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"This excellent work fills the need for an upper-levelgraduate course resource that examines the latest biochemical,biophysical, and molecular biological methods for analyzing thestructures and physical properties of biomolecules... Thisreviewer showed [the book] to several of his senior graduatestudents, and they unanimously gave the book rave reviews.Summing Up: Highly recommended..." CHOICE Chemical biology is a rapidly developing branch of chemistry,which sets out to understand the way biology works at the molecularlevel. Fundamental to chemical biology is a detailed understandingof the…mehr

Produktbeschreibung
"This excellent work fills the need for an upper-levelgraduate course resource that examines the latest biochemical,biophysical, and molecular biological methods for analyzing thestructures and physical properties of biomolecules... Thisreviewer showed [the book] to several of his senior graduatestudents, and they unanimously gave the book rave reviews.Summing Up: Highly recommended..." CHOICE Chemical biology is a rapidly developing branch of chemistry,which sets out to understand the way biology works at the molecularlevel. Fundamental to chemical biology is a detailed understandingof the syntheses, structures and behaviours of biologicalmacromolecules and macromolecular lipid assemblies that togetherrepresent the primary constituents of all cells and all organisms.The subject area of chemical biology bridges many differentdisciplines and is fast becoming an integral part of academic andcommercial research. This textbook is designed specifically as a key teachingresource for chemical biology that is intended to build onfoundations lain down by introductory physical and organicchemistry courses. This book is an invaluable text for advancedundergraduates taking biological, bioorganic, organic andstructural chemistry courses. It is also of interest to biochemistsand molecular biologists, as well as professionals within themedical and pharmaceutical industry. Key Features: * A comprehensive introduction to this dynamic area of chemistry,which will equip chemists for the task of understanding andstudying the underlying principles behind the functioning ofbiological macro molecules, macromolecular lipid assemblies andcells. * Covers many basic concepts and ideas associated with the studyof the interface between chemistry and biology. * Includes pedagogical features such as: key examples, glossaryof equations, further reading and links to websites. * Clearly written and richly illustrated in fullcolour.
  • Produktdetails
  • Verlag: John Wiley & Sons
  • Seitenzahl: 590
  • Erscheinungstermin: 14.09.2008
  • Englisch
  • ISBN-13: 9780470987155
  • Artikelnr.: 37301368
Inhaltsangabe
Preface. Mapping the essentials of chemical biology. Glossary of physical terms. 1. The structures of biological macromolecules and lipid assemblies. 1.1 General introduction. 1.2 Protein structure. 1.3 Carbohydrate structure. 1.4 Nucleic acid structure. 1.5 Macromolecular lipid assemblies. 1.6 Structural forces in biological macromolecules. 2. Chemical and biological synthesis. 2.1 Introduction to synthesis in chemical biology. 2.2 Chemical synthesis of peptides and proteins. 2.3 Chemical synthesis of nucleic acids. 2.4 Chemical synthesis of oligosaccharides. 2.5 Chemical synthesis of lipids. 2.6 Biological synthesis of biological macromolecules. 2.7 Directed biological synthesis of proteins. 2.8 Biological syntheses of nucleic acids, oligosaccharides and lipids. 3. Molecular biology as a toolset for chemical biology. 3.1 Key concepts in molecular biology. 3.2 Tools and techniques in molecular biology. 3.3 Cloning and identification of genes in DNA. 3.4 Integrating cloning and expression. 3.5 Site
directed mutagenesis. 4. Electronic and vibrational spectroscopy. 4.1 Electronic and vibrational spectroscopy in chemical biology. 4.2 UV
visible spectroscopy. 4.3 Circular dichroism spectroscopy. 4.4 Vibrational spectroscopy. 4.5 Fluorescence spectroscopy. 4.6 Probing metal centres in biological systems by spectroscopy. 5. Magnetic resonance. 5.1 Magnetic resonance in chemical biology. 5.2 Key principles of NMR. 5.3 Two
dimensional NMR. 5.4 Multi
dimensional NMR. 5.5 Biological macromolecule structural information. 5.6 EPR spectroscopy; key principles. 6. Diffraction and microscopy. 6.1 Diffraction and microscopy in chemical biology. 6.2 Key principles of X
ray diffraction. 6.3 Structural information from X
ray diffraction. 6.4 Neutron diffraction. 6.5 Key principles of electron microscopy. 6.6 Key principles of scanning probe microscopy. 7. Molecular recognition and binding. 7.1 Molecular recognition and binding in chemical biology. 7.2 Theoretical models of binding. 7.3 Analysing molecular recognition and binding. 7.4 Biological molecular recognition studies. 8. Kinetics and catalysis. 8.1 Catalysis in chemical biology. 8.2 Steady state kinetic schemes. 8.3 Pre
steady
state kinetics. 8.4 Theories of biocatalysis. 8.5 Electron transfer. 9. Mass spectrometry and proteomics. 9.1 Mass spectrometry in chemical biology. 9.2 Key principles in mass spectrometry . 9.3 Structural analysis of biological macromolecules and lipids by mass spectrometry. 9.4 The challenge of proteomics. 9.5 Genomics
assigning function to genes and proteins. 10. Molecular selection and evolution. 10.1 Chemical biology and the origins of life. 10.2 Molecular breeding; natural selection acting on self
organisation. 10.3 Directed evolution of protein function. 10.4 Directed evolution of nucleic acids. 10.5 Catalytic antibodies.

