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The product of perhaps the most important research meeting in the field, this essential text outlines all the latest research in retinal degeneration. Culled from the proceedings of the International Symposium on the subject, the topics in this volume explore the etiology, cellular mechanisms, epidemiology, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration. A must-read for researchers in the field.…mehr

Produktbeschreibung
The product of perhaps the most important research meeting in the field, this essential text outlines all the latest research in retinal degeneration. Culled from the proceedings of the International Symposium on the subject, the topics in this volume explore the etiology, cellular mechanisms, epidemiology, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration. A must-read for researchers in the field.


Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GB, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

  • Produktdetails
  • Verlag: Springer New York
  • Erscheinungstermin: 03.12.2007
  • Englisch
  • ISBN-13: 9780387749044
  • Artikelnr.: 37286256
Inhaltsangabe
Preface.- About The Editors.- Travel Awardees.- Part I Keynote Lectures.- Curing Blindness With Stem Cells: Hope, Reality, And Challenges.- Retinal Degenerations: Planning For The Future.- Part Ii Neuroprotection.- Neurotrophins Induce Neuroprotective Signaling In The Retinal Pigment Epithelial Cell By Activating The Synthesis Of The Anti-Inflammatory And Anti-Apoptotic Neuroprotectin D1.- On The Role Of Cntf As A Potential Therapy For Retinal Degeneration.- Nanoceria Particles Prevent Roi-Induced Blindness.- An In-Vivo Assay To Identify Compounds Protective Against Light Induced Apoptosis.- Role Of Bcl-Xl In Photoreceptor Survival.- The Hypoxic Transcriptome Of The Retina.- Part Iii Gene Therapy And Neuroprotection.- Lentiviral Gene Transfer-Mediated Cone Vision Restoration In Rpe65 Knockout Mice.- In Vitro Analysis Of Ribozyme-Mediated Knockdown Of An Adrp Associated Rhodopsin Mutation.- Gene Therapy For Mouse Models Of Adrp.- Development Of Viral Vectors With Optimal Transgene Expression For Ocular Gene Therapies.- Adeno-Associated Viral Vectors And The Retina.- Genetic Supplementation Of Rds Alleviates A Loss-Of-Function Phenotype In C214s Model Of Retinitis Pigmentosa.- Morphological Aspects Related To Long-Term Functional Improvement Of The Retina In The 4 Years Following Raav-Mediated Gene Transfer In The Rpe65 Null Mutation Dog.- Virus-Mediated Gene Delivery To Neuronal Progenitors.- Part Iv Animal Models Of Retinal Degeneration.- Loss Of Visual And Retinal Function In Light-Stressed Mice.- Erg Responses And Microarray Analysis Of Gene Expression In A Multifactorial Murine Model Of Age-Related Retinal Degeneration.- Oxygen Supply And Retinal Function: Insights From A Transgenic Animal Model.- Characterization Of Gene Expression Profiles Of Normal Canine Retina And Brain Using A Retinal Cdna Microarray.- Toward A Higher Fidelity Model Of Amd.- The Potential Of Ambient Light Restriction To Restore Function To The Dengerating P23h-3 Rat Retina.- Part V Molecular Genetics And Candidate Genes.- Mutations In Known Genes Account For 58% Of Autosomal Dominant Retinitis Pigmentosa (Adrp).- Genetics Of Age-Related Macular Degeneration.- Retinal Phenotype Of An X-Linked Pseudo-Usher Syndrome In Association With The G173r Mutation In The Rpgr Gene.- Mutation In The Pyk2-Binding Domain Of Pitpnm3 Causes Autosomal Dominant Cone Dystrophy (Cord5) In Two Swedish Families.- Identification And Characterization Of Genes Expressed In Cone Photoreceptors.- Clinical And Genetic Characterization Of A Chinese Family With Csnb1.- 10q26 Is Associated With Increased Risk Of Age-Related Macular Degeneration In The Utah Population.- Part Vi Diagnostic, Clinical, Cytopathological And Physiologic Aspects Of Retinal Degeneration.- Carboxyethylpyrrole Adducts, Age-Related Macular Degeneration And Neovascularization.- A Possible Impaired Signaling Mechanism In Human Retinal Pigment Epithelial Cells From Patients With Macular Degeneration.- Expression and Cell Compartmentalization of Efemp1, A Protein Associated with Malattia Leventinese.- Role of Elovl4 in Fatty Acid Metabolism.- Organization and Molecular Interactions of Retinoschisin in Photoreceptors.- Part VII Basic Science Underlying Retinal Degeneration.- Proteomics Profiling of the Cone Photoreceptor Cell Line, 661W.- G -Secretase Regulates Vegfr-1 Signalling in Vascular Endothelium and RPE.- Analysis of the Rate of Disk Membrane Digestion by Cultured RPE Cells.- Functional Expression of Cone Cyclic Nucleotide-Gated Channel in Cone Photoreceptor-Derived 661W Cells.- Phosphorylation of Caveolin-1 in Bovine Rod Outer Segments in Vitro by an Edogenous Tyrosine Kinase.- Regulation of Neurotrophin Expression and Activity in the Retina.- Involvement of Guanylate Cyclases in Transport of Photoreceptor Peripheral Membrane Proteins.- Rod Progenitor Cells in the Mature Zebrafish Retina.- Avß5 Integrin Receptors at the Apical Surface of The RPE: One Receptor, Two Functions.- Implantation of Mouse Eyes
Rezensionen
From the reviews:

"This edited book is the proceedings of the symposium on Retinal Degeneration ... . The purpose is to disseminate the latest research findings in the field of retinal degenerations from the symposium participants ... . The book is written for scientists and trainees in the field of retinal degenerations. The editors are experts in this field and many of the chapter authors are experts in their respective areas. ... This is a must-have reference for the shelf of scientists interested in retinal degeneration." (Artur V Cideciyan, Doody's Review Service, April, 2008)