Pharmaceutical Emulsions

A Drug Developer's Toolbag
Herausgegeben von Sarker, Dipak Kumar

• Gebundenes Buch

Produktbeschreibung

Pharmaceutical Emulsions: A Drug Developer's Toolbag covers all the key aspects of pharmaceutical emulsions, starting from the fundamental scientific basics, to the pharmaceutical forms and the chemical tests for its application. The author uses his extensive experience in both industry and academic experience to provide a concise, student friendly guide to the essential fundamentals of physical pharmacy.

Divided into three clear sections, the text begins with Section A - Consideration for Product: Medicinal Formulation which includes a historical perspective, explanation of what is an emulsion, stability and instability, and manufacture. Section B - Forms, Use and Application follows, with chapters on creams and ointments, pastes and bases, colloids, transdermal, gels and implants. The final Section, Tests: Chemistry to control the quality, efficacy and fitness for purpose of the product includes chapters on physic-chemical properties, sizing and microscopy, rheology, QC and finally questions, calculations and dilemmas. Throughout the text there are numerous figures, diagrams and tables to engage the reader.

This is an invaluable reference for all students of pharmaceutical sciences, pharmacy industrial pharmaceutical sciences, physical pharmacy and pharmaceutical forms as well as industry professionals

Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 206
• Erscheinungstermin: 14. Oktober 2013
• Englisch
• Abmessung: 251mm x 170mm x 15mm
• Gewicht: 480g
• ISBN-13: 9780470976838
• ISBN-10: 0470976837
• Artikelnr.: 39700374

Autorenporträt

Dipak K. Sarker School of Pharmacy and Biomolecular Sciences, University of Brighton, UK

Inhaltsangabe

Mathematical symbols (with normal units) xi Acronyms and abbreviations xiii
Preface xv Acknowledgements xvii About the companion website xix I Product
considerations: medicinal formulations 1 1 Historical perspective 5 1.1
Landmarks 5 1.2 Significant discoveries 7 1.3 Difficulties 8 1.4
Traditional uses 10 1.5 Product regulation 13 2 What is an emulsion? 15 2.1
States of matter 24 2.2 Summary thermodynamics 34 2.3 Interfacial tension
and wetting 36 2.4 Shear and size reduction 46 2.5 Raw materials 47 3
Stability, metastability and instability 49 3.1 Stokes' law 51 3.2
Derjaguin-Landau-Verwey-Overbeek (DLVO) theory 52 3.3 Interfacial rheology
56 4 Manufacture 63 4.1 Premixing 63 4.2 High-shear mixers and size
reduction 64 4.3 Multiple and microemulsions 65 4.4 Hot melt (steriles) 65
4.5 Filling 66 II Forms, uses and applications: biopharmaceutics 67 5
Creams and ointments 69 5.1 Nutraceuticals and cosmeceuticals 71 5.2
Medicinals 71 6 Pastes and bases 77 6.1 Emolliency 77 6.2 Suppositories 78
6.3 Pessaries 79 7 IV colloids 81 7.1 Needle free 86 7.2 Ocular therapy 87
7.3 Cancer 88 7.4 Antimicrobials 90 7.5 Temperature-sensitive matrices and
release forms 93 7.6 Targeted endosomal use 94 7.7 Solid lipid
nanoparticles 95 7.8 Diagnostic emulsions 98 8 Transdermal patches:
semisolids 99 8.1 Hormones 104 8.2 Analgesia 104 8.3 Anaesthesia 104 8.4
Nicotine 105 8.5 Inserts: vaginal rings 105 9 Gels 107 9.1 Micro- and
nanogels 107 9.2 Semisolids 107 10 Implants 109 10.1 Plastics and glasses
109 10.2 Thermoresponsive materials 110 11 De novo science, sustainable
novel products and platform applications 111 11.1 Tablets 113 11.2
Metered-dose inhalers 113 11.3 Blood substitutes 114 III Tests: chemistry
to control the quality, efficacy and fitness for purpose of a product 117
12 Physicochemical properties 119 12.1 Thermal evaluation (differential
scanning calorimetry) and lipid polymorphs 124 12.2 Drug form, log P and
Lipinski rules 129 12.3 Skin and epithelial models 133 12.4 Drug delivery
routes 134 13 Sizing and microscopy 137 13.1 zeta -potential 137 13.2
Hydrodynamic diameter 139 14 Rheology, texture, consistency and
spreadability 141 14.1 Bulk properties 141 14.2 Solid-state and
nanorheological properties 144 14.3 Interfacial properties 144 15 Quality
control, process analytical technology and accelerated testing 149 15.1
Preformulation, high-throughput screening 150 15.2 Industrial concerns 151
15.3 Rancimat and other methods 152 Questions 155 Guide for readers 155
Specimen 'test' questions 155 Answers 168 References 173 Index 181