Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease. An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and future therapies.Heart Failure: Bench to Bedside includes a primer on gene profiling and bioenergetics of the normal heart and a discussion of the…mehr
Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease. An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and future therapies.Heart Failure: Bench to Bedside includes a primer on gene profiling and bioenergetics of the normal heart and a discussion of the molecular, genetic, biochemical and cellular techniques critical to understanding HF. Further chapters discuss cardiac remodeling, oxidative stress, and alterations in other organs and systems that are often associated with HF. This book thoughtfully evaluates current and forthcoming diagnostic techniques and therapies, pharmaceutical and pharmacogenomic-based individualized medicine, gene and cell-based therapies, and the search for new frontiers.Heart Failure: Bench to Bedside presents a clear view of up-to-date approaches to clinical diagnosis and treatment, as well as offering insightful critiques of original and creative scientific thoughts on post-genomic HF research.
PrefaceSection IClinical, Physiology and Genetics Changes in Heart Failure1. Introduction to Heart Failure2. Cardiac Function in Heart Failure: The Role of Calcium Cycling3. Gene Profiling of the Failing Heart - EpigeneticsSection IIBiochemical and Molecular Changes in Heart Failure4. Bioenergetics and Metabolic Changes in the Failing HeartSection IIIThe Mitochondrial Organelle and the Heart5. The Multidimensional Role of Mitochondria in Heart FailureSection IVExperimental Models of Heart Failure6. Animal Models of Heart FailureSection VSignaling, Stress and Cellular Changes in Heart Failure7. Signaling Cascades in Heart Failure: From Cardiomyocytes Growth and Survival to Mitochondrial Signaling Pathways8. Cyclic Nucleotides Signaling (Second Messengers) and Control of Myocardial Function: Effects of Heart Failure9. Calcium Signaling. Receptors, Effectors and other Signaling Pathways10. Oxidative Stress and Heart Failure11. Remodeling and Cellular Death in the Failing HeartSection VIPeripheral Changes and Co-morbid Conditions in Heart Failure12. Heart failure and changes at the periphery: Vascular, Inflammation, Neurohormonal and Renal systems13. Comorbidities in Heart FailureSection VIIHeart Failure in Children14. Mechanisms and Clinical Recognition and Management of Heart Failure in Infants and Children15. Mechanical Circulatory Support and Heart Transplantation in Children with Severe Refractory Heart FailureSection VIIIAging and the Failing Heart16. Basic Mechanisms Mediating Cardiomyopathy and Heart Failing in Aging17. Heart Failure of Aging. Clinical ConsiderationsSection IXDiagnostic Methodology in Heart Failure18. Diagnosis of Heart Failure. Evidence-Based Perspective19. 'Omics' Application in Heart Failure: Novel Diagnostic and Prognostic Markers to Understand Pathophysiology and Finding New TherapiesSection XAvailable and Forthcoming Therapies for Heart Failure20. Treatment of Chronic Heart Failure21. GeneTherapy in Heart Failure: Forthcoming Therapies22. Myocardial Cell-Based Regeneration in Heart Failure
From the reviews:
"A clear and comprehensive review is desperately needed to lessen the time readers spend searching the Internet or rummaging through massive numbers of clinical trials. ... the text still can appeal to any health science student, physician-in-training, practicing physician, and of course, cardiologist. In fact, this text is strongly recommended for cardiologists pursuing additional training in cardiac transplantation and care of advanced heart failure. ... This book will serve as a useful reference and could become a powerful tool for cardiology ... ." (Joseph Sam Owen, Journal of the American Medical Association, February, 2011)
"This book tackles a broad array of topics in heart failure in an organized manner. ... most useful to specialists in heart failure, especially those with an interest in molecular and cell biology research, or those interested in translating basic science research into clinical investigations. The book will be of interest to cardiologists in training as well as adult and pediatric cardiologists. ... It is unique as it adds gene expression and how it may play a role in the heart failure disease process." (Joaquin Crespo, Doody's Review Service, September, 2010)
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