List of Contributors vii
Preface xii
Section I: Introduction to Liver Biology
1 Liver regeneration and fibrosis 3
Stuart J. Forbes and Malcolm R. Alison
2 Hepatic immunology 13
Gyongyi Szabo and Johanna Bruneau
Section II: Hepatitis A Virus
3 Structure, molecular virology, natural history, and experimental models 29
Gerardo G. Kaplan, Krishnamurthy Konduru, Mohanraj Manangeeswaran, Jerome Jacques, Nadia Amharref, and Siham Nakamura
4 Epidemiology and prevention 43
Benjamin Cowie and Stephen A. Locarnini
Section III: Hepatitis B Virus and Other
Hepadnaviridae
5 Structure and molecular virology 65
Souphalone Luangsay and Fabien Zoulim
6 Epidemiology and prevention 81
Philip R. Spradling, Dale J. Hu, and Brian J. McMahon
7 Other Hepadnaviridae (Avihepadnaviridae (DHBV) and Orthohepadnaviridae (WHV)) 96
Stephen A. Locarnini and Michael Roggendorf
8 Molecular variants of hepatitis B surface antigen (HBsAg) 107
Seyed Mohammad Jazayeri, Seyed Moayed Alavian, Payam Dindoost, Howard C. Thomas, and Peter Karayiannis
9 Molecular variants of the precore, core, and core promoter regions of hepatitis B virus, and theirclinical significance 127
Peter Karayiannis, William F. Carman, and Howard C. Thomas
10 Natural history of chronic hepatitis B virus infection 143
Yun-Fan Liaw
11 Extrahepatic manifestations of hepatitis B infection 154
Christian Trépo, Majid Amiri, and Loïc Guillevin
12 Hepatitis B and hepatocellular carcinoma 163
Marie Annick Buendia and Pierre Tiollais
13 Murine models and human studies of pathogenesis of chronic hepatitis B 176
Juandy Jo, Anthony Tanoto Tan, and Antonio Bertoletti
14 Treatment of hepatitis B 188
Hellan K. Kwon and Anna S.F. Lok
15 Liver transplantation for chronic hepatitis B and C 203
Ed Gane
Section IV: Hepatitis C Virus
16 Structure and molecular virology 221
Michael J. McGarvey and Michael Houghton
17 Epidemiology and prevention 246
Josep Quer and Juan I. Esteban Mur
18 The immune response to HCV in acute and chronic infection 266
Robert Thimme and Salim I. Khakoo
19 Animal models of hepatitis C virus infection 280
Patrizia Farci and Jens Bukh
20 Extrahepatic manifestations of hepatitis C virus infection 295
Benjamin Maasoumy, Michael P. Manns, and Markus Cornberg
21 Central nervous system complications of hepatitis c virus infection 310
Daniel M. Forton, Simon Taylor-Robinson, Markus Gess, and Howard C. Thomas
22 In vitro replication models 325
Volker Lohmann, Sandra Bühler, and Ralf Bartenschlager
23 Natural history of chronic HCV infection and non-invasive assessment of hepatic fibrosis 341
Laurent Castera
24 Hepatitis C and hepatocellular carcinoma 353
Hubert E. Blum
25 Treatment of hepatitis C 362
Christoph Welsch and Stefan Zeuzem
26 Development of anti-HCV drugs 377
Esperance Schaefer and Raymond T. Chung
Section V: Hepatitis D Virus
27 Structure and molecular virology 395
Francesco Negro
28 Epidemiology and natural history 403
Heiner Wedemeyer, Svenja Hardtke, and Michael P. Manns
29 Treatment of hepatitis D 410
Alessia Ciancio and Mario Rizzetto
Section VI: Hepatitis E Virus
30 Structure and molecular virology 419
Xiang-Jin Meng
31 Epidemiology, experimental models, and prevention: zoonotic aspects of hepatitis E 431
Subrat Kumar Panda and Satya Pavan Kumar Varma
32 Clinical and pathological features, and diagnosis 442
Cyril Sieberhagen and Matthew E. Cramp
Section VII: Clinical Aspects of Viral Liver Disease
33 Clinical and diagnostic aspects of viral hepatitis 453
Cui Li Lin, Chelsea Q. Xu, and Jack R. Wands
34 Treatment of acute hepatitis, severe acute hepatitis, and acute liver failure 468
Hans L. Tillmann and Alastair D. Smith
35 Hepatitis and hemophilia 486
Mike Makris and Geoffrey Dusheiko
36 Hepatitis in persons infected with HIV 494
Janice Main and Brendan McCarron
37 Migration, hepatitis B, and hepatitis C 506
Manuel Carballo, Rowan Cody, Megan Kelly and Angelos Hatzakis
38 Occupational aspects of hepatitis 515
William L. Irving and Fortune Ncube
39 Neonatal and pediatric infection 529
Deirdre A. Kelly and C.Y. William Tong
40 Management of hepatocellular carcinoma 544
Massimo Iavarone and Massimo Colombo
41 Application of molecular biology to the diagnosis of viral hepatitis 552
Stéphane Chevaliez, Christophe Rodriguez, and Jean-Michel Pawlotsky
42 Disinfection and sterilization 564
Martin S. Favero and Walter W. Bond
43 Evolution of hepatitis viruses 575
Peter Simmonds and Donald B. Smith
Index 587
