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With the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews the mechanisms and functional consequences of mitochondrial fission and fusion. Further chapters address mitochondria and oxidative stress and their roles in cell signalling and cell death. The book includes extensive, fascinating discussion of the biochemistry of mitochondrial cell signalling…mehr
With the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews the mechanisms and functional consequences of mitochondrial fission and fusion. Further chapters address mitochondria and oxidative stress and their roles in cell signalling and cell death. The book includes extensive, fascinating discussion of the biochemistry of mitochondrial cell signalling (especially involving calcium) and of oxidative stress. The nature of the proteins engaged in these processes, many only recently discovered, is covered in detail. Mitochondria have been strongly implicated in neurodegenerative diseases such as Parkinson's, Huntington's and amyotrophic lateral sclerosis. They are also affected in cancer, ageing and cardiovascular disease. The final section of the book reviews mitochondrial mutations and their consequences in ageing and other phenotypic manifestations. The authors discuss how mitochondrial proteins might constitute important therapeutic targets and describe initial attempts to develop compounds that can regulate their function.
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The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research. Chairman: David G Nicholls, Buck Institute for Age Research, Novato, USA.
Inhaltsangabe
David G. Nicholls Chair's introduction Albert Neutzner, Richard J. Youle and Mariusz Karbowski Outer mitochondrial membrane protein degradation by the proteasome Discussion Sarah E. Haigh, Gilad Twig, Anthony A. J. Molina, Jakob D. Wikstrom, Motti Deutsch and Orian S. Shirihai PA-GFP: a window into the subcellular adventures of the individual mitochondrion Discussion Luca Scorrano Multiple functions of mitochondria-shaping proteins Discussion Bruce M. Spiegelman Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators Discussion Charles Affourtit, Paul G. Crichton, Nadeene Parker and Martin D. Brand Novel uncoupling proteins Discussion Cecilia Giulivi Mitochondria as generators and targets of nitric oxide Discussion György Hajnóczky, Masao Saotome, György Csordás, David Weaver and Muqing Yi Calcium signalling and mitochondrial motility Discussion Anna Romagnoli, Paola Aguiari, Diego De Stefani, Sara Leo, Saverio Marchi, Alessandro Rimessi, Erika Zecchini, Paolo Pinton and Rosario Rizzuto Endoplasmic reticulum/mitochondria calcium cross-talk Discussion Brian O'Rourke, Sonia Cortassa, Fadi Akar and Miguel Aon Mitochondrial ion channels in cardiac function and dysfunction Discussion Paolo Bernardi and Michael Forte The mitochondrial permeability transition pore Discussion Dominic James, Philippe A. Parone, Olivier Terradillos, Safa Lucken-Ardjomande, Sylvie Montessuit and Jean-Claude Martinou Mechanisms of mitochondrial outer membrane permeabilization Discussion M. Flint Beal Mitochondria and neurodegeneration Discussion Mügen Terzioglu and Nils-Göran Larsson Mitochondrial dysfunction in mammalian ageing Discussion Eric A. Schon and Salvatore DiMauro Mitochondrial mutations: genotype to phenotype Discussion Contributor Index Subject index
David G. Nicholls Chair's introduction Albert Neutzner, Richard J. Youle and Mariusz Karbowski Outer mitochondrial membrane protein degradation by the proteasome Discussion Sarah E. Haigh, Gilad Twig, Anthony A. J. Molina, Jakob D. Wikstrom, Motti Deutsch and Orian S. Shirihai PA-GFP: a window into the subcellular adventures of the individual mitochondrion Discussion Luca Scorrano Multiple functions of mitochondria-shaping proteins Discussion Bruce M. Spiegelman Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators Discussion Charles Affourtit, Paul G. Crichton, Nadeene Parker and Martin D. Brand Novel uncoupling proteins Discussion Cecilia Giulivi Mitochondria as generators and targets of nitric oxide Discussion György Hajnóczky, Masao Saotome, György Csordás, David Weaver and Muqing Yi Calcium signalling and mitochondrial motility Discussion Anna Romagnoli, Paola Aguiari, Diego De Stefani, Sara Leo, Saverio Marchi, Alessandro Rimessi, Erika Zecchini, Paolo Pinton and Rosario Rizzuto Endoplasmic reticulum/mitochondria calcium cross-talk Discussion Brian O'Rourke, Sonia Cortassa, Fadi Akar and Miguel Aon Mitochondrial ion channels in cardiac function and dysfunction Discussion Paolo Bernardi and Michael Forte The mitochondrial permeability transition pore Discussion Dominic James, Philippe A. Parone, Olivier Terradillos, Safa Lucken-Ardjomande, Sylvie Montessuit and Jean-Claude Martinou Mechanisms of mitochondrial outer membrane permeabilization Discussion M. Flint Beal Mitochondria and neurodegeneration Discussion Mügen Terzioglu and Nils-Göran Larsson Mitochondrial dysfunction in mammalian ageing Discussion Eric A. Schon and Salvatore DiMauro Mitochondrial mutations: genotype to phenotype Discussion Contributor Index Subject index
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