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Part of the prestigious Novartis Foundation, this is the first book to review the pathology associated with acetaldehyde, a known toxic agent found in cigarette smoke and other pollutants and derived from ingested alcohol, amongst other sources. In the body, acetaldehyde affects several tissues, particularly the brain and liver, causing various diseases, including cancer, alcoholic liver disease and Alzheimer's. Acetaldehyde-Related Pathology describes the toxic effects of acetaldehyde at the tissue and cellular levels, reviewing enzyme biochemistry, transgenic mouse models of alcohol…mehr
Part of the prestigious Novartis Foundation, this is the first book to review the pathology associated with acetaldehyde, a known toxic agent found in cigarette smoke and other pollutants and derived from ingested alcohol, amongst other sources. In the body, acetaldehyde affects several tissues, particularly the brain and liver, causing various diseases, including cancer, alcoholic liver disease and Alzheimer's. Acetaldehyde-Related Pathology describes the toxic effects of acetaldehyde at the tissue and cellular levels, reviewing enzyme biochemistry, transgenic mouse models of alcohol dehydrogenase mutants, and the cell-signalling pathways implicated in alcohol-related pathology. It explores the mechanisms of acetaldehyde-induced damage to tissues, often a first step in carcinogenesis, including the oral cavity, the human airway, and the GI tract. The book considers pharmacological strategies and treatments for reducing oral and intestinal acetaldehyde. Acetaldehyde-Related Pathology features in-depth, round-table discussions by an international array of scientists from major laboratories worldwide involved in studies of acetaldehyde-related pathology. This book is essential reading for anyone interested in the effects of this compound - pathologists, biochemists, toxicologists, cell and molecular biologists.
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research. Chairman: Peter Emery
Inhaltsangabe
Symposium on Acetaldehyde-related pathology: bridging the trans-disciplinary divide, held at the Novartis Foundation, London 5-7th September 2006 Editors: Derek J. Chadwick (Organizer) and Jamie Goode This symposium is based on a proposal made by Victor Preedy, Peter Emery and Mikko Salaspuro Peter Emery Chair's introduction 1 David W. Crabb and Suthat Liangpunsakul Acetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes 4 Discussion 16 Richard A. Deitrich, Dennis Petersen and Vasilis Vasiliou Removal of acetaldehyde from the body 23 Discussion 40 Shih-Jiun Yin and Giia-Sheun Peng Acetaldehyde, polymorphisms and the cardiovascular system 52 Discussion 63 Jun Ren Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models 69 Discussion 76 Mikko Salaspuro Interrelationship between alcohol, smoking, acetaldehyde and cancer 80 Discussion 89 Hiroto Matsuse, Chizu Fukushima, Terufumi Shimoda, Sadahiro Asai and Shigeru Kohno Effects of acetaldehyde on human airway constriction and inflammation 97 Discussion 106 Helmut K. Seitz The role of acetaldehyde in alcohol-associated cancer of the gastrointestinal tract 110 Discussion 119 Robert Tardif The determination of acetaldehyde in exhaled breath 125 Discussion 133 Mostofa Jamal, Kiyoshi Ameno, Mitsuru