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  • Gebundenes Buch

Discover how advances in mass spectrometry are fueling new discoveries across a broad range of research areas Electrospray and MALDI Mass Spectrometry brings both veteran practitioners and beginning scientists up to date with the most recent trends and findings in electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. In particular, this Second Edition highlights how advances in electrospray and MALDI mass spectrometry are supporting important discoveries in new and emerging fields such as proteomics and metabolomics as well as in traditional areas…mehr

Produktbeschreibung
Discover how advances in mass spectrometry are fueling new discoveries across a broad range of research areas Electrospray and MALDI Mass Spectrometry brings both veteran practitioners and beginning scientists up to date with the most recent trends and findings in electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. In particular, this Second Edition highlights how advances in electrospray and MALDI mass spectrometry are supporting important discoveries in new and emerging fields such as proteomics and metabolomics as well as in traditional areas of chemistry and physics research. Electrospray AND MALDI Mass Spectrometry, SECOND EDITION is divided into five parts: * Part A, Fundamentals of ES, explains the fundamental phenomena underlying the electrospray process, including selectivity in ionization and inherent electrochemistry, and concludes with a chapter offering a comparative inventory of source hardware * Part B, Fundamentals of MALDI, confronts ionization mechanisms, instrument development, and matrix selection, and includes a final chapter that explores the special application of MALDI to obtain two-dimensional images of spatial distributions of compounds on surfaces * Part C, ES and MALDI Coupling to Mass Spectrometry Instrumentation, examines the coupling of these ionization techniques to various mass analyzers, including quadrupole ion trap, time-of-flight, Fourier transform ion cyclotron resonance, and ion mobility mass spectrometers * Part D, Practical Aspects of ES and MALDI, investigates analytical issues including quantification, charge-state distributions, noncovalent interactions in solution that are preserved as gas-phase ions, and various means of ion excitation in preparation for tandem mass spectrometry, and offers a guide to the interpretation of even-electron mass spectra * Part E, Biological Applications of ES and MALDI, examines the role of mass spectrometry in such areas as peptide and protein characterization, carbohydrate analysis, lipid analysis, and drug discovery Written by a team of leading experts, the book not only provides a critical review of the literature, but also presents key concepts in tutorial fashion to help readers take full advantage of the latest technological breakthroughs and applications. As a result, Electrospray and MALDI Mass Spectrometry will help researchers fully leverage the power of electrospray and MALDI mass spectrometry. The judicious compartmentalization of chapters, and the pedagogic presentation style throughout, render the book highly suitable for use as a text for graduate-level courses in advanced mass spectrometry.
  • Produktdetails
  • Verlag: John Wiley & Sons / WILEY
  • Artikelnr. des Verlages: 14674107000
  • 2. Auflage
  • Seitenzahl: 896
  • Erscheinungstermin: April 2010
  • Englisch
  • Abmessung: 264mm x 181mm x 55mm
  • Gewicht: 1819g
  • ISBN-13: 9780471741077
  • ISBN-10: 0471741078
  • Artikelnr.: 26160878
Autorenporträt
RICHARD B. COLE, PHD, is a University Research Professor in The Department of Chemistry at The University of New Orleans. He has spent more than twenty-five years working in the field of mass spectrometry. His research interests include analytical/bio-organic chemistry as well as fundamentals and applications of mass spectrometry, with a focus on the development of novel analytical methods employing electrospray and MALDI.
Inhaltsangabe
Foreword: Desorption Ionization and Spray Ionization: Connections and Progress (R. Graham Cooks). Foreword to the First Edition (John B. Fenn). Preface (Richard B. Cole). Contributors. Part I Fundamentals of ES. 1. On the Mechanism of Electrospray Ionization Mass Spectrometry (ESIMS) (Paul Kebarle and Udo H. Verkerk). 2. Selectivity in Electrospray Ionization Mass Spectrometry (Nadja B. Cech and Christie G. Enke). 3. Electrochemistry of the Electrospray Ion Source (Gary J. Van Berkel and Vilmos Kertesz). 4. ESI Source Design (Andries P. Bruins). Part II Fundamentals of MALDI. 5. MALDI Ionization Mechanisms: an Overview (Richard Knochenmuss). 6. The Development of Matrix-Assisted Laser Desorption/Ionization Sources (Peter B. O'Connor). 7. A Comparison of MALDI Matrices (Mahmud Hossain and Patrick A. Limbach). 8. MALDI Imaging Mass Spectrometry (Alain Brunelle and Olivier Laprevote). Part III ES and MALDI Coupling to Mass Spectrometry Instrumentation. 9. Coupling ESI and MALDI Sources to the Quadrupole Mass Filter
Quadrupole Ion Trap
Linear Quadrupole Ion Trap
and Orbitrap Mass Analyzers (Mark E. Bier). 10. Time-of-Flight Mass Spectrometry (Robert J. Cotter). 11. Fourier Transform Ion Cyclotron Resonance and Magnetic Sector Analyzers for ESI and MALDI (Jeremy J. Wolff and I. Jonathan Amster). 12. Ion Mobility-Mass Spectrometry (John A. McLean
J. Albert Schultz
and Amina S. Woods). Part IV Practical Aspects of ES and MALDI. 13. ESI
APCI
and MALDI A Comparison of the Central Analytical Figures of Merit: Sensitivity
Reproducibility
and Speed (Thomas R. Covey
Bradley B. Schneider
Hassan Javaheri
J.C. Yves LeBlanc
Gordana Ivosev
Jay J. Corr
and Peter Kovarik). 14. Charge State Distributions in Electrospray and MALDI (Yan Li and Richard B. Cole). 15. Probing Noncovalent Interactions by Electrospray Ionization and Matrix-Assisted Laser Desorption/Ionization (Sonal Mathur
Alexis Nazabal
and Renato Zenobi). 16. Ion Activation Methods for Tandem Mass Spectrometry (Kristina Hakansson and John S. Klassen). 17. Dissociation of Even-Electron Ions (Carlos Afonso
Richard B. Cole
and Jean-Claude Tabet). Part V Biological Applications of ES and MALDI. 18. The Role of Mass Spectrometry for Peptide
Protein
and Proteome Characterization (A. Jimmy Ytterberg
Jason Dunsmore
Shirley H. Lomeli
Mario Thevis
Yongming Xie
Rachel R. Ogorzalek Loo
and Joseph A. Loo). 19. Carbohydrate Analysis by ESI and MALDI (David J. Harvey). 20. Applications of ESI and MALDI to Lipid Analysis (Xianlin Han). 21. In Vitro ADME Profiling and Pharmacokinetic Screening in Drug Discovery (Daniel B. Kassel). Index.