Tight Junctions provides a state-of-the-art view on Tight Junctions (TJs). Starting with an analysis of the evolutionary development of a transporting epithelium in early metazoans, the book describes the current TJ structure and function information, including the present day evidence supporting the presence of ion channels within TJs. Particular emphasis is given to the lessons learned from cell culture models, mutant mice and heritable human diseases. To highlight the modern vision of TJs as signaling complexes, the book discusses the establishment of TJs during development, the shuttling of TJ proteins between the plasma membrane and the nucleus, and the role of TJ proteins in cell cycle progression and cancer. TOC:The Evolution of Transporting Epithelium Phenotype.- Occludin, a Constituent of Tight Junctions.- Tight Junction Channels.- JAM Family Proteins: Tight Junction Proteins That Belong to the Immunoglobulin Superfamily.- Cingulin, A Cytoskeleton-Associated Protein of the Tight Junction.- ZO Proteins and Tight Junction Assembly.- TJ Proteins That Make Round Trips to the Nucleus.- Tight Junctions and the Regulation of Epithelial Cell Proliferation and Gene Expression.- Tight Junction Proteins and Cancer.- Regulation of Paracellular Transport across Tight Junctions by the Actin Cytoskeleton.- Regulation of Tight Junctions' Functional Integrity: Role of a Urinary Factor, Lipids and Ouabain.- Tight Junctions during Development.- Tight Junctions and the Blood-Brain Barrier.- Tight Junctions in CNS Myelin.- Tight Junction Modulation and Its Relationship to Drug Delivery.- Index.
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