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Produktbild: Bacterial Enzymes as Targets for Drug Discovery
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Bacterial Enzymes as Targets for Drug Discovery Meeting the Challenges of Antibiotic Resistance

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Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

28.11.2024

Herausgeber

Punit Kaur + weitere

Verlag

Elsevier Science & Technology

Seitenzahl

496

Maße (L/B/H)

23,4/19,3/2,4 cm

Gewicht

1020 g

Sprache

Englisch

ISBN

978-0-443-22222-1

Beschreibung

Portrait

Dr. Kaur’s specialties include Bioinformatics, Structural Biology, X-ray Crystallography, and Rational Structure-Based Drug Design. Her research focuses on clinically relevant bacterial pathogens where a multidisciplinary approach is adopted to understand the antibacterial resistance mechanisms and design of novel inhibitory molecules. She has published more than 240 original publications, reviews and chapters in the field of bioinformatics, biophysical enzymatic activity and structural biology.

Dr. Priyanka Sharma is a postdoctoral student with the biomedical Informatics department at the ICMR. Her work focuses on the field of computational biology involving structural bioinformatics and genomics of bacterial pathogens. She has published widely in the field of clinical bacteriology and is the author of over 30 research papers, reviews and chapters. She has work experience in field of antimicrobial resistance due to enzymatic mutations.

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

28.11.2024

Herausgeber

Verlag

Elsevier Science & Technology

Seitenzahl

496

Maße (L/B/H)

23,4/19,3/2,4 cm

Gewicht

1020 g

Sprache

Englisch

ISBN

978-0-443-22222-1

EU-Ansprechpartner

Zeitfracht Medien GmbH
Ferdinand-Jühlke-Straße 7
99095 Erfurt
DE
produktsicherheit@zeitfracht.de

Herstelleradresse

Elsevier Science & Technology
London Wall 125
EC2Y 5AS London
GB
tradeorders@elsevier.com

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  • Produktbild: Bacterial Enzymes as Targets for Drug Discovery
  • Part I Primer of antibiotic discovery process
    1. Antibacterial drug discovery: A Silent Pandemic
    2. Current scenario and future prospective of drug discovery and development against bacterial enzymes
    3. Clinical diagnostics of bacterial infections and their resistance to Antibiotics - Current State and Novel Enabling Technologies Implementation Perspectives
    4. An Odyssey into Phylogenetic Functional Conservation of Novel Antibacterial Targets in Human Pathogens
    5. Validation of drug targets using molecular methodologies and enzymatic activity assays for validation of inhibitory potential
    6. Computational tools to identify potential drug targets in bacteria
    7. Antimicrobial drug resistance and bypassing strategies
    Part II Bacterial enzyme as drug targets
    8. Designing Tomorrow's Antibiotics: Cutting-Edge Strategies and Technologies
    9. Inhibiting the replication by targeting topoisomerases
    10. Role of beta lactamases in antibiotic drug discovery
    11. Selective vs broad spectrum inhibition of novel outer membrane targets in Gram negatives
    12. Ribosomal binding antibacterial agents
    13. RNA polymerase: A key target for Novel Antimicrobial Therapeutic Strategies
    14. Colistin resistance and strategies against superbug, where we are?
    15. Deoxythymidine pathway enzymes as an antibacterial target
    16. Arresting the peptidoglycan synthesis to kill the bacteria
    17. Clp protease complex as a therapeutic target for tuberculosis
    18. PlaF: a bacterial Lands cycle phospholipase A mediating membrane phospholipid degradation and virulence adaptation
    19. Bacterial TIR domain-containing proteins as drug targets
    20. Drug Repurposing: Tackling the antibiotic resistance with existing therapeutics