Acetaldehyde-Related Pathology (eBook, PDF)

Bridging the Trans-Disciplinary Divide
Redaktion: Chadwick, Derek J.; Goode, Jamie A.

• Format: PDF

Produktbeschreibung

Part of the prestigious Novartis Foundation, this is the first book to review the pathology associated with acetaldehyde, a known toxic agent found in cigarette smoke and other pollutants and derived from ingested alcohol, amongst other sources. In the body, acetaldehyde affects several tissues, particularly the brain and liver, causing various diseases, including cancer, alcoholic liver disease and Alzheimer's. Acetaldehyde-Related Pathology describes the toxic effects of acetaldehyde at the tissue and cellular levels, reviewing enzyme biochemistry, transgenic mouse models of alcohol dehydrogenase mutants, and the cell-signalling pathways implicated in alcohol-related pathology. It explores the mechanisms of acetaldehyde-induced damage to tissues, often a first step in carcinogenesis, including the oral cavity, the human airway, and the GI tract. The book considers pharmacological strategies and treatments for reducing oral and intestinal acetaldehyde. Acetaldehyde-Related Pathology features in-depth, round-table discussions by an international array of scientists from major laboratories worldwide involved in studies of acetaldehyde-related pathology. This book is essential reading for anyone interested in the effects of this compound - pathologists, biochemists, toxicologists, cell and molecular biologists.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 286
• Erscheinungstermin: 30. April 2007
• Englisch
• ISBN-13: 9780470511831
• Artikelnr.: 37295166

Autorenporträt

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research. Chairman: Peter Emery

Inhaltsangabe

Symposium on Acetaldehyde-related pathology: bridging the
trans-disciplinary divide, held at the Novartis Foundation, London 5-7th
September. Editors: Derek J. Chadwick (Organizer) and Jamie Goode This
symposium is based on a proposal made by Victor Preedy, Peter Emery and
Mikko Salaspuro Peter Emery Chair's introduction. David W. Crabb and Suthat
Liangpunsakul Acetaldehyde generating enzyme systems: roles of alcohol
dehydrogenase, CYP2E1 and catalase, and speculations on the role of other
enzymes and processes. Discussion. Richard A. Deitrich, Dennis Petersen and
Vasilis Vasiliou Removal of acetaldehyde from the body. Discussion.
Shih-Jiun Yin and Giia-Sheun Peng Acetaldehyde, polymorphisms and the
cardiovascular system. Discussion. Jun Ren Acetaldehyde and alcoholic
cardiomyopathy: lessons from the ADH and ALDH2 transgenic models.
Discussion. Mikko Salaspuro Interrelationship between alcohol, smoking,
acetaldehyde and cancer. Discussion. Hiroto Matsuse, Chizu Fukushima,
Terufumi Shimoda, Sadahiro Asai and Shigeru Kohno Effects of acetaldehyde
on human airway constriction and infl ammation. Discussion. Helmut K. Seitz
The role of acetaldehyde in alcohol-associated cancer of the
gastrointestinal tract. Discussion. Robert Tardif The determination of
acetaldehyde in exhaled breath. Discussion. Mostofa Jamal, Kiyoshi Ameno,
Mitsuru Kumihashi, Weihuan Wang, Ikuo Uekita and Iwao Ijiri Ethanol and
acetaldehyde: in vivo quantitation and effects on cholinergic function in
rat brain. Discussion. Ville Salaspuro Pharmacological treatments and
strategies for reducing oral and intestinal acetaldehyde. Discussion.
Victor R. Preedy, David W. Crabb, Jaume Farrés and Peter W. Emery Alcoholic
myopathy and acetaldehyde. Discussion. Onni Niemelä Acetaldehyde adducts in
circulation. Discussion. General discussion. M. Apte, J. McCarroll, R.
Pirola and J. Wilson Pancreatic MAP kinase pathways and acetaldehyde.
Discussion. Shivendra D. Shukla, Youn Ju Lee, Pil-hoon Park and Annayya R.
Aroor Acetaldehyde alters MAP kinase signalling and epigenetic histone
modifi cations in hepatocytes. Discussion. Paul J. Thornalley Endogenous
alpha-oxoaldehydes and formation of protein and nucleotide advanced
glycation endproducts in tissue damage. Discussion. C. J. Peter Eriksson
Measurement of acetaldehyde: what levels occur naturally and in response to
alcohol? Discussion. Final discussion. Contributors Index. Subject Index.

Rezensionen

" will be found on the shelves of most scientific biomedical libraries." ( Doody s Book Reviews )