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Produktbild: Perinatal Stem Cells

Perinatal Stem Cells

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

18.03.2013

Herausgeber

Kyle Cetrulo + weitere

Verlag

John Wiley & Sons

Seitenzahl

320

Maße (L/B/H)

25,4/18,3/2,3 cm

Gewicht

726 g

Auflage

2nd Revised edition

Sprache

Englisch

ISBN

978-1-118-20944-8

Beschreibung

Rezension

"A classic text, focuses on recent research and advances in the clinical use of mesenchyme stem cells from pregnancy sources." ( Pediatric Endocrinology Reviews , 1 June 2014)

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

18.03.2013

Herausgeber

Verlag

John Wiley & Sons

Seitenzahl

320

Maße (L/B/H)

25,4/18,3/2,3 cm

Gewicht

726 g

Auflage

2nd Revised edition

Sprache

Englisch

ISBN

978-1-118-20944-8

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: GPSR Kontakt

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  • Produktbild: Perinatal Stem Cells
  • Contributors xi

    Introduction xv

    1 AMNIOTIC FLUID STEM CELLS 1
    Sean Vincent Murphy and Anthony Atala

    Introduction 1

    Development of Gestational Stem Cells 2

    Isolation and Characterization of Amniotic Fluid Stem Cells 2

    Multipotency of Amniotic Fluid Stem Cells 3

    Clinical Application of Amniotic Fluid Stem Cells 8

    Conclusion 13

    References 13

    2 CORD BLOOD TRANSPLANTS: PERINATAL STEM CELLS IN CLINICAL PRACTICE 17
    Richard L. Haspel and Karen K. Ballen

    Introduction 17

    Hematopoietic Stem Cell Transplants: Adult Donor Collection 17

    Hematopoietic Stem Cell Transplants: HLA Matching 18

    Collection and Processing of Cord Blood Units 19

    Hematopoietic Stem Cell Transplants: Recipient Issues 20

    Bone Marrow versus Single Cord Blood: Pediatric 21

    Bone Marrow versus Cord Blood: Adults 23

    Cord Blood Transplant: Advantages and Disadvantages 23

    Double Cord Blood Transplants: Ablative Regimens 24

    Double Cord Blood Transplant: Non-Myeloablative Regimens 26

    Are Two Cords Better Than One? 27

    Chimerism 28

    Predicting the Winner 28

    Other Experimental Strategies 30

    Summary 31

    References 31

    3 HEMATOPOIETIC STEM CELL DEVELOPMENT IN THE PLACENTA 37
    Katrin E.R. Ericson, Akanksha Chhabra, and Hanna K.A. Mikkola

    Introduction 37

    The Hematopoietic System 37

    Historical Perspective on Placental Hematopoiesis 38

    The Development and Structure of the Mouse Placenta 39

    Hematopoietic Activity in the Mouse Placenta 40

    Identification of Placental HSCs 42

    The Origin and Localization of Placental HSCs 43

    Hematopoietic Activity in the Human Placenta 45

    Hematopoietic Microenvironment in the Placenta 46

    Conclusions and Perspectives 47

    References 49

    4 PERINATAL MESENCHYMAL STEM CELL BANKING FOR UMBILICAL CORD BLOOD TRANSPLANTATION AND REGENERATIVE MEDICINE 53
    Rouzbeh R. Taghizadeh

    Introduction 53

    Hematopoiesis 54

    Hematopoietic Transplantations 54

    Umbilical Cord: Source of Perinatal HSCs and MSCs 56

    Hematopoietic Transplantations of Umbilical Cord Blood 57

    Strategies to Overcome the Transplant-Related Limitations of Umbilical Cord Blood 58

    Umbilical Cord Tissue MSC Banking 61

    References 63

    5 MAKING ORGAN AND STEM CELL TRANSPLANTATION SAFER: THE ROLE OF MESENCHYMAL STEM CELLS 71
    Hans Klingemann

    Introduction 71

    MSC to Prevent Rejection After Solid Organ Transplantation 72

    MSC in the Treatment of Graft-versus-Host Disease 73

    MSC to Support Hematopoietic Recovery of Stem Cells After Stem Cell Transplantation 74

    References 75

    6 WHARTON'S JELLY MESENCHYMAL STEM CELLS AND IMMUNE MODULATION: REGENERATIVE MEDICINE MEETS TISSUE REPAIR 77
    Rita Anzalone, Felicia Farina, Melania Lo Iacono, Simona Corrao, Tiziana Corsello, Giovanni Zummo, and Giampiero La Rocca

    Introduction 77

    Expression of Relevant Immunomodulatory Molecules in Vitro by MSCs 79

    Tolerance Induction by MSCs: Rediscovering the Embryo Immune Evasion Mechanisms 79

