CD34+ a Novel Predictor of Vascular Events in Sickle Cell Disease CD34+ Hematopoietic Stem Cell Count as a Novel Predictor of Vascular Event in Sickle Cell Disease Patients. DE
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- Englisch ausgewählt
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Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
30.09.2024
Verlag
LAP LAMBERT Academic PublishingSeitenzahl
112
Maße (L/B/H)
22/15/0,8 cm
Gewicht
185 g
Sprache
Englisch
ISBN
978-620-8-11833-4
Our aim is to evaluate circulating CD34 as a novel predictive marker of occurrence of vascular event in Children with Sickle Cell Disease in their steady state and relate levels to severity of VEs in the following 6 months.Patient and Methods: This study was an exploratory study, conducted at Pediatrics Hematology-Oncology Unit at Ain Shams University Children's Hospital, where 50 children with sickle cell disease were enrolled at their steady state (defined as 2 months free from any Vascular Event prior to the study), aged 6 months - 16 years. Flow cytometry was done for quantification of circulating CD34+ at inclusion and compared to age and sex matched control and patients were followed up for 6 months for vascular events. Results: There is statistically significant higher level of CD34+ among SCD patients compared to age and sex matched control with p value < 0.001.Circulating CD34+ showed significantly higher level in patients who developed systemic vascular events after 6 months of follow up with p value 0.022. There was no statistically significant correlation between circulating CD34+ and severity of peripheral vascular events (or any need for hospitalization).
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