Senescence, Genomic Instability and Tumorigenesis
Chapter 7. Structure and function of the telomere. Jay E. Johnson and Dominique Broccoli
Chapter 8. Overview of Senescence. Ruben D. Ramirez
Chapter 9. Contributions of telomerase to tumorigenesis. Richard Possemato and William C. Hahn
Chapter 10. The role of telomeres in genomic instability. John P. Murnane
Section III. DNA Damage Response, Signaling Pathways and Tumorigenesis
Chapter 11. Overview of the DNA damage checkpoint -- ATM and ATR. Aude Dupre and Jean Gautier
Chapter 12. Interactions between myc and cyclin dependent kinase inhibitors in cancer. Kirsteen H. Maclean and John L. Cleveland
Chapter 13. Interplay between H2AX and 53BP1 pathways in DNA double strand break repair response. Fatouros Chronis and Emmy P. Rogakou
Chapter 14. DNA-dependent protein kinase in repair, apoptosis, telomere maintenance and chemotherapy. Lawrence F. Povirk
Section IV. Resistance and Sensitization
Chapter 15. Resistance/signaling pathways. Paul Dent
Chapter 16. Ceramide and multi-drug resistance. Myles C. Cabot
Chapter 17. Chemo and radio-sensitization through inhibition of PI3/Akt signaling. Debra L. Smith, Laura K. Nolden, Gordon B. Mills and Yiling Lu
Chapter 18. The advancement of epidermal growth factor receptor inhibitors in cancer therapy. Gregory W. Allen and Paul M. Harari
Section V. Established Cancer Therapies
Chapter 19. Antimetabolites. Janet A. Houghton
Chapter 20. Topoiseomerase I poisons and apoptotic topoisomerase I-DNA complexes. Olivier Sordet, Yves Pommier and Eric Solary
Chapter 21. Perturbations of cellular functions by topoisomerase II inhibitors: all roads lead to cell death? Annette K. Larsen and Andrzej Skladanowski
Chapter 22. The significance of poly-targeting in apoptosis induction by alkylating agents and platinum drugs. Jan M. Woynarowski and Barbara A. Woynarowska
Chapter 23. Contributions of apoptosis and senescence to cytotoxicity produced by microtubule stabilizing agents. Laura E. Klein and Susan B. Horwitz
Section VI. Recent and Developing Cancer Therapies
Chapter 24. Tyrosine kinase inhibitors. Michael Deininger
Chapter 25. Humanized antibodies. Morton Coleman and Richard Furman
Chapter 26. Role of apoptosis in anti-angiogenic cancer therapies. Jennifer A. Doll, Jennifer E. Hobbs and Gerald A. Soff
Chapter 27. Photodynamic therapy-induced apoptosis. Nancy L. Oleinick, Rachel L. Morris and Anna Lisa Nieminen
Chapter 28. Modulation of TRAIL signaling for cancer therapy. Simone Fulda and Klaus-Michael Debatin
Rezensionen
From the reviews of the second edition:

"The book provides a comprehensive view in the field of apoptosis, senescence, and cancer therapies. I recommend this book to PhD students in clinical and experimental oncology, pharmacology as well as to lecturers in biological disciplines." (J. Sedlák, Neoplasma, September, 2008)

"This book aims to explain basic biological processes and signalling pathways and to link that knowledge to the anticancer drugs associated with those pathways. ... The book is generally well written and extremely informative. The information within is as up to date ... . I have certainly learnt a lot from reading this book. ... recommending it to a laboratory/clinical group or library for purchase." (A Young, British Journal of Cancer, Vol. 100 (5), 2009)

"The purpose of the book is to contribute to an understanding of the growth arrest and cell death pathways mediating the response to chemotherapy in tumour cells. ... provides basic scientists and clinicianswith a deeper and more thorough understanding of the cellular responses of malignant cells to common therapeutic modalities, which may determine the effectiveness of the anti-cancer treatment. This work is an interesting overview of the topics described above and it is well written by experts in the field." (Sylvie Rottey, Acta Clinica Belgica, Vol. 65 (2), 2010)