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Produktbild: Methods and Applications of Statistics in Clinical Trials, Volume 2

Methods and Applications of Statistics in Clinical Trials, Volume 2 Planning, Analysis, and Inferential Methods

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Beschreibung

Methods and Applications of Statistics in Clinical Trials, Volume 2: Planning, Analysis, and Inferential Methods includes updates of established literature from the Wiley Encyclopedia of Clinical Trials as well as original material based on the latest developments in clinical trials. Prepared by a leading...

Beschreibung

Methods and Applications of Statistics in Clinical Trials, Volume 2: Planning, Analysis, and Inferential Methods includes updates of established literature from the Wiley Encyclopedia of Clinical Trials as well as original material based on the latest developments in clinical trials. Prepared by a leading expert, the second volume includes numerous contributions from current prominent experts in the field of medical research. In addition, the volume features:
 
* Multiple new articles exploring emerging topics, such as evaluation methods with threshold, empirical likelihood methods, nonparametric ROC analysis, over- and under-dispersed models, and multi-armed bandit problems
 
* Up-to-date research on the Cox proportional hazard model, frailty models, trial reports, intrarater reliability, conditional power, and the kappa index
 
* Key qualitative issues including cost-effectiveness analysis, publication bias, and regulatory issues, which are crucial to the planning and data management of clinical trials

Produktdetails

Einband

Gebundene Ausgabe
Erscheinungsdatum

09.06.2014
Herausgeber N. Balakrishnan
Verlag John Wiley & Sons Inc

Produktdetails

Einband

Gebundene Ausgabe
Erscheinungsdatum

09.06.2014
Herausgeber N. Balakrishnan
Verlag John Wiley & Sons Inc
Seitenzahl

960
Maße (L/B/H)

26,1/18,7/5,5 cm
Gewicht

1842 g
Auflage

1. Auflage
Sprache

Englisch
ISBN

978-1-118-30476-1
Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: Methods and Applications of Statistics in Clinical Trials, Volume 2
  • Contributors xix
     
    Preface xxiii
     
    1 Analysis of Over- and Underdispersed Data 1
     
    2 Analysis of Variance (ANOVA) 10
     
    3 Assessment of Health-Related Quality of Life 26
     
    4 Bandit Processes and Response-Adaptive Clinical Trials: The Art of Exploration Versus Exploitation 40
     
    5 Bayesian Dose-Finding Designs in Healthy Volunteers 51
     
    6 Bootstrap 62
     
    7 Conditional Power in Clinical Trial Monitoring 102
     
    8 Cost-Effectiveness Analysis 111
     
    9 Cox-Type Proportional Hazards Models 126
     
    10 Empirical Likelihood Methods in Clinical Experiments 146
     
    11 Frailty Models 166
     
    12 Futility Analysis 174
     
    13 Imaging Science in Medicine I: Overview 187
     
    14 Imaging Science in Medicine, II: Basics of X-Ray Imaging 213
     
    15 Imaging Science in Medicine, III: Digital (21st Century) X-Ray Imaging 264
     
    16 Intention-to-Treat Analysis 313
     
    17 Interim Analyses 323
     
    18 Interrater Reliability 334
     
    19 Intrarater Reliability 340
     
    20 Kaplan-Meier Plot 357
     
    21 Logistic Regression 365
     
    22 Metadata 380
     
    23 Microarray 392
     
    24 Multi-Armed Bandits, Gittins Index, and Its Calculation 416
     
    25 Multiple Comparisons 436
     
    26 Multiple Evaluators 446
     
    27 Noncompartmental Analysis 457
     
    28 Nonparametric ROC Analysis for Diagnostic Trials 483
     
    29 Optimal Biological Dose for Molecularly Targeted Therapies 496
     
    30 Over- and Underdispersion Models 506
     
    31 Permutation Tests in Clinical Trials 527
     
    32 Pharmacoepidemiology, Overview 536
     
    33 Population Pharmacokinetic and Pharmacodynamic Methods 551
     
    34 Proportions: Inferences and Comparisons 570
     
    35 Publication Bias 595
     
    36 Quality of Life 608
     
    37 Relative Risk Modeing 622
     
    38 Sample Size Considerations for Morbidity/Mortality Trials 633
     
    39 Sample Size for Comparing Means 642
     
    40 Sample Size for Comparing Proportions 653
     
    41 Sample Size for Comparing Time-to-Event Data 664
     
    42 Sample Size for Comparing Variabilities 672
     
    43 Screening, Models of 689
     
    44 Screening Trials 721
     
    45 Secondary Efficacy End Points 731
     
    46 Sensitivity, Specificity, and Receiver Operator Characteristic (ROC) Methods 740
     
    47 Software for Genetics/Genomics 752
     
    48 Stability Study Designs 778
     
    49 Subgroup Analysis 793
     
    50 Survival Analysis, Overview 802
     
    51 The FDA and Regulatory Issues 815
     
    52 The Kappa Index 836
     
    53 Treatment Interruption 846
     
    54 Trial Reports: Improving Reporting, Minimizing Bias, and Producing Better Evidence-Based Practice 860
     
    55 U.S. Department of Veterans Affairs Cooperative Studies Program 876
     
    56 Women's Health Initiative: Statistical Aspects and Selected Early Results 901
     
    57 World Health Organization (WHO): Global Health Situation 914
     
    Index 925