Protein Chaperones and Protection from Neurodegenerative Diseases (eBook, ePUB)

Redaktion: Witt, Stephan N.

• Format: ePub

Produktbeschreibung

How protein chaperones protect cells from neurodegenerative diseases Including contributions from leading experts, Protein Chaperones and Protection from Neurodegenerative Diseases provides an in-depth exploration of how protein chaperones are involved in shielding cells from toxic aggregated or misfolded protein states that cause ALS, Parkinson's, and related diseases. Examining how different protein chaperones ameliorate the toxicity of proteins that are known to cause neurodegenerative damage, the book addresses both research and clinical perspectives on chaperone and anti-chaperone properties. The intersection of molecular chaperones and neurodegeneration is an intensely studied area, partly because of the potential for manipulating the expression of molecular chaperones to thwart the progression of debilitating diseases, and partly because of the ever-aging global population. Discussing the potential to harness the power of protein chaperones, and future directions for research, discovery, and therapeutics, this book is essential reading for scientists working in the fields of biochemistry, molecular medicine, pharmacology and drug discovery, biotechnology and pharmaceutical companies, advanced students, and anyone interested in this cutting-edge topic.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 444
• Erscheinungstermin: 9. September 2011
• Englisch
• ISBN-13: 9781118063897
• Artikelnr.: 37346507

Autorenporträt

Stephan N. Witt is a Professor in the Department of Biochemistry and Molecular Biology at the Louisiana State University Health Sciences Center in Shreveport, Louisiana. He obtained his PhD in biophysical chemistry from the California Institute of Technology. Dr. Witt is a member of the editorial board of Cell Stress and Chaperones. He has served on numerous NIH study sections, has authored over forty scientific publications, and edited a book on using yeast as a model for human disease. His research focuses on identifying genes and small molecules that can be used against Parkinson's disease.

Inhaltsangabe

Preface. Introduction. Contributors. 1 Intrinsically Disordered Chaperones
and Neurodegeneration (Vladimir N. Uversky). 2 Redox Regulation of Protein
Misfolding, Synaptic Damage, and Neuronal Loss in Neurodegenerative
Diseases (Tomohiro Nakamura and Stuart A. Lipton). 3 Chaperone-Mediated
Autophagy and Parkinson's Disease (Marta Martinez-Vicente and Ester Wong).
4 Chaperone and Anti-Chaperone Properties of Synuclein: Implications for
Development, Aging, and Neurodegenerative Disease (Makoto Hashimoto,
Kazuanri Sekiyama, Akio Sekigawa, and Masayo Fujita). 5 The
Ubiquitin-Proteasome System in Neurodegenerative Diseases: More than the
Usual Suspects (Anne Bertolotti). 6 Regulation of the Polyglutamine
Androgen Receptor by the Hsp90/Hsp70-Based Chaperone Machinery (Andrew P.
Lieberman and William B. Pratt). 7 Amyloid Remodeling by Hsp104 (James
Shorter). 8 Chaperone-Dependent Amyloid Assembly and Prion Toxicity (Daniel
W. Summers, Katie J. Wolfe, and Douglas M. Cyr). 9 Modulation of Amyloid
Propagation in Yeast by Hsp70 and its Regulators and Chaperone Partners
(Daniel C. Masison). 10 ALS and the Copper Chaperone CCS (Marjatta Son and
Jeffrey L. Elliott). 11 Emerging Area: TorsinA, a Novel ATP-Dependent
Factor Linked to Dystonia (Michal Zolkiewski and Hui-Chuan Wu). 12
Therapeutics: Harnessing the Power of Molecular and Pharmacological
Chaperones (David S. Gross, Ronald L. Klein and Stephan N. Witt). Index.