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Gene Therapy of Solid Cancers Methods and Protocols

Aus der Reihe Methods in Molecular Biology
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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

15.06.2015

Abbildungen

XIII, 60 illus., 30 illus. in color., schwarz-weiss Illustrationen, farbige Illustrationen

Herausgeber

Wolfgang Walther + weitere

Verlag

Springer Us

Seitenzahl

387

Maße (L/B/H)

26/18,3/2,8 cm

Gewicht

954 g

Auflage

2015

Sprache

Englisch

ISBN

978-1-4939-2726-5

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

15.06.2015

Abbildungen

XIII, 60 illus., 30 illus. in color., schwarz-weiss Illustrationen, farbige Illustrationen

Herausgeber

Verlag

Springer Us

Seitenzahl

387

Maße (L/B/H)

26/18,3/2,8 cm

Gewicht

954 g

Auflage

2015

Sprache

Englisch

ISBN

978-1-4939-2726-5

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: GPSR Kontakt

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  • Produktbild: Gene Therapy of Solid Cancers
  • Produktbild: Gene Therapy of Solid Cancers

  • Part I: Immunogene Therapy

    1. Aptamer Targeting the ERBB2 Receptor Tyrosine Kinase for Applications in Tumor Therapy

    Georg Mahlknecht, Michael Sela, and Yosef Yarden

     

    2. Gene Gun Her2/neu DNA Vaccination: Evaluation Of Vaccine Efficacy in a Syngeneic Her2/neu Mouse Tumor Model

    Tam Nguyen-Hoai, Antonio Pezzutto, and Jörg Westermann

     

    3. MIDGE Technology for the Production of a Fourfold Gene-Modified, Allogenic Cell-Based Vaccine For Cancer Therapy

    Manuel Schmidt, Barbara Volz, Patrick Großmann, Kerstin Heinrich, and Burghardt Wittig

     

    Part II: Suicide Gene Therapy

    4. Evaluation of Bystander Cell Killing Effects in Suicide Gene Therapy of Cancer: Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis

    Takeya Sato, Anton Neschadim, Ryo Nakagawa, Teruyuki Yanagisawa, and Jeffrey A. Medin

     

    5. Oncoleaking: Use of the Pore-forming Clostridium perfringens Enterotoxin (CPE) for Suicide Gene Therapy

    Jessica Pahle, Jutta Aumann, Dennis Kobelt, and Wolfgang Walther

     

    6. iCaspase 9 Suicide Gene System

    Xiaoou Zhou, Antonio Di Stasi, and Malcolm K. Brenner

     

    Part III: Gene Replacement Therapies

    7. p53-encoding pDNA Purification by Affinity-Chromatography for Cancer Therapy

    Ângela Sousa, João A. Queiroz, and Fani Sousa

     

    8. A qRT-PCR Method for Determining the Biodistribution Profile of a miR-34a Mimic

    Kevin Kelnar and Andreas G. Bader

     

    Part IV: Gene Suppression and Signaling Modulation Therapy

    9. Design and Selection of Antisense Oligonucleotides Targeting Transforming Growth Factor Beta (TGF-b) Isoform mRNAs for the Treatment of Solid Tumors

    Frank Jaschinski, Hanna Korhonen, and Michel Janicot

     

    10. RNA Interference for Antimetastatic Therapy

    Mathias Dahlmann  and Ulrike Stein 

     

    11. STAT3 Decoy ODN Therapy for Cancer

    Xiaoxia Sun and Jian Zhang

     

    Part V: Oncolytic Virotherapy and Bacterial Vectors for Cancer Treatment

    12. Oncolytic Viral Therapy using Reovirus

    Chandini Thirukkumaran and Don G. Morris

     

    13. Use of GLV-1h68 for Vaccinia Virotherapy and Monitoring

    Alexa Frentzen, Ulrike Geissinger, Desislava Tsoneva, and Jochen Stritzker

     

    14. Back To The Future: Are Tumor-Targeting Bacteria The Next Generation Cancer Therapy?

    Robert M. Hoffman

     

     

    Part IV: Clinical Application of Cancer Gene Therapy

    15. Ethics of Cancer Gene Transfer Clinical Research

    Jonathan Kimmelman

     

    16. Planning an Academic Clinical Trial

    Kim M. Champion and Gemma R. Jones

     17. Production of Plasmid DNA as Pharmaceutical

    Marco Schmeer and Martin Schleef

     

    18. Minicircle - Next Generation DNA Vectors for Vaccination

    Schleef, M., Schirmbeck, R., Michael Reiser2, M.-L. Michel, and Schmeer, M.

     

    VII: Protocols of Clinical Cancer Gene Therapy

    19. A Phase 2, Open-Label, Randomized Study of Pexa-Vec (JX-594) Administered by Intratumoral Injection in Patients with Unresectable Primary Hepatocellular Carcinoma

    Caroline J. Breitbach, Anne Moon, James Burke, Tae-Ho Hwang, and David H. Kirn

     20. Antiangiogenic Metargidin Peptide (AMEP) Gene Therapy in Disseminated Melanoma

    Iben Spanggaard and Julie Gehl

     21. Clinical Evaluation of ErbB-targeted CAR T-cells, Following Intra-Cavity Delivery in Patients with ErbB-Expressing Solid Tumors

    Sophie Papa, May van Schalkwyk, and John Maher