Inflammation (eBook, ePUB)

From Molecular and Cellular Mechanisms to the Clinic
Redaktion: Cavaillon, Jean-Marc; Singer, Mervyn

• Format: ePub

Produktbeschreibung

Dieses Fachbuch erläutert die molekularen Grundlagen von Entzündungen, spannt den Bogen zu Infektionskrankheiten und den Zusammenhang zwischen Entzündungen und chronischen Erkrankungen, behandelt abschließend den Heilungsprozess und zeigt Therapiemöglichkeiten.

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Produktdetails

• Verlag: Wiley-VCH GmbH
• Seitenzahl: 1830
• Erscheinungstermin: 2. Oktober 2017
• Englisch
• ISBN-13: 9783527692163
• Artikelnr.: 52551455

Autorenporträt

Jean-Marc Cavaillon is professor and Head of the Unit "Cytokines and Inflammation" at Institut Pasteur (Paris). He has been President of the "International Endotoxin and Innate Immunity Society". He is member of the Editorial Boards of few journals including Shock, Journal of Infectious Diseases, and International Journal of Inflammation, and has been Associate-Editor of "Cytokine" (2002-2009). Jean-Marc Cavaillon has an extensive expertise in innate immunity, particularly on cytokines, inflammation, bacterial endotoxins and other Toll-like receptors agonists, endotoxin tolerance, activation of monocytes/macrophages and neutrophils, altered immune status in sepsis and SIRS patients. He is the co-author of a book "Sepsis and non-infectious inflammation: from biology to critical care" (Wiley VCH, 2009) and the author of a book in French on cytokines (Masson, 1993 & 1996) . Jean-Marc Cavaillon has published 145 scientific articles, 77 reviews and 45 chapters in books. Mervyn Singer is Professor of Intensive Care Medicine at University College London. His primary research interests are sepsis and multi-organ failure, infection, shock and haemodynamic monitoring. Funding for these activities primarily comes from the Wellcome Trust, Medical Research Council and National Institute for Health Research. He developed an oesophageal Doppler haemodynamic monitor that is now in widespread use worldwide, the use of which has been shown in multiple studies to improve outcomes after major surgery and reduce length of stay. He has led on a number of important multi-centre trials in critical care. He has authored various papers and textbooks including the Oxford Handbook of Critical Care, now in its 3rd Edition, and is a Council member of the International Sepsis Forum. He was the first UK intensivist to be awarded Senior Investigator status by the National Institute for Health Research, and to be invited to give plenary lectures at the European and US Intensive Care Congresses.

Inhaltsangabe

Inflammation through the Ages: A Historical PerspectivePART I: INDUCERS AND SENSORS OF INFLAMMATIONPathogen-associated Molecular PatternsDamage-associated Molecular PatternsBacterial ToxinsVenomsHypoxia as an Inducer of InflammationVaccine AdjuvantsPattern Recognition ReceptorsPART II: INFLAMMATORY CELLSMonocytes and MacrophagesNeutrophilsMast Cells: Master Drivers of Immune Responses against PathogensDendritic Cells in Inflammatory DiseaseRoles for NK Cells and ILC1 in Inflammation and Infection Group 2 and Group 3 Innate Lymphoid Cells: New Actors in Immunity and Inflammation Th9 Cells: From the Bench to the Bedside and Back AgainTh17 CellsPlateletsEpithelial CellsInflammation: The Role of Endothelial CellsPART III: INFLAMMATORY MEDIATORSIL-1 Superfamily and InflammasomeTNF Superfamily Interleukin-17 A-EIL-6 SuperfamilyType I and II Cytokine Superfamilies in Inflammatory ResponsesChemokines and ChemotaxisLipid Mediators in InflammationFree Radicals in InflammationProteasesPsychiatric Disorders and Inflammation Complement SystemHeat Shock ProteinsPART IV: INFLAMMATION AND HOST RESPONSEInflammation and Coagulation Fever: Mediators and MechanismsPainInflammation, Hormones and MetabolismMicroenvironmental Regulation of Innate Immune Cell FunctionEpigenetics of InflammationPART V: INFLAMMATION AND DISEASESAllergy and InflammationSepsisAutoimmunity and InflammationPsoriasis and Other Skin Inflammatory DiseasesRheumatoid Arthritis and Other Inflammatory Articular DiseasesMissing Heritability of Crohn's Disease and Implications for Therapeutic Targeting and Improved CareInflammation and TransplantationInflammatory Mechanisms in Chronic Obstructive Pulmonary DiseaseObesity: A Complex Disease with Immune ComponentsInflammation and Type 2 DiabetesInflammation-Mediated Neurodegeneration: Models, Mechanisms, and Therapeutic Interventions for Neurodegenerative DiseasesInflammation in AtherosclerosisAcute Kidney InjuryIschemia-Reperfusion SyndromeSingle Nucleotide Polymorphisms and InflammationPART VI: RESOLUTION OF INFLAMMATION AND TISSUE REPAIRPentraxins in the Orchestration of Defence and Tissue Repair During the Acute Phase ResponseAnti-inflammatory Cytokines, Soluble Receptors, and Natural AntagonistsRegulatory T CellsLeukocyte ReprogrammingRoles of Specialized Proresolving Lipid Mediators in Inflammation-Resolution and Tissue RepairGlucocorticoidsThe Neuroimmune Communicatome in InflammationThe Inflammatory Response in Tissue RepairPART VII: DETECTION AND TREATMENTSBiomarkers in InflammationIn Vivo Imaging of InflammationNovel Targets for Drug DevelopmentInflammation, Microbiota and Gut ReconditioningNatural Products as Source of Anti-Inflammatory Drugs