Produktbild: Neonatal Haematology

Neonatal Haematology A Practical Guide

161,99 €

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

13.09.2022

Verlag

John Wiley & Sons

Seitenzahl

304

Maße (L/B/H)

24,4/17/2 cm

Gewicht

726 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-37158-8

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

13.09.2022

Verlag

John Wiley & Sons

Seitenzahl

304

Maße (L/B/H)

24,4/17/2 cm

Gewicht

726 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-37158-8

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: GPSR Kontakt

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  • Produktbild: Neonatal Haematology
  • Preface viii
     
    Abbreviations x
     
    1 The full blood count and blood film in healthy term and preterm neonates 1
     
    Introduction 1
     
    Brief outline of the ontogeny of haemopoiesis 1
     
    Properties of fetal haemopoietic stem and progenitor cells 2
     
    Red blood cell production and development in the fetus and neonate 5
     
    Erythropoietin production in the fetus and neonate 6
     
    Haemoglobin synthesis and red blood cell production in the fetus and newborn 6
     
    Red blood cell lifespan and the red blood cell membrane in the fetus and neonate 9
     
    Red blood cell metabolism in the fetus and neonate 10
     
    Iron metabolism in the fetus and neonate 11
     
    Normal values for red blood cell parameters in the fetus and neonate 12
     
    Leucocytes in the fetus and newborn 17
     
    Leucocyte production and function in the fetus and neonate 18
     
    Platelets and megakaryocytes in the fetus and neonate 23
     
    Developmental megakaryopoiesis and thrombopoiesis 23
     
    Platelet numbers in the neonate and fetus - normal values 24
     
    Neonatal platelet function 25
     
    Practical problems in interpreting neonatal blood counts and films 25
     
    Sample quality/artefacts 25
     
    Site of sampling 26
     
    Gestational age and postnatal age 27
     
    Pregnancy-associated complications and mode of delivery 28
     
    References 28
     
    2 Red cell disorders: Anaemia, jaundice, polycythaemia and cyanosis 38
     
    Neonatal anaemia 38
     
    Definition and clinical significance of neonatal anaemia 38
     
    Neonatal anaemia due to reduced red cell production 39
     
    Neonatal anaemia due to increased red cell destruction 47
     
    Neonatal anaemia due to haemoglobinopathies and other microcytic anaemias 67
     
    Neonatal anaemia due to blood loss 76
     
    Anaemia of prematurity 81
     
    A simple diagnostic approach to neonatal anaemia 83
     
    Neonatal polycythaemia 85
     
    Haematological causes of cyanosis 86
     
    Principles of red cell transfusion in neonates 86
     
    Illustrative cases 88
     
    Abbreviations used in the illustrative cases 110
     
    References 110
     
    3 Neonatal infection and leucocyte disorders 128
     
    Leucocyte abnormalities in neonatal systemic disease 128
     
    Increases in leucocyte numbers 128
     
    Neonatal infection and its differential diagnosis: clues from the blood count and blood film 135
     
    Storage disorders: diagnostic clues from the blood film 144
     
    Neonatal neutropenia 145
     
    Definition and causes of neutropenia 145
     
    Immune neutropenia 148
     
    Inherited congenital or neonatal neutropenia 150
     
    Haematological features of neonates with Down syndrome 154
     
    Congenital leukaemia 154
     
    Leukaemia and preleukaemia in neonates with Down syndrome 156
     
    Acute leukaemia in neonates without Down syndrome 160
     
    Juvenile myelomonocytic leukaemia and Noonan syndrome myeloproliferative disorder 168
     
    Illustrative cases 169
     
    Abbreviations used in the illustrative cases 176
     
    References 176
     
    4 Disorders of platelets and coagulation, thrombosis and blood transfusion 190
     
    Thrombocytopenia overview 190
     
    Causes of neonatal thrombocytopenia: a practical classification based on age at onset 192
     
    Fetal thrombocytopenia 194
     
    Early-onset neonatal thrombocytopenia (presenting at
     
    Late-onset neonatal thrombocytopenia (presenting at >72 hours of age) 196
     
    Conditions leading to clinically significant thrombocytopenia in the neonate 197
     
    Fetal/neonatal alloimmune thrombocytopenia 197