    Immune Modulation in Vivo: Contrasting Data on the Immune Privilege of MSCs 80

    WJ-MSC in in Vivo Models: Enhancing the Immunomodulatory Features of Adult MSC Populations 82

    Conclusions and Future Perspectives 83

    References 84

    7 IMMUNOGENICITY VERSUS IMMUNOMODULATION OF PERINATAL STEM CELLS 89
    Bram Lutton and Raimon Duran-Struuck

    Introduction 89

    Mechanisms of Immunomodulation by Umbilical Cord- and Bone Marrow-Derived MSCs 90

    Innate Immune System 90

    Adaptive Immune System 92

    Natural Tolerance and Umbilical Cord Tissues 94

    Tolerance versus Immunogenicity: The Yin and Yang of Host Responses to Umbilical Cord-Derived Cells 95

    Conclusions 97

    References 98

    8 THE TRANSLATIONAL POTENTIAL OF PERINATAL STEM CELLS IN CLINICAL MEDICINE: MESENCHYMAL STEM CELLS 105
    Radbeh Torabi, Vincenzo Villani, Christopher A. Mallard, and Curtis L. Cetrulo, Jr.

    Introduction 105

    Graft-versus-Host Disease 106

    Acute GVHD 107

    Chronic GVHD 108

    GVHD Prevention 109

    Hematopoetic Recovery and HCT Engraftment 109

    Hematopoietic Recovery 110

    HCT Engraftment 111

    MSC Potential Uses 111

    References 113

    9 NEWBORN STEM CELLS: IDENTITY, FUNCTION, AND CLINICAL POTENTIAL 119
    Anthony Park, Louis Chan, Mayur Danny I. Gohel, Sean Murphy, Ursula Manuelpillai, Ann Chidgey, and Richard Boyd

    Introduction 120

    The Newborn Offers an Enormous Opportunity for Stem Cells 120

    Amnion 120

    Isolation and Phenotypic Characterization of Amnion Cells 121

    Therapeutic Potential of Amnion Membrane 123

    Mechanisms of AEC-Enhanced Wound Repair 125

    Therapeutic Potential of Amnion as Single Cells 127

    Amnion Immunogenicity and Immunosuppressive Properties 127

    Amnion-Derived Mesenchymal Stromal Cells 128

    Umbilical Cord Mesenchymal Stromal Cells 130

    Chorion MSCs 131

    References 133

    10 BIOMEDICAL POTENTIAL OF HUMAN PERINATAL STEM CELLS 139
    Oleg V. Semenov and Christian Breymann

    Role of Stem Cells in Regenerative Medicine 139

    Perinatal Stem Cell Sources 140

    Properties of Perinatal Mesenchymal Stem Cells 143

    Properties of Perinatal Hematopoietic Stem Cells 144

    Biomedical Applications of Human Perinatal Stem Cells 145

    Perspectives and Obstacles 147

    References 148

    11 PROGENITOR CELL THERAPY FOR THE TREATMENT OF TRAUMATIC BRAIN INJURY 155
    Alex Bryan Olsen, Robert A. Hetz, Supinder S. Bedi, and Charles S. Cox, Jr.

    Introduction 155

    Cellular Therapy for the Treatment of TBI 159

    Neural Stem Progenitor Cells 159

    Human Multipotent Adult Progenitor Cells 160

    Mesenchymal Stem Cells 163

    Umbilical Cord Blood 165

    Wharton's Jelly 166

    Amniotic Fluid-Derived Stem Cells 167

    The Inflammatory Reflex 168

    Conclusion 170

    References 171

    12 THE HUMAN AMNIOTIC MEMBRANE: A TISSUE WITH MULTIFACETED PROPERTIES AND DIFFERENT POTENTIAL CLINICAL APPLICATIONS 177
    Maddalena Caruso, Antonietta Silini, and Ornella Parolini

    Introduction 177

    Structure and Histology of the Human Amniotic Membrane 178

    Preparation, Preservation, and Sterilization of the Human Amniotic Membrane 179

    Biological and Structural Properties of the Human Amniotic Membrane Generally Invoked to Explain Its Effects in Vivo 180

    Established Clinical Applications of the Human Amniotic Membrane 183

    Prospective Applications of the Human Amniotic Membrane: Lessons from Preclinical Studies 187

    Conclusions and Perspectives 190

    References 190

    13 ADVANCES AND POSSIBLE APPLICATIONS OF HUMAN AMNION FOR THE MANAGEMENT OF LIVER DISEASE 197
    Fabio Marongiu, Maria Paola Serra, