Endocannabinoids control most of the body functions, and in the brain, they modulate neurotransmission, synaptic plasticity, confer neuroprotection, control metabolism, neuro- and neuritogenesis, survival, cognitive and motor functions as well as a plethora of other higher-order brain functions. Their fruitful therapeutic potential is recognized by cannabinoid researchers and pharmaceutical companies, respectively. The aim of this book is to help clinicians, neuroscientists, as well as students, understand the significance of the endocannabinoid system. This book, however, also will be very useful to those who already feel comfortable with the neuroscience of endocannabinoids. The book will introduce the reader to the "up-to-date" neurobiology of endocannabinoids and related systems, and will detail their pathophysiological role and therapeutic potential. Authors involved in clinical investigations present results of recent clinical trials, and the development of new therapeutic strategies and medicines. TOC:Part I Molecular biology, pharmacology, anatomy, and physiology of the encocannabinoid and related lipidergic signaling systems in the brain: An historical introduction to the endocannabinoid and endovanilloid systems.-Biosynthesis of anandamide and 2-arachidonolyglycerol.-Removal of endocannabinoids by the body-mechanisms and therapeutic possibilities.-Other cannabimimetic lipid signaling molecules.-CB1 cannabinoid receptors: molecular biology, second messenger coupling and polarized trafficking in neurons.-CB2 cannabinoid receptors: molecular, signaling and trafficking properties.-CB1 and CB2 receptor pharmacology.-Functional molecular biology of the TRPV1 channel.-Alternative interacting sites and novel receptors for cannabinoid ligands.-Anatomical distribution of receptors, ligands and enzymes in the brain and in the spinal cord: circuitries and neurochemistry.-Endocannabinoids at the synapse-retrograde signaling and presynaptic plasticity in the brain.-Endocannabinoid functions in neurogenesis, neural migration and specification.-Part II The endocannabinoid system in clinical neuroscience and experimental neursopsychiatry: Cannabinoids in the management of nausea and vomiting.-Endocannabinoids in energy homeostasis and metabolic disorders.-Cannabinoids and neuroprotection.-Neuroinflammation and the glial endocannabinoid system.-Targeting cannabinoid receptors in brain tumors.-Cannabinoids for the control of multiple sclerosis.-Endocannabinoids in Alzheimer's disease.-The endocannabinoid system as a therapeutic target in epilepsy.-The endocannabinoid system in the physiology and pathology of the basal ganglia.-The endocannabinoid system is a major player in schizophrenia.-The cannabinoid controversy: cannabinoid agonists and antagonists as potential novel therapies for mood disorders.-Role of cannabinoid receptors in anxiety disorders.
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