Wolfgang L. Gross (Hrsg.)

ANCA-Associated Vasculitides

Immunological and Clinical Aspects
Herausgegeben:Gross, Wolfgang L.

• Gebundenes Buch

Produktbeschreibung

WEGENER'S GRANULOMATOSIS & ANCA-ASSOCIATED DISEASES: THE STORY CONTINUES The disease now designated as Wegener's granulomatosis (WG) was first described in 1931 by Heinz Klinger, who considered it to be a special form of polyarteritis nodosa. Klinger's friend, Friedrich Wegener, expanded on the first observations and interpreted the pathological and clinical fmdings to represent a distinct disease entity (Wegener, 1939). He described this entity as a "peculiar rhinogenous granulomatosis with a unique participation of the arterial system and the kidneys". Later, Godman and Churg (1954) established the classical diagnostic criteria (the "WG triad"): granuloma, vasculitis, and glomerulonephritis. In 1958 Walton pointed out the poor prognosis of WG based on a small number of published cases (mean survival time: 5 months). In 1966 Carrington and Liebow reported "limited forms" of WG with a defmitely more favorable prognosis. Since then positive results have been reported with cyclophosphamide therapy. In addition, a retrospective study of combined low-dose cyclophosphamide and prednisolone in 85 WG patients over a period of 21 years found a similarly encouraging outcome. The·latter experience led to the current "standard" treatment protocol (FAUCI et al. , 1973 and 1983). More recently, strong evidence has emerged that some of the morbidity and mortality ofWG - and other types of systemic vasculitis - may be a consequence of this treatment (Hoffman et al. , 1992).

Produktdetails

• Advances in Experimental Medicine and Biology 336
• Verlag: Springer / Springer US / Springer, Berlin
• Artikelnr. des Verlages: 978-0-306-44573-6
• 1993.
• Seitenzahl: 576
• Erscheinungstermin: 30. November 1993
• Englisch
• Abmessung: 241mm x 160mm x 36mm
• Gewicht: 980g
• ISBN-13: 9780306445736
• ISBN-10: 0306445735
• Artikelnr.: 20953318

Inhaltsangabe

Friedrich Wegener and the Nature of Fame.- Pathophysiological Aspects and Antigen Specificity.- Clinical Aspects of Wegener's Granulomatosis and other ANCA-Associated Diseases.