Written by authorities in the field, this book provides a "bottom up" approach to studying skin toxicology. Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. The inclusion of global legislation and regulatory aspects on the topic makes this a comprehensive review for every practitioner, clinical researcher in industry and academia, and MSc and PhD student of toxicology. Different sections cover skin structure and function, principles and measurement of skin absorption, clinical…mehr
Written by authorities in the field, this book provides a "bottom up" approach to studying skin toxicology. Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. The inclusion of global legislation and regulatory aspects on the topic makes this a comprehensive review for every practitioner, clinical researcher in industry and academia, and MSc and PhD student of toxicology. Different sections cover skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity and in vitro alternatives. A section on regulatory and legislative aspects includes case studies from the UK that fulfill European Union and US FDA requirements. A glossary provides definitions of technical terms, and the chapters contain an introduction, learning boxes and summary section for ease of use. Includes a chapter on drug delivery through the skin. Addresses risk assessment: a key area for the interpretation of skin absorption data that is rarely covered.
Robert Peter Chilcott, Senior Toxicologist, Chemical Hazards and Poisons Division HQ, Health Protection Agency, Chilton, UK. Shirley Price, Senior Lecturer in Toxicopathology, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK.
Inhaltsangabe
Contents Foreword Preface Acknowledgements List of contributors PART I Introduction 1 Cutaneous anatomy and function Robert P. Chilcott Summary References 2 Biochemistry of the skin Simon C. Wilkinson Summary References 3 Skin photobiology Mark A. Birch-Machin and Simon C. Wilkinson Summary References PART II Skin Absorption 4 Skin as a route of entry Simon C. Wilkinson Summary References 5 Physicochemical Factors Affecting Skin Absorption Keith R. Brain and Robert P. Chilcott Summary References 6 Principles of Diffusion and Thermodynamics W. John Pugh and Robert P. Chilcott Summary References 7 In vivo measurements of skin absorption James C. Wakefield and Robert P. Chilcott Summary References 8 In vitro percutaneous absorption measurements Ruth U. Pendlington Summary References PART III Toxicological Assessment 9 Skin immunology and sensitisation David A. Basketter Summary References 10 In vitro phototoxicity assays Penny Jones Summary References 11 In vitro alternatives for irritation and corrosion assessment Penny Jones Summary References 12 Instruments for measuring skin toxicity Helen Taylor Summary References PART IV Clinical Aspects 13 Introduction to dermatology Manjunatha Kalavala and Alex Anstey Summary 14 Clinical aspects of phototoxicity Anthony D. Pearse and Alex Anstey Summary References 15 Occupational skin diseases Jon Spiro Summary References 16 Prevention of occupational skin disease Chris Packham Summary References PART V Regulatory 17 Occupational skin exposures: legal aspects Chris Packham Summary References 18 Safety assessment of cosmetics: an EU perspective Jo Larner Summary References Appendix 18.1 Additional obligations for cosmetic suppliers 19 Regulatory dermatotoxicology and international guidelines Adam Woolley Summary References 20 Glossary of main terms and abbreviations James C. Wakefield Index
Contents Foreword Preface Acknowledgements List of contributors PART I Introduction 1 Cutaneous anatomy and function Robert P. Chilcott Summary References 2 Biochemistry of the skin Simon C. Wilkinson Summary References 3 Skin photobiology Mark A. Birch-Machin and Simon C. Wilkinson Summary References PART II Skin Absorption 4 Skin as a route of entry Simon C. Wilkinson Summary References 5 Physicochemical Factors Affecting Skin Absorption Keith R. Brain and Robert P. Chilcott Summary References 6 Principles of Diffusion and Thermodynamics W. John Pugh and Robert P. Chilcott Summary References 7 In vivo measurements of skin absorption James C. Wakefield and Robert P. Chilcott Summary References 8 In vitro percutaneous absorption measurements Ruth U. Pendlington Summary References PART III Toxicological Assessment 9 Skin immunology and sensitisation David A. Basketter Summary References 10 In vitro phototoxicity assays Penny Jones Summary References 11 In vitro alternatives for irritation and corrosion assessment Penny Jones Summary References 12 Instruments for measuring skin toxicity Helen Taylor Summary References PART IV Clinical Aspects 13 Introduction to dermatology Manjunatha Kalavala and Alex Anstey Summary 14 Clinical aspects of phototoxicity Anthony D. Pearse and Alex Anstey Summary References 15 Occupational skin diseases Jon Spiro Summary References 16 Prevention of occupational skin disease Chris Packham Summary References PART V Regulatory 17 Occupational skin exposures: legal aspects Chris Packham Summary References 18 Safety assessment of cosmetics: an EU perspective Jo Larner Summary References Appendix 18.1 Additional obligations for cosmetic suppliers 19 Regulatory dermatotoxicology and international guidelines Adam Woolley Summary References 20 Glossary of main terms and abbreviations James C. Wakefield Index
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