Produktbild: Neuroinflammation and Biomarker Discovery
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Neuroinflammation and Biomarker Discovery From Mechanisms to Clinical Application

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Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

01.03.2027

Herausgeber

Singh Arun Kumar + weitere

Verlag

Elsevier

Seitenzahl

350

Maße (L/B)

22,9/15,2 cm

Sprache

Englisch

ISBN

978-0-443-48529-9

Beschreibung

Portrait

Arun Kumar Singh is an Assistant Professor in the Department of Pharmacy at University School of Pharmaceutical Sciences, Rayat Bahra University V.P.O. Sahauran, India. He completed his M.Pharm in Pharmaceutics from Galgotias University, Greater Noida. His research interests include nano-formulation, blockchain, IoT, machine learning, artificial intelligence, big data analytics, cancer biology, and neuroscience. He has contributed to academic books and book chapters and has published review articles in the areas of pharmaceutical sciences and healthcare technology. His work focuses on interdisciplinary approaches integrating pharmaceutical research with emerging digital and computational technologies.

Dr. Meenakshi Dhanawat is an Associate Professor at the Amity Institute of Pharmacy, Amity University Haryana, with over 18 years of experience in Pharmaceutical Sciences and Medicinal Chemistry. She completed her Master's degree at NIPER, Mohali, focusing on glycosylamino acids, and earned her Ph.D. from IIT-BHU, Varanasi, investigating CNS drug delivery targeting 5HT1A/2A receptors. Her research encompasses synthetic and heterocyclic chemistry, nanotechnology, drug delivery systems, prodrug design, complexation, polymer chemistry, and herbal drug extraction. Dr. Dhanawat has received notable international recognition, including a travel grant from the AAPS Drug Delivery and Development section for the 2010 National Biotechnology Conference in California, and international travel grants from DBT and DST, Government of India, for conferences in California and Munich. Her distinguished honors include the Rajiv Gandhi National Fellowship, affirming her sustained contributions to pharmaceutical research and academic excellence.

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

01.03.2027

Herausgeber

Verlag

Elsevier

Seitenzahl

350

Maße (L/B)

22,9/15,2 cm

Sprache

Englisch

ISBN

978-0-443-48529-9

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: GPSR Kontakt

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  • Produktbild: Neuroinflammation and Biomarker Discovery
  • SECTION I: MOLECULAR AND CELLULAR FRAMEWORK OF NEUROINFLAMMATION
    1. The Neuroimmune Axis: Cellular Interfaces and Bidirectional Signaling
    2. Microglial Activation States: From Homeostasis to Neurotoxicity
    3. Astrocyte and Oligodendrocyte Contribution to Neuroinflammation
    4. Pattern Recognition Receptors and CNS Innate Immunity
    5. Molecular Triggers: DAMPs, PAMPs, and the Inflammasome Complex
    6. Blood-Brain Barrier Breakdown and Immune Cell Trafficking

    SECTION II: SIGNALING NETWORKS IN NEUROINFLAMMATORY PATHWAYS
    7. NF-¿B and MAPK Pathways: Master Regulators of Inflammatory Transcription
    8. JAK/STAT Signaling and Interferon Regulatory Networks in the CNS
    9. Redox Signaling, ROS Generation, and Mitochondrial Dysfunction
    10. Autophagy, Ubiquitin-Proteasome System, and Immune Regulation

    SECTION III: ADVANCED PLATFORMS FOR BIOMARKER DISCOVERY
    11. Transcriptomic Approaches: Bulk RNA-Seq and Single-Cell Resolution
    12. Proteomics and Phosphoproteomics in Neuroinflammation
    13. Lipidomics and Metabolomics of Inflammatory Brain States
    14. Epigenomic Biomarkers: DNA Methylation, Histone Modifications, and miRNAs
    15. Extracellular Vesicles and Exosomal Biomarkers in Neuroinflammatory Diseases
    16. Imaging Biomarkers: PET, MRI, and Molecular Neuroimaging

    SECTION IV: DISEASE-SPECIFIC BIOMARKER LANDSCAPES
    17. Neuroinflammation in Alzheimer's Disease: Aß, Tau, and Microglial Dysfunction
    18. Biomarkers of Neuroinflammation in Parkinson’s Disease and Lewy Body Disorders
    19. Multiple Sclerosis and Autoimmune Neuroinflammation
    20. Stroke, Traumatic Brain Injury, and Post-Injury Neuroinflammation
    21. Vascular Ageing and its Impact on Brain Health
    22. Epstein-Barr Virus (EBV) and Multiple Sclerosis
    23. Herpes Simplex Virus (HSV) and Alzheimer's Disease

    SECTION V: TRANSLATIONAL APPLICATIONS AND FUTURE DIRECTIONS
    24. Biomarkers in Clinical Trials: Stratification, Monitoring, and Endpoints
    25. Toward Personalized Neuroimmunology: AI-Driven Integration of Multi-Omics Data