TNF-alpha plays a crucial role in the pathogenesis of many chronic inflammatory diseases. Elevated levels of TNF-alpha have been demonstrated in Crohn's disease, psoriasis, psoriatic arthritis, and rheumatoid arthritis, suggesting a role for TNF-alpha in their pathogenesis. Although TNF-alpha plays a critical role in the activation of innate and acquired immune responses, the persistence of the immune response and inappropriate production of TNF-alpha can produce pathological changes. This volume provides a comprehensive overview of the development, pharmacology, efficacy, and safety of the currently available TNF-alpha inhibitors - etanercept, infliximab, and adalimumab. The most recent preclinical and clinical data is presented, which should be of interest to the preclinical researcher, the clinician, and the patient who wants to learn more about these therapies. TOC:Preface.- Introduction to TNF/Pathophysiology of TNF.- History of development of TNF inhibitors.- Pharmacology of TNF inhibitors.- Etanercept in rheumatology.- Etanercept in dermatology and off-label use.- Infliximab in rheumatology.- Infliximab in dermatology, gastroenterology and off-label use.- Adalimumab in rheumatology.- Adalimumab in dermatology.- A review of the safety of the tumor necrosis inhibitors infliximab, etanercept, and adalimumab.
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