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This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections:
· Evolution and detection of endogenous ADP-ribosylation
· ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs)
· ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs)
The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.
…mehr

Produktbeschreibung
This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections:

· Evolution and detection of endogenous ADP-ribosylation

· ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs)

· ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs)

The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.


Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Seitenzahl: 213
  • Erscheinungstermin: 24. Oktober 2014
  • Englisch
  • ISBN-13: 9783319107714
  • Artikelnr.: 43802649
Autorenporträt
Friedrich Koch-Nolte is a professor at University Hospital Hamburg-Eppendorf, Institute for Immunology, Hamburg, Germany
Inhaltsangabe
Part I: Evolution and Detection of Endogenous ADP-Ribosylation

The natural history of ADP-ribosyltransferases and the ADP ribosylation system

L. Aravind, Dapeng Zhang, Robson F. de Souza, Swadha Anand and Lakshminarayan M. Iyer

Identification and Analysis of ADP-ribosylated Proteins

Friedrich Haag and Friedrich Buck

Part II: ADP-Ribosylation by ARTCs (R-S-E ARTs)

Photorhabdus luminescens toxins TccC3 and TccC5: Insecticidal ADP-ribosyltransferases that modify threonine and glutamine

Klaus Aktories, Gudula Schmidt and Alexander E. Lang

Reaction mechanism of mono-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein

Hideaki Tsuge, Toshiharu Tsurumura

Regulation of nitrogenase by reversible mono-ADP-ribosylation

Vivian R. Moure, Flavia F. Costa, Leonardo M. Cruz, Fabio O. Pedrosa, Emanuel M. Souza, Xiao-Dan Li, Fritz Winkler and Luciano F. Huergo

ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells

Björn Rissiek, Friedrich Haag, Olivier Boyer, Friedrich Koch-Nolte, Sahil Adriouch

Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish

Tsuyoshi Nakano, Azusa Takahashi-Nakaguchi, Masafumi Yamamoto, and Masahiko Watanabe

Part III: ADP-Ribosylation by ARTDs (H-Y-E ARTs)

Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family

Ana Filipa Pinto and Herwig Schüler

Function and regulation of the mono-ADP-ribosyltransferase ARTD10

Max Kaufmann, Karla L. H. Feijs, and Bernhard Lüscher

Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-beta1 mono-ADP-ribosylation by ARTD15

Maria Di Girolamo