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ATP, the intracellular energy source, is also an extremelyimportant cell-cell signalling molecule for a wide variety ofcells across evolutionarily diverse organisms. The extracellularbiochemistry of ATP and its derivatives is complex, and themultiple membrane receptors that it activates are linked to manyintracellular signalling systems. Purinergic signalling affects a diverse range of cellularphenomena, including ion channel function, cytoskeletal dynamics,gene expression, secretion, cell proliferation, differentiation andcell death. Recently, this class of signalling molecules andreceptors…mehr

Produktbeschreibung
ATP, the intracellular energy source, is also an extremelyimportant cell-cell signalling molecule for a wide variety ofcells across evolutionarily diverse organisms. The extracellularbiochemistry of ATP and its derivatives is complex, and themultiple membrane receptors that it activates are linked to manyintracellular signalling systems. Purinergic signalling affects a diverse range of cellularphenomena, including ion channel function, cytoskeletal dynamics,gene expression, secretion, cell proliferation, differentiation andcell death. Recently, this class of signalling molecules andreceptors has been found to mediate communication between neuronsand non-neuronal cells (glia) in the central and peripheral nervoussystems. Glia are critical for normal brain function, developmentand response to injury. Neural impulse activity is detected by gliaand purinergic signalling is emerging as a major means ofintegrating functional activity between neurons, glia and vascularcells in the nervous system. These interactions mediate effects ofneural activity on the development of the nervous system and inassociation with injury, neurodegeneration, myelination andcancer. Bringing together contributions from experts in diverse fields,including glial biologists, neurobiologists and specialists inpurinergic receptor structure and pharmacology, this book considershow extracellular ATP acts to integrate communication betweendifferent types of glia, and between neurons and glia. Beginning with an overview of glia and purinergic signalling, itcontains detailed coverage of purine release, receptors andreagents, purinergic signalling in the neural control of glialdevelopment, glial involvement in information processing, anddiscussion of the interactions between neurons and microglia.

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  • Produktdetails
  • Verlag: John Wiley & Sons
  • Seitenzahl: 302
  • Erscheinungstermin: 1. Mai 2006
  • Englisch
  • ISBN-13: 9780470032237
  • Artikelnr.: 37289694
Autorenporträt
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
Inhaltsangabe
Symposium on Purinergic signalling in neuron-glia interactions
held at the Novartis Foundation
London
7-9 June 2005. Editors: Derek J. Chadwick (Organizer) and Jamie Goode. This symposium was based on a proposal made by R. Douglas Fields. R. Douglas Fields Chair's introduction. Kristjan R. Jessen A brief look at glial cells. Bernard Zalc The acquisition of myelin: a success story. Discussion. Geoffrey Burnstock Purinergic signalling--an overview. Discussion. General discussion I. Kenneth A. Jacobson
Stefano Costanzi
Bhalchandra V. Joshi
Pedro Besada
Dae Hong Shin
Hyojin Ko
Andrei Ivanov and Liaman Mamedova Agonists and antagonists for P2 receptors. Discussion. Eduardo Lazarowski Regulated release of nucleotides and UDP sugars from astrocytoma cells. Discussion. Maria P. Abbracchio and Claudia Verderio Pathophysiological roles of P2 receptors in glial cells. Discussion. General discussion II. Herbert Zimmermann ectonucleotidases in the nervous system. Discussion. Joseph T. Neary
Yuan Kang
You-fang Shi
Minh D. Tran and Ina B. Wanner P2 receptor signalling
proliferation of astrocytes
and expression of molecules involved in cell-cell interactions. Discussion. R. Douglas Fields nerve impulses regulate myelination through purinergic signalling. Discussion. Beth Stevens Cross-talk between growth factor and purinergic signalling regulates Schwann cell proliferation. Discussion. Freddy Jeanneteau and Moses V. Chao Promoting neurotrophic effects by GPCR ligands. Discussion. Eric A. Newman A purinergic dialogue between glia and neurons in the retina. Discussion. Tommaso Fellin
Jai-Yoon Sul
Marcello D'Ascenzo
Hajime Takano
Olivier Pascual and Philip G. Haydon Bidirectional astrocyte-neuron communication: the many roles of glutamate and ATP. Discussion. Keith J. Todd and Richard Robitaille neuron-glia interactions at the neuromuscular synapse. Discussion. General discussion III. Stéphane H.R. Oliet
Aude Panatier and Richard Piet Functional neuronal-glial anatomical remodelling in the hypothalamus. Discussion. Francesco Di Virgilio Purinergic signalling between axons and microglia. Discussion. Kazuhide Inoue ATP receptors of microglia involved in pain. Discussion. Final discussion. Index of contributors. Subject index.