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This book focuses on what we currently know about the environment, genetics and mechanisms that lead to retinal degenerations, new diagnostics, and innovative therapeutic modalities to preserve vision. TOC:Living With Retinal Degeneration Coping with Retinitis Pigmentosa: A Patient's View.- Degenerative Diseases of the Retina: Epidemiology of ARMD Early in the 21st Century.- Leber Congenital Amaurosis: Biology, Diagnostics, and Therapeutics.- Macular Degeneration: Aging Changes and Novel Therapies.- Stargardt Disease: From Gene Discovery to Therapy.- X-Linked Juvenile Retinoschisis.- Retinal…mehr

Produktbeschreibung
This book focuses on what we currently know about the environment, genetics and mechanisms that lead to retinal degenerations, new diagnostics, and innovative therapeutic modalities to preserve vision. TOC:Living With Retinal Degeneration Coping with Retinitis Pigmentosa: A Patient's View.- Degenerative Diseases of the Retina: Epidemiology of ARMD Early in the 21st Century.- Leber Congenital Amaurosis: Biology, Diagnostics, and Therapeutics.- Macular Degeneration: Aging Changes and Novel Therapies.- Stargardt Disease: From Gene Discovery to Therapy.- X-Linked Juvenile Retinoschisis.- Retinal Degeneration in Usher Syndrome.- Mouse Models of RP.- Mechanisms Underlying Retinal Degenerations: The Impact of Diabetes on Neuronal, Glial and Vascular Cells of The Retina: Implications For The Pathogenesis of Diabetic Retinopathy.- Statins and Age-Related Maculopathy.- The Role of Drusen in Macular Degeneration and New Methods of Quantification.- RPE Lipofuscin: Formation, Properties, and Relevance to Retinal Degeneration.- Genetic Modifiers That Affect Phenotypic Expression of Retinal Diseases.- X-Linked Retinal Dystrophies and Microtubular Functions within the Retina.- Synaptic Remodeling in Retinal Degeneration.- Developing Therapeutic Strategies for Retinal Degenerative Diseases on the Suppression of Photoreceptor Cell Death in Retinitis Pigmentosa.- Cell-Based Therapies to Restrict to Progress of Photoreceptor Degeneration.- Current Status of IPE Transplantation and its Potential as A Cell-Based Therapy for Age-Related Macular Degeneration and Retinal Dystrophies.- Recent Results in Retinal Transplantation Give Hope for Restoring Vision.- Stem Cells and Retinal Transplantation.- Application of Encapsulated Cell Technology for Retinal Degenerative Diseases.- Effective Treatment for the Canine RPE65 Null Mutation, A Hereditary Retinal Dystrophy Comparable to Human Leberís Congenital Amaurosis.- The Use of Neuroprotective Factors In Retinal Degenerations.- Carbonic Anhydrase Inhibitors as A Possible Therapy for RP17, an Autosomal Dominant Retinitis Pigmentosa Associated with the R14W Mutation, Apoptosis, and the Unfolded Protein Response.

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  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 06.11.2007
  • Englisch
  • ISBN-13: 9781597451864
  • Artikelnr.: 52637924
Autorenporträt
Joyce Tombran-Tink, University of Missouri-Kansas City, Kansas City, MO, USA / Colin J. Barnstable, Yale University, School of Medicine, New Haven, CT, USA
Inhaltsangabe
Retinal Degenerations: Genetics, Progression, and Therapeutics - Table of Contents J Tombran-Tink and CJ Barnstable (eds) University of Missouri-Kansas City and Yale University School of Medicine 1. Living with Retinal Degeneration Coping with Retinitis Pigmentosa: A Patientís View Gordon Cousins and James Cape 2. Degenerative Diseases of the Retina Epidemiology of ARMD Early in the 21st Century Jie Jin Wang, Paul Mitchell and Ronald Klein 3. Leber Congenital Amaurosis: Biology, Diagnostics, and Therapeutics Robert K. Koenekoop 4. Macular Degeneration. Aging Changes and Novel Therapies Peter E. Liggett and Alejandro J. Lavaque 5. Stargardt Disease: from gene discovery to therapy Rando Allikmets 6. X-Linked Juvenile Retinoschisis Bernhard H.F. Weber and Ulrich Kellner 7. Retinal Degeneration in Usher Syndrome David S. Williams 8. Mouse models of RP Bo Chang, Norman L. Hawes, Muriel T. Davisson, J.R. Heckenlively 9. Mechanisms underlying retinal degenerations The Impact of Diabetes on Neuronal, Glial and Vascular Cells of the Retina: Implications for the Pathogenesis of Diabetic Retinopathy Sylvia B. Smith 10. Statins and Age-Related Maculopathy Gerald McGwin Jr. and Cynthia Owsley 11. The role of Drusen in Macular Degeneration and New Methods of Quantification R. Theodore Smith and Umer F. Ahmad 12. RPE lipofuscin: Formation, Properties, and Relevance to Retinal Degeneration Janet R. Sparrow 13. Genetic Modifiers that Affect Phenotypic Expression of Retinal Diseases Malia M. Edwards, Dennis M. Maddox, Jungyeon Won, J rgen K. Naggert and Patsy M. Nishina 14. X-linked retinal dystrophies and microtubular functions within the retina Alan Wright and Xinhua Shu 15. Synaptic Remodeling in RetinalDegeneration You-Wei Peng and Fulton Wong 16. Developing Therapeutic Strategies for Retinal Degenerative Diseases On The Suppression of Photoreceptor Cell Death in Retinitis Pigmentosa Fiona Kernan, Alex G. McKee, G. J. Farrar and Peter Humphries 17. Cell-based therapies to restrict to progress of photoreceptor degeneration Raymond D. Lund and Shaomei Wang 18. Current Status of IPE Transplantation and its Potential as a Cell-Based Therapy for Age-Related Macular Degeneration and Retinal Dystrophies Makoto Tamai 19. Recent results in Retinal Transplantation give hope for restoring vision Robert B. Aramant, Norman D. Radtke and Magdalene J. Seiler 20. Stem Cells and Retinal Transplantation Joanne Yau, Henry Klassen, Tasneem Zahir and Michael Young 21. Application of Encapsulated Cell Technology for Retinal Degenerative Diseases Weng Tao and Rong Wen 22. Effective treatment for the canine RPE65 null mutation, a hereditary retinal dystrophy comparable to human Leberís Congenital Amaurosis Kristina Narfstrm, Gregory E. Tullis and Mathias Seeliger 23. The Use of Neuroprotective Factors in Retinal Degenerations Joyce Tombran-Tink and Colin Barnstable 24. Carbonic anhydrase inhibitors as a possible therapy for RP17, an Autosomal Dominant Retinitis Pigmentosa associated with the R14W mutation, apoptosis, and the unfolded protein response. George Rebello, Jacquie Greenberg and Raj Ramesar
Rezensionen
From the reviews:

"This book is a comprehensive review of the retinal degenerations, focusing particularly on a range of macular degenerations and the inherited retinal dystrophies. ... is essential reading for even the experienced low vision clinician and anyone wishing to understand the difficulties faced by patients who are diagnosed with sight-threatening retinal conditions. ... will be of interest to research groups. ... This is a valuable book and is essential for low vision clinicians. I recommend it to any optometrist with a particular interest in retinal disease." (Michael Kalloniatis, Clinical and Experimental Optometry, Issue 91, November, 2008)