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Produktbild: Blood Science

Blood Science Principles and Pathology

138,99 €

inkl. gesetzl. MwSt., Versandkostenfrei


Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

24.03.2014

Verlag

John Wiley & Sons

Seitenzahl

556

Maße (L/B/H)

24,6/19,6/2,8 cm

Gewicht

1225 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-118-35138-3

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

24.03.2014

Verlag

John Wiley & Sons

Seitenzahl

556

Maße (L/B/H)

24,6/19,6/2,8 cm

Gewicht

1225 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-118-35138-3

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: Blood Science
  • Preface, xiii

    Acknowledgements, xv

    List of Abbreviations, xvii

    About the Companion Website, xxi

    1 Introduction to Blood Science, 1

    1.1 What is blood science?, 1

    1.2 Biochemistry, 6

    1.3 Blood transfusion, 8

    1.4 Genetics, 10

    1.5 Haematology, 14

    1.6 Immunology, 17

    1.7 The role of blood science in modern healthcare, 19

    1.8 What this book will achieve, 22

    Summary, 23

    References, 23

    Further reading, 23

    Web sites, 23

    2 Analytical Techniques in Blood Science, 25

    2.1 Venepuncture, 25

    2.2 Anticoagulants, 26

    2.3 Sample identification and tracking, 27

    2.4 Technical and analytical confidence, 27

    2.5 Major techniques, 32

    2.6 Molecular genetics, 43

    2.7 Point of care testing, 47

    2.8 Health and safety in the laboratory, 48

    Summary, 49

    Further reading, 50

    Web sites, 50

    3 The Physiology of the Red Blood Cell, 51

    3.1 Introduction, 51

    3.2 The development of blood cells, 52

    3.3 Erythropoiesis, 56

    3.4 The red cell membrane, 58

    3.5 The cytoplasm of the red cell, 60

    3.6 Oxygen transport, 66

    3.7 Recycling the red cell, 68

    3.8 Red cell indices in the full blood count, 69

    3.9 Morphology of the red cell, 72

    Summary, 74

    Further reading, 74

    4 The Pathology of the Red Blood Cell, 75

    4.1 Introduction: diseases of red cells, 75

    4.2 Anaemia resulting from attack on, or stress to, the bone marrow, 78

    4.3 Anaemia due to deficiency, 80

    4.4 Intrinsic defects in the red cell, 85

    4.5 External factors acting on healthy cells, 100

    4.6 Erythrocytosis and polycythaemia, 103

    4.7 Molecular genetics and red cell disease, 105

    4.8 Inclusion bodies, 105

    4.9 Case studies, 105

    Summary, 107

    References, 107

    Further reading, 107

    5 White Blood Cells in Health and Disease, 109

    5.1 Introduction, 109

    5.2 Leukopoiesis, 111

    5.3 Neutrophils, 115

    5.4 Lymphocytes, 116

    5.5 Monocytes, 117

    5.6 Eosinophils, 118

    5.7 Basophils, 119

    5.8 Leukocytes in action, 120

    5.9 White cells in clinical medicine, 127

    5.10 Case studies, 132

    Summary, 132

    Further reading, 133

    6 White Blood Cell Malignancy 135

    6.1 The genetic basis of leukocyte malignancy, 135

    6.2 Tissue techniques in haemato-oncology, 139

    6.3 Leukaemia, 141

    6.4 Lymphoma, 149

    6.5 Myeloma and related conditions, 152

    6.6 Myelofibrosis and myelodysplasia, 157

    6.7 Case studies, 157

    Summary, 158

    Further reading, 159

    Guidelines, 159

    7 The Physiology and Pathology of Haemostasis, 161

    7.1 The blood vessel wall, 162

    7.2 Platelets, 163

    7.3 The coagulation pathway, 165

    7.4 Haemostasis as the balance between thrombus formation and removal, 168

    7.5 The haemostasis laboratory, 171

    7.6 The pathology of thrombosis, 173

    Summary, 175

    Further reading, 175

    8 The Diagnosis and Management of Disorders of Haemostasis, 177

    8.1 Thrombosis 1: overactive platelets and thrombocytosis, 177

    8.2 Thrombosis 2: overactive coagulation, 181

    8.3 Haemorrhage 1: platelet underactivity and thrombocytopenia, 193

    8.4 Haemorrhage 2: coagulation underactivity, 199

    8.5 Disseminated intravascular coagulation, 203

    8.6 Molecular genetics in haemostasis, 204

    8.7 Case studies, 205

    Summary, 206

    References, 206

    Further reading, 207

    Guidelines, 207

    Web sites, 207

    9 Immunopathology, 209

    9.1 Introduction, 209

    9.2 Basics of the immune system, 210

    9.3 Humoral immunity, 212

    9.4 Immunopathology 1: immunodeficiency, 215

    9.5 Immunopathology 2: hypersensitivity, 221

    9.6 Immunopathology 3: autoimmune disease, 226

    9.7 Immunotherapy, 232

    9.8 The immunology laboratory, 234

    9.9 Case studies, 238

    Summary, 239

    References, 240

    Further reading, 240

    Guidelines, 240

    Web sites, 240

    10 Immunogenetics and Histocompatibility, 241

    10.1 The genetics of antigen recognition, 241

    10.2 Human leukocyte antigens, 245

    10.3 Transplantation, 251

    10.4 Autoimmunity and human leukocyte antigens, 257

    Summary, 260

    Further reading, 260

    Guidelines, 260

    Web sites, 260

    11 Blood Transfusion, 261

    11.1 Blood collection and processing, 262

