Immunosenescence (eBook, PDF)

Redaktion: Pawelec, Graham

• Format: PDF

Produktbeschreibung

Human immunosenescence contributes to morbidity and mortality in later life. Understanding the reasons for age-associated alterations to protective immunity in the elderly would ultimately improve and extend healthspan. The majority of the papers collected in this remarkable and timely volume address the mechanisms responsible for immune ageing in humans. They also consider what might be accomplished to redress the erosion of immune competence with age.

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Produktdetails

• Verlag: Springer-Verlag GmbH
• Seitenzahl: 194
• Erscheinungstermin: 18. Dezember 2008
• Englisch
• ISBN-13: 9780387768427
• Artikelnr.: 37285371

Inhaltsangabe

1. Immune Risk Phenotypes and Associated Parameters in Very OldHumans: A Review of Findings in the Swedish NONA ImmuneLongitudinal Study........................................................................................1Anders Wikby, Frederick Ferguson, Jan Strindhall, Rosalyn J. Forsey,Tamas Fulop, Sine Reker Hadrup, Per thor Straten, Graham Pawelecand Boo JohanssonIntroduction................................................................................................................1NONA Immune Subjects........................................................................................3Health Parameters.....................................................................................................4Immune System Parameters.....................................................................................4Immune Parameters and Morbidity......................................................................4Immune Risk Phenotype, Cognitive Impairment and Mortality..................5Allostatic Load............................................................................................................6IRP, T-Cell Differentiation and Persistent Viral Infection..............................7TCR Clonotype Mapping......................................................................................10Low Grade Inflammation......................................................................................11IRP Movement..........................................................................................................11Conclusions and Future Direction.......................................................................122. Scoring of Immunological Vigor: Trial Assessment of Immunological Statusas a Whole for Elderly People and Cancer Patients....................................15Katsuiku Hirokawa, Masanori Utsuyama, Yuko Kikuchiand Masanobu KitagawaInfection Is a Major Cause of Death in the Elderly..........................................15A Significant Number of Cancer Patients Die of Infection...........................16Assessment of the Immunological State.............................................................18Restoration of Immune Function........................................................................ 20Effect of Infusing Activated T-Cells in the Mouse Model.............................213. Remodelling of the CD8 T-Cell Compartment in the Elderly: Expressionof NK Associated Receptors on T-Cells Is Associated with the Expansionof the Effector Memory Subset....................................................................24Inmaculada Gayoso, M Luisa Pita, Esther Peralbo, Corona Alonso,Olga DelaRosa, Javier G. Casado, Julian de la Torre-Cisneros,Raquel Tarazona and Rafael SolanaIntroduction............................................................................................................. 24Expression of NKR on T-Cells in Ageing: The Expansion of CD8 T-CellsExpressing NK Associated Receptors in the Elderly Is due to theExpansion of Effector Memory 2 T-Lymphocytes.......................................25CMV-Specific CD8 T-Cells Are Expanded in the Elderly Expression ofNK Associated Receptors................................................................................. 28Concluding Remarks and Future Prospects..................................................... 304. Telomeres, Telomerase and CD28 in Human CD8 T-cells: Effectson Immunity during aging and HIV infection..........................................34Steven R. Fauce and Rita B. Effr

Rezensionen

From the reviews:

"The book covers the basic biology of cell-mediated immunity decline, the consequences of the declined immune system, and interventional therapeutic approaches aiming to correct or reverse the aged immune system. ... The book ends with insightful review on therapeutic strategies aiming to correct or reverse immunosenescence. Overall, the book is very well written and should be recommended reading for cell biologists, immunologists, and physician scientists interested in the current scope of understanding immunosenscence and opportunities to explore therapeutic strategies for its correction." (Yang Zhou, Clinical Infectious Diseases, December, 2012)