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Produktbild: Nuclear Receptors: From Structure to the Clinic

Nuclear Receptors: From Structure to the Clinic

98,99 €

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

22.10.2016

Abbildungen

XI, 236 p. 43 illus., 33 illus. in color.

Herausgeber

Iain J. McEwan + weitere

Verlag

Springer

Seitenzahl

236

Maße (L/B/H)

23,5/15,5/1,4 cm

Gewicht

382 g

Auflage

1oftcover reprint of the original 1st ed. 2015

Sprache

Englisch

ISBN

978-3-319-37128-3

Beschreibung

Rezension

“Given the rapid advances in the field of nuclear
receptor research, especially their role in cell proliferation, metabolism, and
homeostasis, which make them prime targets for a wide range of diseases such as
cancer and metabolic diseases, this book does an excellent job of covering
their structure and function and translational opportunities for drug
discovery. … The book targets students, scientists, and other clinicians such
as oncologists and endocrinologists interested in the field of nuclear
receptors.” (Omer Iqbal, Doody’s Book Reviews, October, 2015)

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

22.10.2016

Abbildungen

XI, 236 p. 43 illus., 33 illus. in color.

Herausgeber

Verlag

Springer

Seitenzahl

236

Maße (L/B/H)

23,5/15,5/1,4 cm

Gewicht

382 g

Auflage

1oftcover reprint of the original 1st ed. 2015

Sprache

Englisch

ISBN

978-3-319-37128-3

Herstelleradresse

Springer-Verlag KG
Sachsenplatz 4-6
1201 Wien
AT

Email: GPSR Kontakt

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  • Produktbild: Nuclear Receptors: From Structure to the Clinic

  • 1. Twenty-five Years of Nuclear Receptor Structure Analysis: From the Laboratory to the Clinic.- Part A. ALLOSTERIC REGULATION AND NUCLEAR RECEPTOR COMPLEX DYNAMICS. -2. Corticosteroid Receptors.- 3. Glucocorticoid Receptor Structure and Function.- 4. What Determines the Difference in DNA Binding Between the Androgen and the Glucocorticoid Receptors?.- 5. Allosteric Regulation and Intrinsic Disorder in Nuclear Hormone Receptors.- 6. Structural Analyses of Ordered and Disordered Regions in Ecdysteroid Receptor.- 7. Structural Analysis of Heterodimeric Nuclear Receptors.- Part B. NUCLEAR RECEPTOR CO-REGULATORY PROTEIN INTERACTIONS.- 8. Primate-specific Multi-functional Androgen Receptor Coregulator and Proto-oncogene Melanoma Antigen-A11 (MAGE-A11).- 9. Assembly and Regulation of Nuclear Receptor Corepressor Complexes.- Part C. TAKING NUCLEAR RECEPTOR STRUCTURE INTO THE CLINIC.- 10. Thinking Outside the Box: Alternative Binding Sites in the Ligand Binding Domain of Nuclear Receptors.-11. Selective Estrogen Receptor Modulators (SERMs) and Selective Androgen Receptor Modulators (SARMs).