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The premier reference on the cutting-edge technology driving new drug development
Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. LC/MS is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs. This book is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufacturing phases.
In addition to the thorough technical analysis of this tool, LC/MS Applications in Drug Development provides perspective on the significant changes in strategies for pharmaceutical analysis. A process overview of drug development from an analytical point of view is provided along with essential data required to successfully bring a drug to market. The incorporation of LC/MS is illustrated from target to product. Chapters pertaining to the discovery process itself include:
_ Proteomics
_ Glycoprotein Mapping
_ Natural Products Dereplication
_ Lead Identification Screening
_ Open-Access LC/MS
_ In Vivo Drug Screening
_ In Vitro Drug Screening
Written for both the analytical chemist who uses LC/MS applications and the pharmaceutical scientist who works with the drugs they produce, LC/MS Applications in Drug Development is the premier reference on the subject.
Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. LC/MS is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs. This book is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufacturing phases.
In addition to the thorough technical analysis of this tool, LC/MS Applications in Drug Development provides perspective on the significant changes in strategies for pharmaceutical analysis. A process overview of drug development from an analytical point of view is provided along with essential data required to successfully bring a drug to market. The incorporation of LC/MS is illustrated from target to product. Chapters pertaining to the discovery process itself include:
_ Proteomics
_ Glycoprotein Mapping
_ Natural Products Dereplication
_ Lead Identification Screening
_ Open-Access LC/MS
_ In Vivo Drug Screening
_ In Vitro Drug Screening
Written for both the analytical chemist who uses LC/MS applications and the pharmaceutical scientist who works with the drugs they produce, LC/MS Applications in Drug Development is the premier reference on the subject.
"...a comprehensive primer and will appeal to laboratory scientists and instructors in the pharmaceutical field..." ( Analytical Chemistry , November 2002)
"...describes...applications in each phase of drug development...provides perspective on changes in strategies for pharmaceutical analysis..." ( SciTech Book News , Vol. 26, No. 2, June 2002)
"...describes...applications in each phase of drug development...provides perspective on changes in strategies for pharmaceutical analysis..." ( SciTech Book News , Vol. 26, No. 2, June 2002)