Drug Absorption Studies In Situ, In Vitro and In Silico Models
-
- Hardcover
- Taschenbuch ausgewählt
-
Sprache:Englisch
187,99 €
UVP
213,99 €
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
23.08.2016
Abbildungen
XXII, 696 p.
Herausgeber
Carsten Ehrhardt + weitereVerlag
Springer UsSeitenzahl
696
Maße (L/B/H)
25,4/17,8/3,9 cm
Gewicht
1337 g
Sprache
Englisch
ISBN
978-1-4899-7754-0
In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These
in vitro
models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex
in vivo
situation,
in vitro
models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening.
Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary
in vitro
techniques for drug absorption studies. In addition, chapters on high-throughput assays,
in vitro
-
in vivo
correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.
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