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Since this book is geared to be used by varied groups of readers such as advanced students and instructors in the fields of biology and medicine, scientists and more importantly clinicians, it is considered important to provide brief accounts of the basics of DNA damage, repair, mutagenesis and cancer. The purpose of this book is to present an updated detailed account of some important additional diseases of DNA repair. It has not been possible to cover all the DNA repair deficient diseases in this volume, hence diseases such as Bloom's syndrome, Werner's syndrome, Nijmegen breakage syndrome,…mehr

Produktbeschreibung
Since this book is geared to be used by varied groups of readers such as advanced students and instructors in the fields of biology and medicine, scientists and more importantly clinicians, it is considered important to provide brief accounts of the basics of DNA damage, repair, mutagenesis and cancer. The purpose of this book is to present an updated detailed account of some important additional diseases of DNA repair. It has not been possible to cover all the DNA repair deficient diseases in this volume, hence diseases such as Bloom's syndrome, Werner's syndrome, Nijmegen breakage syndrome, ataxia telangiectasia_like disorder, RA D 50 deficiency, RIDDLE syndrome and others will be presented in a forthcoming volume.
  • Produktdetails
  • Advances in Experimental Medicine and Biology Vol.685
  • Verlag: Springer, Berlin
  • Artikelnr. des Verlages: 80013256, 978-1-4419-6447-2
  • 2010
  • Erscheinungstermin: Juli 2010
  • Englisch
  • Abmessung: 260mm x 173mm x 23mm
  • Gewicht: 620g
  • ISBN-13: 9781441964472
  • ISBN-10: 1441964479
  • Artikelnr.: 29016953
Autorenporträt
Shamim Ahmad after obtaining his Master's degree in Botany from Patna University, Bihar, India and his PhD in Molecular Genetics from Leicester University, England, joined Nottingham Polytechnic as Grade 1 lecturer and subsequently promoted to SL post. Nottingham Polytechnic subsequently became Nottingham Trent University where, after serving for about 35 years, he took early retirement to spend the remaining time writing books and conducting full-time research. For more than three decades he worked on different areas of biology including thymineless death in bacteria, genetic control of nucleotide catabolism, development of anti-AIDS drugs, control of microbial infection of burns, phages of thermophilic bacteria and microbial flora of Chernobyl after nuclear accident. But his primary interest, which started 25 years ago, is DNA damage and repair, particularly near UV photolysis of biological compounds, production of reactive oxygen species and their implications on human health including skin cancer and xeroderma pigmentosum. He is also investigating photolysis of non-biological compounds such as 8-methoxypsoralen+UVA, mitomycin C, and nitrogen mustard and their importance in psoriasis treatment and in Fanconi anemia. In 2003 he received a prestigious "Asian Jewel Award" in Britain for "Excellence in Education". He is also the Editor of Molecular Mechanisms of Fanconi Anaemia, Molecular Mechanisms of Xeroderma Pigmentosum, Molecular Mechanisms of Ataxia Telangiectasia and Molecular Mechanisms of Cockayne Syndrome published by Landes Bioscience.