Kumihashi, Weihuan Wang, Ikuo Uekita and Iwao Ijiri Ethanol and acetaldehyde: in vivo quantitation and effects on cholinergic function in rat brain 137 Discussion 141 Ville Salaspuro Pharmacological treatments and strategies for reducing oral and intestinal acetaldehyde 145 Discussion 153 Victor R. Preedy, David W. Crabb, Jaume Farrés and Peter W. Emery Alcoholic myopathy and acetaldehyde 158 Discussion 177 Onni Niemelä Acetaldehyde adducts in circulation 183 Discussion 193 General discussion 198 M. Apte, J. McCarroll, R. Pirola and J. Wilson Pancreatic MAP kinase pathways and acetaldehyde 200 Discussion 211 Shivendra D. Shukla, Youn Ju Lee, Pil-hoon Park and Annayya R. Aroor Acetaldehyde alters MAP kinase signalling and epigenetic histone modifications in hepatocytes 217 Discussion 224 Paul J. Thornalley Endogenous ?'-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damage 229 Discussion 243 C. J. Peter Eriksson Measurement of acetaldehyde: what levels occur naturally and in response to alcohol? 247 Discussion 256 Final discussion 261 Contributors Index 265 Subject index 267
Symposium on Acetaldehyde-related pathology: bridging the trans-disciplinary divide, held at the Novartis Foundation, London 5-7th September. Editors: Derek J. Chadwick (Organizer) and Jamie Goode This symposium is based on a proposal made by Victor Preedy, Peter Emery and Mikko Salaspuro Peter Emery Chair's introduction. David W. Crabb and Suthat Liangpunsakul Acetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes. Discussion. Richard A. Deitrich, Dennis Petersen and Vasilis Vasiliou Removal of acetaldehyde from the body. Discussion. Shih-Jiun Yin and Giia-Sheun Peng Acetaldehyde, polymorphisms and the cardiovascular system. Discussion. Jun Ren Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. Discussion. Mikko Salaspuro Interrelationship between alcohol, smoking, acetaldehyde and cancer. Discussion. Hiroto Matsuse, Chizu Fukushima, Terufumi Shimoda, Sadahiro Asai and Shigeru Kohno Effects of acetaldehyde on human airway constriction and infl ammation. Discussion. Helmut K. Seitz The role of acetaldehyde in alcohol-associated cancer of the gastrointestinal tract. Discussion. Robert Tardif The determination of acetaldehyde in exhaled breath. Discussion. Mostofa Jamal, Kiyoshi Ameno, Mitsuru Kumihashi, Weihuan Wang, Ikuo Uekita and Iwao Ijiri Ethanol and acetaldehyde: in vivo quantitation and effects on cholinergic function in rat brain. Discussion. Ville Salaspuro Pharmacological treatments and strategies for reducing oral and intestinal acetaldehyde. Discussion. Victor R. Preedy, David W. Crabb, Jaume Farrés and Peter W. Emery Alcoholic myopathy and acetaldehyde. Discussion. Onni Niemelä Acetaldehyde adducts in circulation. Discussion. General discussion. M. Apte, J. McCarroll, R. Pirola and J. Wilson Pancreatic MAP kinase pathways and acetaldehyde. Discussion. Shivendra D. Shukla, Youn Ju Lee, Pil-hoon Park and Annayya R. Aroor Acetaldehyde alters MAP kinase signalling and epigenetic histone modifi cations in hepatocytes. Discussion. Paul J. Thornalley Endogenous alpha-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damage. Discussion. C. J. Peter Eriksson Measurement of acetaldehyde: what levels occur naturally and in response to alcohol? Discussion. Final discussion. Contributors Index. Subject Index.
