Mitochondrial Biology New Perspectives
Aus der Reihe
Novartis Foundation Symposium
166,99 €
inkl. gesetzl. MwSt.Beschreibung
Produktdetails
Format
Kopierschutz
Ja
Family Sharing
Nein
Text-to-Speech
Nein
Erscheinungsdatum
22.10.2007
Herausgeber
Derek J. Chadwick + weitereVerlag
John Wiley & Sons IncSeitenzahl
254 (Printausgabe)
Dateigröße
14495 KB
Auflage
1. Auflage
Sprache
Englisch
EAN
9780470725191
With the recent renaissance in mitochondrial biology and increasing
recognition of their role in many diseases, this book provides a
timely summary of the current state-of-the-art in mitochondrial
research. The book opens with the regulation of mitochondrial
replication and biogenesis and reviews the mechanisms and
functional consequences of mitochondrial fission and fusion.
Further chapters address mitochondria and oxidative stress and
their roles in cell signalling and cell death. The book includes
extensive, fascinating discussion of the biochemistry of
mitochondrial cell signalling (especially involving calcium) and of
oxidative stress. The nature of the proteins engaged in these
processes, many only recently discovered, is covered in detail.
Mitochondria have been strongly implicated in neurodegenerative
diseases such as Parkinson's, Huntington's and
amyotrophic lateral sclerosis. They are also affected in cancer,
ageing and cardiovascular disease. The final section of the book
reviews mitochondrial mutations and their consequences in ageing
and other phenotypic manifestations. The authors discuss how
mitochondrial proteins might constitute important therapeutic
targets and describe initial attempts to develop compounds that can
regulate their function.
recognition of their role in many diseases, this book provides a
timely summary of the current state-of-the-art in mitochondrial
research. The book opens with the regulation of mitochondrial
replication and biogenesis and reviews the mechanisms and
functional consequences of mitochondrial fission and fusion.
Further chapters address mitochondria and oxidative stress and
their roles in cell signalling and cell death. The book includes
extensive, fascinating discussion of the biochemistry of
mitochondrial cell signalling (especially involving calcium) and of
oxidative stress. The nature of the proteins engaged in these
processes, many only recently discovered, is covered in detail.
Mitochondria have been strongly implicated in neurodegenerative
diseases such as Parkinson's, Huntington's and
amyotrophic lateral sclerosis. They are also affected in cancer,
ageing and cardiovascular disease. The final section of the book
reviews mitochondrial mutations and their consequences in ageing
and other phenotypic manifestations. The authors discuss how
mitochondrial proteins might constitute important therapeutic
targets and describe initial attempts to develop compounds that can
regulate their function.
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