Introduction: What is Biological Chemistry?
Chapter One: Basic Biomolecule Structures.
Chapter Two: Mass Spectrometry.
Chapter Three: Vibrational Spectroscopy.
Chapter Four: Electronic Spectroscopy.
Chapter Five: Magnetic Resonance.
Chapter Six: Diffraction and Microscopy.
Chapter Seven: Structural Forces and Thermodynamics.
Chapter Eight: Modelling Structure.
Chapter Nine: Kinetics.
Chapter Ten: Molecular Recognition.
Chapter Eleven:Molecular Motion.Chapter Twelve: Self Assembly of Biomolecules.
Rezensionen
"This excellent work fills the need for an upper-level graduate course resource that examines the latest biochemical, biophysical, and molecular biological methods for analyzing the structures and physical properties of biomolecules. Miller (Imperial College London, UK) and Tanner (Univ. of Hong Kong) cover traditional subjects such as binding interactions and catalysis. They also describe biophysical theories and current methods for protein structure determinations such as circular dichroism, X-ray crystallography, neutron diffraction, NMR, EPR, fluorescence, mass spectrometry, and electron and atomic force microscopy. For example, the chapter on solution NMR provides simplified yet high-quality explanations of the key principles of NMR. The well-developed introduction helps students to better follow the more complex information concerning the principles of multidimensional NMR. In addition, the latter part of the chapter offers current applications using a variety of multidimensional NMR spectroscopy experiments in the analysis of proteins, nucleic acid, carbohydrate, and lipid structures. This reviewer showed Essentials of Chemical Biology to several of his senior graduate students, and they unanimously gave the book rave reviews. The work could be improved by better referencing the resource materials within the text and by providing student exercises at the end of each chapter. Summing Up: Highly recommended. Collections serving graduate students, researchers/faculty, and professionals." -- J. M. Tomich, Kansas State University (Choice, February 2009)…mehr
"Essentials in Chemical Biology is a valuable resource not only for chemistry students who are venturing into and interested in biological systems, but also biochemistry and biology students who want a fundamental understanding of the physical and chemical basis of biology and the techniques used in its study." (Chemistry World, August 2009)

"The succinct and lucid presentation style of Essentials Of Chemical Biology will likely make it a popular resource for undergraduate and graduate students interested in the structure and interaction of biologically relevant macromolecules." (Journal of Chemical Biology, February 2009)

"This excellent work fills the need for an upper-level graduate course resource that examines the latest biochemical, biophysical, and molecular biological methods for analyzing the structures and physical properties of biomolecules. Miller (Imperial College London, UK) and Tanner (Univ. of Hong Kong) cover traditional subjects such as binding interactions and catalysis. They also describe biophysical theories and current methods for protein structure determinations such as circular dichroism, X-ray crystallography, neutron diffraction, NMR, EPR, fluorescence, mass spectrometry, and electron and atomic force microscopy. For example, the chapter on solution NMR provides simplified yet high-quality explanations of the key principles of NMR. The well-developed introduction helps students to better follow the more complex information concerning the principles of multidimensional NMR. In addition, the latter part of the chapter offers current applications using a variety of multidimensional NMR spectroscopy experiments in the analysis of proteins, nucleic acid, carbohydrate, and lipid structures. This reviewer showed Essentials of Chemical Biology to several of his senior graduate students, and they unanimously gave the book rave reviews. The work could be improved by better referencing the resource materials within the text and by providing student exercises at the end of each chapter." (J. M. Tomich, Kansas State University, Choice, February 2009)…mehr