    11.2 Blood groups, 265

    11.3 Laboratory practice of blood transfusion, 273

    11.4 Clinical practice of blood transfusion, 279

    11.5 Hazards of blood transfusion, 281

    Summary, 284

    References, 284

    Further reading, 284

    Guidelines, 284

    Web sites, 285

    12 Waste Products, Electrolytes and Renal Disease, 287

    12.1 Renal anatomy and physiology, 287

    12.2 Homeostasis, 288

    12.3 Excretion, 295

    12.4 Renal endocrinology, 297

    12.5 Renal disease, 298

    12.6 Case studies, 301

    Summary, 303

    Further reading, 303

    Guidelines, 303

    Web sites, 303

    13 Hydrogen Ions, pH, and Acid-Base Disorders, 305

    13.1 Ions and molecules, 305

    13.2 Blood gases, 308

    13.3 Acidosis (pH <7.3), 312

    >7.5), 313

    13.5 Mixed acid-base conditions, 314

    13.6 Clinical interpretation, 314

    13.7 Case studies, 315

    Summary, 316

    Further reading, 317

    Web site, 317

    14 Glucose, Lipids and Atherosclerosis, 319

    14.1 Glucose, 319

    14.2 Dyslipidaemia, 333

    14.3 Atherosclerosis, 343

    14.4 Case studies, 347

    Summary, 348

    Further reading, 348

    Guidelines, 349

    Web sites, 349

    15 Calcium, Phosphate, Magnesium and Bone Disease, 351

    15.1 Calcium, 352

    15.2 Phosphates, 355

    15.3 Magnesium, 355

    15.4 The laboratory, 355

    15.5 Disorders of calcium homeostasis, 357

    15.6 Disorders of phosphate homeostasis, 360

    15.7 Disorders of magnesium homeostasis, 362

    15.8 Bone physiology, 363

    15.9 Bone disease, 364

    15.10 Case studies, 368

    Summary, 369

    Further reading, 370

    Guidelines, 370

    Web sites, 370

    16 Nutrients and Gastrointestinal Disorders, 371

    16.1 Nutrients, 371

    16.2 The intestines, 375

    16.3 Case studies, 381

    Summary, 382

    Further reading, 382

    Guidelines, 382

    17 Liver Function Tests and Plasma Proteins, 383

    17.1 Anatomy and physiology of the liver, 384

    17.2 Liver function tests, 389

    17.3 Diseases of the liver, 390

    17.4 Plasma proteins, 396

    17.5 Case studies, 405

    Summary, 406

    Further reading, 406

    Web sites, 406

    18 Hormones and Endocrine Disorders, 407

    18.1 Endocrine physiology, 407

    18.2 The pathology of the endocrine system, 417

    18.3 Case studies, 434

    Summary, 435

    Further reading, 435

    Web sites, 436

    19 Cancer and Tumour Markers, 437

    19.1 General concepts in cancer biology, 437

    19.2 Blood science and cancer, 440

    19.3 Molecular genetics, 444

    19.4 Case studies, 445

    Summary, 446

    Further reading, 446

    Guidelines, 447

    Web sites, 447

    20 Inherited Metabolic Disorders, 449

    20.1 The genetics of inheritance, 449

    20.2 Molecular inherited metabolic disorders, 451

    20.3 Organelle inherited metabolic disorders, 455

    20.4 Antenatal diagnosis and neonatal screening, 455

    20.5 Case studies, 456

    Summary, 457

    Further reading, 457

    21 Drugs and Poisons, 459

    21.1 Toxicology, 459

    21.2 Toxicology of specific compounds, 461

    21.3 Therapeutic drug monitoring, 465

    21.4 Case studies, 468

    Summary, 469

    References, 469

    Further reading, 469

    22 Case Reports in Blood Science, 471

    Abbreviations, 471

    Case report 1, 472

    Anaemia, hypercalcaemia, proteinuria, myeloma
    Case report 2, 473

    Diabetes, glycated haemoglobin, chronic renal failure
    Case report 3, 474

    Acute kidney injury, leucocytosis, neutrophilia, viruses
    Case report 4, 475

    Part 1: Obesity, colorectal cancer, CEA, hypothyroidism. Part 2: Alcoholism, raised GGT and triacylglycerols
    Case report 5, 477

    Part 1: No abnormalities. Part 2: Asthma, raised IgE. Part 3: Falling haemoglobin, rising ESR, lung cancer
    Case report 6, 479

    Hypothyroidism, marginally reduced haemoglobin
    Case report 7, 480

    Raised CRP, ESR, rheumatoid factor and anti-nuclear antibodies; borderline anti-dsDNA antibodies, low C3, low eGFR and so mild renal failure, systemic lupus erythematosus
    Case report 8, 481

    Normal blood results in renal transplantation
    Case report 9, 482

    Falling albumin, eGFR, haemoglobin, red cell count and platelets, rising ESR, white cell count and neutrophila, CRP, urea and creatinine, septicaemia
    Case report 10, 484

    Microcytic anaemia, thrombocytopenia, lymphocytosis, abnormal LFTs, falling albumin, raised CRP, myositis with raised CK, viruses
    Case report 11, 486

    Acidosis, hyperglycaemia, diabetic ketoacidosis, acute renal injury, raised urea and creatinine
    Case report 12, 487

    Low haemoglobin, thrombocytopenia, raised CRP and d-dimers, abnormal LFTs, malaria, pregnancy
    Case report 13, 488

    Raised aldosterone, hypernatraemia, hypokalaemia, Conn's syndrome Case report 14, 489

    Paediatric diabetic ketoacidosis, hyperglycaemia, low bicarbonate, raised phosphates, ALP and proteins

    References, 490

    Appendix: Reference Ranges, 491

    Further Reading, 493

    Glossary, 495

    Index, 519