Symposium on Acetaldehyde-related pathology: bridging the trans-disciplinary divide, held at the Novartis Foundation, London 5-7th September 2006 Editors: Derek J. Chadwick (Organizer) and Jamie Goode This symposium is based on a proposal made by Victor Preedy, Peter Emery and Mikko Salaspuro Peter Emery Chair's introduction 1 David W. Crabb and Suthat Liangpunsakul Acetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes 4 Discussion 16 Richard A. Deitrich, Dennis Petersen and Vasilis Vasiliou Removal of acetaldehyde from the body 23 Discussion 40 Shih-Jiun Yin and Giia-Sheun Peng Acetaldehyde, polymorphisms and the cardiovascular system 52 Discussion 63 Jun Ren Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models 69 Discussion 76 Mikko Salaspuro Interrelationship between alcohol, smoking, acetaldehyde and cancer 80 Discussion 89 Hiroto Matsuse, Chizu Fukushima, Terufumi Shimoda, Sadahiro Asai and Shigeru Kohno Effects of acetaldehyde on human airway constriction and inflammation 97 Discussion 106 Helmut K. Seitz The role of acetaldehyde in alcohol-associated cancer of the gastrointestinal tract 110 Discussion 119 Robert Tardif The determination of acetaldehyde in exhaled breath 125 Discussion 133 Mostofa Jamal, Kiyoshi Ameno, Mitsuru Kumihashi, Weihuan Wang, Ikuo Uekita and Iwao Ijiri Ethanol and acetaldehyde: in vivo quantitation and effects on cholinergic function in rat brain 137 Discussion 141 Ville Salaspuro Pharmacological treatments and strategies for reducing oral and intestinal acetaldehyde 145 Discussion 153 Victor R. Preedy, David W. Crabb, Jaume Farrés and Peter W. Emery Alcoholic myopathy and acetaldehyde 158 Discussion 177 Onni Niemelä Acetaldehyde adducts in circulation 183 Discussion 193 General discussion 198 M. Apte, J. McCarroll, R. Pirola and J. Wilson Pancreatic MAP kinase pathways and acetaldehyde 200 Discussion 211 Shivendra D. Shukla, Youn Ju Lee, Pil-hoon Park and Annayya R. Aroor Acetaldehyde alters MAP kinase signalling and epigenetic histone modifications in hepatocytes 217 Discussion 224 Paul J. Thornalley Endogenous ?'-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damage 229 Discussion 243 C. J. Peter Eriksson Measurement of acetaldehyde: what levels occur naturally and in response to alcohol? 247 Discussion 256 Final discussion 261 Contributors Index 265 Subject index 267
Symposium on Acetaldehyde-related pathology: bridging the trans-disciplinary divide, held at the Novartis Foundation, London 5-7th September. Editors: Derek J. Chadwick (Organizer) and Jamie Goode This symposium is based on a proposal made by Victor Preedy, Peter Emery and Mikko Salaspuro Peter Emery Chair's introduction. David W. Crabb and Suthat Liangpunsakul Acetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes. Discussion. Richard A. Deitrich, Dennis Petersen and Vasilis Vasiliou Removal of acetaldehyde from the body. Discussion. Shih-Jiun Yin and Giia-Sheun Peng Acetaldehyde, polymorphisms and the cardiovascular system. Discussion. Jun Ren Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. Discussion. Mikko Salaspuro Interrelationship between alcohol, smoking, acetaldehyde and cancer. Discussion. Hiroto Matsuse, Chizu Fukushima, Terufumi Shimoda, Sadahiro Asai and Shigeru Kohno Effects of acetaldehyde on human airway constriction and infl ammation. Discussion. Helmut K. Seitz The role of acetaldehyde in alcohol-associated cancer of the gastrointestinal tract. Discussion. Robert Tardif The determination of acetaldehyde in exhaled breath. Discussion. Mostofa Jamal, Kiyoshi Ameno, Mitsuru Kumihashi, Weihuan Wang, Ikuo Uekita and Iwao Ijiri Ethanol and acetaldehyde: in vivo quantitation and effects on cholinergic function in rat brain. Discussion. Ville Salaspuro Pharmacological treatments and strategies for reducing oral and intestinal acetaldehyde. Discussion. Victor R. Preedy, David W. Crabb, Jaume Farrés and Peter W. Emery Alcoholic myopathy and acetaldehyde. Discussion. Onni Niemelä Acetaldehyde adducts in circulation. Discussion. General discussion. M. Apte, J. McCarroll, R. Pirola and J. Wilson Pancreatic MAP kinase pathways and acetaldehyde. Discussion. Shivendra D. Shukla, Youn Ju Lee, Pil-hoon Park and Annayya R. Aroor Acetaldehyde alters MAP kinase signalling and epigenetic histone modifi cations in hepatocytes. Discussion. Paul J. Thornalley Endogenous alpha-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damage. Discussion. C. J. Peter Eriksson Measurement of acetaldehyde: what levels occur naturally and in response to alcohol? Discussion. Final discussion. Contributors Index. Subject Index.
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