Reversible Ligand Binding Theory and Experiment
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Form:Einzelkauf Download
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Sprache:Englisch
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eBook Format:PDF
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101,99 €
inkl. gesetzl. MwSt.Beschreibung
Produktdetails
Format
Kopierschutz
Ja
Family Sharing
Nein
Text-to-Speech
Nein
Erscheinungsdatum
24.10.2017
Verlag
Wiley-IEEE PressSeitenzahl
304 (Printausgabe)
Dateigröße
6764 KB
Auflage
1. Auflage
Sprache
Englisch
EAN
9781119238478
Presents the physical background of ligand binding and instructs on how experiments should be designed and analyzed
Reversible Ligand Binding: Theory and Experiment discusses the physical background of protein-ligand interactions--providing a comprehensive view of the various biochemical considerations that govern reversible, as well as irreversible, ligand binding. Special consideration is devoted to enzymology, a field usually treated separately from ligand binding, but actually governed by identical thermodynamic relationships. Attention is given to the design of the experiment, which aids in showing clear evidence of biochemical features that may otherwise escape notice. Classical experiments are reviewed in order to further highlight the importance of the design of the experiment. Overall, the book supplies students with the understanding that is necessary for interpreting ligand binding experiments, formulating plausible reaction schemes, and analyzing the data according to the chosen model(s).
Topics covered include: theory of ligand binding to monomeric proteins; practical considerations and commonly encountered problems; oligomeric proteins with multiple binding sites; ligand binding kinetics; hemoglobin and its ligands; single-substrate enzymes and their inhibitors; two-substrate enzymes and their inhibitors; and rapid kinetic methods for studying enzyme reactions.
* Bridges theory of ligand binding and allostery with experiments
* Applies historical and physical insight to provide a clear understanding of ligand binding
* Written by a renowned author with long-standing research and teaching expertise in the area of ligand binding and allostery
* Based on FEBS Advanced Course lectures on the topic
Reversible Ligand Binding: Theory and Experiment is an ideal text reference for students and scientists involved in biophysical chemistry, physical biochemistry, biophysics, molecular biology, protein engineering, drug design, pharmacology, physiology, biotechnology, and bioengineering.
Reversible Ligand Binding: Theory and Experiment discusses the physical background of protein-ligand interactions--providing a comprehensive view of the various biochemical considerations that govern reversible, as well as irreversible, ligand binding. Special consideration is devoted to enzymology, a field usually treated separately from ligand binding, but actually governed by identical thermodynamic relationships. Attention is given to the design of the experiment, which aids in showing clear evidence of biochemical features that may otherwise escape notice. Classical experiments are reviewed in order to further highlight the importance of the design of the experiment. Overall, the book supplies students with the understanding that is necessary for interpreting ligand binding experiments, formulating plausible reaction schemes, and analyzing the data according to the chosen model(s).
Topics covered include: theory of ligand binding to monomeric proteins; practical considerations and commonly encountered problems; oligomeric proteins with multiple binding sites; ligand binding kinetics; hemoglobin and its ligands; single-substrate enzymes and their inhibitors; two-substrate enzymes and their inhibitors; and rapid kinetic methods for studying enzyme reactions.
* Bridges theory of ligand binding and allostery with experiments
* Applies historical and physical insight to provide a clear understanding of ligand binding
* Written by a renowned author with long-standing research and teaching expertise in the area of ligand binding and allostery
* Based on FEBS Advanced Course lectures on the topic
Reversible Ligand Binding: Theory and Experiment is an ideal text reference for students and scientists involved in biophysical chemistry, physical biochemistry, biophysics, molecular biology, protein engineering, drug design, pharmacology, physiology, biotechnology, and bioengineering.
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