Inhaltsangabe
1. Triple?A SyndromeVijaya Sarathi and Nalini S. ShahAbstractIntroductionEpidemiologyEtiologyPathologyDiagnosisDifferential DiagnosisTreatmentConclusion2. Amyotrophic Lateral SclerosisJ. Jefferson P. Perry, David S. Shin and John A. TainerAbstractIntroductionClinical FeaturesGenetic Basis and the Molecular Mechanism of the DiseaseCu,ZnSODTDP?43FUS/TLSConclusion3. Early?Onset Ataxia with Ocular Motor Apraxia and Hypoalbuminemia/Ataxia with Oculomotor Apraxia 1Masayoshi Tada, Akio Yokoseki, Tatsuya Sato, Takao Makifuchi and Osamu OnoderaAbstractIntroductionEpidemiologyGenetics of EAOH/AOA1Clinical FeaturesPathogenesisConclusion4. Clinical Features and Pathogenesis of Alzheimer's Disease: Involvementof Mitochondria and Mitochondrial DNAMichelangelo Mancuso, Daniele Orsucci, Annalisa LoGerfo, Valeria Calsolaroand Gabriele SicilianoAbstractAlzheimer's DiseaseMitochondrial Structure and FunctionOxidative Stress and Mitochondrial Dysfunction in ADThe Role of Mitochondrial DNAConclusion5. Huntington's DiseaseEmmanuel Roze, Cecilia Bonnet, Sandrine Betuing and Jocelyne CabocheAbstract HistoryClinical AspectsGenetic AspectsNeuropathologyMolecular MechanismsConclusion6. Clinical Features and MolecularMechanisms of Spinal and BulbarMuscular Atrophy (SBMA)Masahisa Katsuno, Haruhiko Banno, Keisuke Suzuki, Hiroaki Adachi,Fumiaki Tanaka and Gen SobueAbstractClinical FeaturesGenetic BasisHistopathologyMolecular MechanismsTherapeutic StrategiesConclusion7. Spinocerebellar Ataxia with Axonal NeuropathyCheryl Walton, Heidrun Interthal, Ryuki Hirano, Mustafa A.M. Salih,Hiroshi Takashima and Cornelius F. BoerkoelAbstractIntroductionSymptoms of SCAN1Genetic Basis of SCAN1Tdp1 FunctionMolecular Basis of SCAN1Current and Future ResearchConclusion8. Tuberous Sclerosis Complex and DNA RepairSamy L. HabibAbstractIntroduction: Clinical Manifestations of TSC DiseaseRenal Lesions in TSC?Deficient MammalsTSC1and TSC2 GenesTSC Genes and Cell SignalsTSC and DNA Damage/Repair PathwayTSC2 Regulates DNA Damage/Repair PathwayConclusion9. Hereditary PhotodermatosesDennis H. Oh and Graciela SpivakAbstractIntroductionMetabolic PhotodermatosesHereditary Photodermatoses of Unknown Etiology or PathogenesisDefects in Cancer Suppressor GenesHuman Syndromes Defective in DNA RepairUV?Sensitive Syndrome (UVSS)Conclusion10. Trichothiodystrophy: Photosensitive, TTD?P, TTD, Ta y SyndromeW. Clark Lambert, Claude E. Gagna and Muriel W. LambertAbstractClinical ManifestationsXeroderma Pigmentosum/Trichothiodystrophy Overlap SyndromeCockayne Syndrome/Trichothiodystrophy Overlap SyndromeEtiopathogenesisLaboratory DiagnosisAnimal ModelConclusion 11. Cornelia de Lange SyndromeJinglan Liu and Gareth BaynamAbstractClinical CharacteristicsMolecular Genetics of CdLSConclusion12. Rectal Cancer and Importance of Chemoradiation in the TreatmentSergio HuertaAbstractIntroductionRectal Cancer: Metastasis and Survival RatesMechanisms of Cell Death By Ionizing RadiationMechanisms of Resistance to Radiation in Rectal CancerProliferation Markers and Mitotic Index (Ki?67)p53, p21 and p27 and Apoptotic Index (AI)ApoptosisNF?BInhibitors of Apoptosis (IAPs: Survivin)Conclusion13. Familial Cutaneous MelanomaJohan HanssonAbstractIntroductionRisk Factors for MelanomaFamilial Melanoma-The Clinical PictureMolecular Genetics of Familial Cutaneous MelanomaHigh Risk Melanoma GenesCandidate Loci for Novel Genes Predisposing to Familial CMRisk of Melanoma and Other Cancers in Melanoma Families with Germline CDKN2A MutationsGenetic Testing in Familial MelanomaManagement of Familial MelanomaPrimary PreventionSecondary Prevention of CMPancreatic Carcinoma SurveillanceConclusion14. Primary Immunodeficiency SyndromesMary A. Slatter and Andrew R. GenneryAbstractIntroductionRole of DNA Repair Proteins in Adaptive ImmunityGenetic Defects Associated with