Produktbild: Targeted Protein Degradation Technologies

Targeted Protein Degradation Technologies

154,99 €

inkl. gesetzl. MwSt., Versandkostenfrei


Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

28.07.2025

Herausgeber

Jiangjiang Qin + weitere

Verlag

Elsevier Science & Technology

Seitenzahl

402

Maße (L/B/H)

22,6/18,8/2 cm

Gewicht

839 g

Sprache

Englisch

ISBN

978-0-443-21816-3

Beschreibung

Portrait

Dr. Jiangjiang Qin is currently a Professor of Cancer Pharmacology and Drug Discovery at the Institute of Basic Medicine and Cancer (IBMC), and the Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital). He received his PhD in Biomedical Engineering with the highest honor from Shanghai Jiao Tong University, China before completing postdoctoral training in cancer biology, pharmacology, and molecular therapeutics at Texas Tech University Health Sciences Center (TTUHSC). Following this he was appointed as Senior Research Associate at the university. Dr. Qin's research mainly focuses on the discovery and development of novel, effective, and safe anticancer agents as well as demonstrating the molecular targets and mechanisms of action. He has published more than 120 research papers and reviews. He is an Associate Editor of Frontiers in Pharmacology and Frontiers in Oncology and an editorial board member of more than 10 scientific journals.Dr. Xin Luan received his B.Sc. in Pharmaceutics from China Pharmaceutical University (2011) and was awarded his PhD degree in Pharmacology at Shanghai Jiao Tong University (2016). He subsequently worked for two years as post-doctor at the University of Michigan under the guidance of Professor Duxin Sun. In 2018, he joined Shanghai University of Traditional Chinese Medicine (SHUTCM), and is currently appointed as a professor. He is currently working on anti-tumor pharmacology and delivery systems of natural products. Dr. Luan has published more than 60 research papers and reviews.Dr. Weidong Zhang obtained his BSc and Master degree in Natural Medicinal Chemistry from the Second Military Medical University in 1988 and 1991, respectively. He received his PhD in Natural Medicinal Chemistry from the Shanghai Institute of Pharmaceutical Industry (1998), under the supervision of Professor HuiTing Li. He is currently a professor of the Shanghai University of Traditional Chinese Medicine and Second Military Medical University. His research mainly focuses on Chinese medicine formulas, isolation, structural identification and modification, total synthesis, and structure-activity relationships of bioactive natural products. Dr. Zhang has published more than 500 peer-reviewed research papers and reviews.

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

28.07.2025

Herausgeber

Verlag

Elsevier Science & Technology

Seitenzahl

402

Maße (L/B/H)

22,6/18,8/2 cm

Gewicht

839 g

Sprache

Englisch

ISBN

978-0-443-21816-3

EU-Ansprechpartner

Elsevier B.V.
Radarweg 29
1043 NX Amsterdam
NL
productsafety@elsevier.com

Herstelleradresse

Elsevier Science & Technology
London Wall 125
EC2Y 5AS London
GB
tradeorders@elsevier.com

Noch keine Bewertungen vorhanden

Verfassen Sie die erste Bewertung zu diesem Artikel

Helfen Sie anderen Kundinnen und Kunden durch Ihre Meinung.

Kundinnen und Kunden meinen

Bewertungen (0)

Die Leseprobe wird geladen.
  • Produktbild: Targeted Protein Degradation Technologies
  • Part 1: Introduction
    1. Mechanisms of protein degradation
    2. Overview of targeted protein degradation

    Part 2: Summary of targeted protein degradation
    3. Protease-mediate degradation
    4. PROTAC
    5. AbTAC
    6.¿ Molecular glues
    7.¿ Hydrophobic tagging technology
    8. Lysosome-mediate degradation
    9. LYTACs
    10.¿ Bispecific Apt amer Chimera (BIAC)
    11. ¿GlueTAC
    12. AUTACs
    13. ATTECs
    14. AUTOTAC

    Part 3:¿ Degradation of Proteins¿of Interest
    15. Degraders of signal transduction receptors
    16. Degraders of membrane-associated proteins
    17. Degraders of cell cycle- and anti-apoptosis-related proteins
    18.¿ Degraders of proteins in epigenetic regulation
    19. Degraders of proteins involved in transcription nuclear hormone receptors
    20. Transcription factor degraders

    Part 4: Clinical applications of targeted protein degradation
    21. Clinical development of protein degraders