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The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body's own constituents thus preserving its integrity. Multiple mechanisms act in concert to ensure self-tolerance. Additional tolerance mechanisms, collectively referred to as dominant tolerance is by now firmly established. It will offer new conceptual insights and hopefully new tools for the sucessful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival.
yetwehopethatitwillofferinspirationandorientationtothescientistwho
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Produktbeschreibung
The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body's own constituents thus preserving its integrity. Multiple mechanisms act in concert to ensure self-tolerance. Additional tolerance mechanisms, collectively referred to as dominant tolerance is by now firmly established. It will offer new conceptual insights and hopefully new tools for the sucessful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival.
yetwehopethatitwillofferinspirationandorientationtothescientistwho wouldliketoenterthis?eld. To date, many different cells have been described that can suppress + + other cells of the immune system: CD4 CD25 regulatory T cells (Treg), + ? CD4 CD25 regulatory T cells, T regulatory 1 cells (Tr1), T-helper 3 cells + ? (Th3),CD8 CD28 Tcells,NKTcells,aswellastolerogenicdendriticcells. Suppressive CD4 T cells fall at least into two categories. So called natural VI Preface + + CD4 CD25 Tregformpartoftheintra-thymicallyselectedTcellrepertoire andapparentlyconstituteadistinctlineage. Incontrast,"adaptive"regulatory Tcellsareinstructedintheperipherytobecomesuppressivecells,theyform + + amoreheterogeneousgroupincludingCD4 CD25 Treg,Tr1,andTh3cells. As natural Treg are so far the best characterized entity, the ?rst three contributionsofthisvolume(C. Cozzoetal. ,C. -S. Hsiehetal. ,andL.
  • Produktdetails
  • Current Topics in Microbiology and Immunology 293
  • Verlag: Springer / Springer, Berlin
  • Artikelnr. des Verlages: 11019459, 978-3-540-24444-8
  • 2005
  • Seitenzahl: 344
  • Erscheinungstermin: 23. Mai 2005
  • Englisch
  • Abmessung: 241mm x 160mm x 26mm
  • Gewicht: 604g
  • ISBN-13: 9783540244448
  • ISBN-10: 3540244441
  • Artikelnr.: 13904915
Inhaltsangabe
Preface.- Selection of CD4+CD25+ Regulatory T Cells by Self-Peptides.- The Role of TCR Specificity in Naturally Arising CD25+ CD4+ Regulatory T Cell Biology.- Thymic Commitment of Regulatory T Cells Is a Pathway of TCR-Dependent Selection That 'Isolates' Repertoires Undergoing Positive or Negative Selection.- Selection and Behaviour of CD4+CD25+ T Cells in vivo: Lessons from T Cell Receptor Transgenic Models.- Migration Matters: Functional Properties of Naïve- and Effector/Memory-Like Regulatory T Cell Subsets.- Peripheral Generation and Function of CD4+CD25+ Regulatory T Cells.- Dendritic Cells, Key Cells for the Induction of Regulatory T Cells?.- Autoimmune Gastritis Is a Well-Defined Autoimmune Disease Model for the Study or CD4+CD25+ T Cell-Mediated Suppresion.- Regulatory T Cells in Experimental Colitis.- Autoimmune Ovarian Disease in Day 3-Thymectomized Mice: the Neonatal Time Window, Antigen Specificity of Disease Suppression, and Genetic Control.- Regulatory T Cells in Transplantation Tolerance. Infectious Tolerance.- CD4+CD25+ Regulatory T Cells in Hematopoietic Stem Cell Transplantation.- ..................- Phenotypic and Functional Differences Between Human CD4+CD25+ and Type 1 Regulatory T Cells.- Subject Index.