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Insulin-like growth factor (IGF)-I is a widely expressed growth factor with diverse effects on many tissues throughout development and in adult life. The purpose of this work is to provide detailed and updated information on the role of the growth hormone (GH)-IGF axis in fetal and postnatal development, as well as its physiological functions and implications in pathology. TOC:Introduction.- Placenta and early embryonic development.- Experimental models.- Evolution, aging, life span.- Brain development.- Development of sensory organs.- Neuroplasticity and neuroprotection.- Reproductive tract.-…mehr

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Produktbeschreibung
Insulin-like growth factor (IGF)-I is a widely expressed growth factor with diverse effects on many tissues throughout development and in adult life. The purpose of this work is to provide detailed and updated information on the role of the growth hormone (GH)-IGF axis in fetal and postnatal development, as well as its physiological functions and implications in pathology. TOC:Introduction.- Placenta and early embryonic development.- Experimental models.- Evolution, aging, life span.- Brain development.- Development of sensory organs.- Neuroplasticity and neuroprotection.- Reproductive tract.- Skeletal muscle.- Cardiovascular system-lung.- Hematopoiesis.- Pancreas development and glucose regulation.- IGF interaction with other trophic factors.- Cancer.- Human genetics of the GH-IGF-I axis.- Future perspectives-stem cells.- Index

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Autorenporträt
Isabel Varela-Nieto, CSIC-UAM; Madrid, Spain / Julie Ann Chowen, Hospital Universitario Nino Jesus, Madrid, Spain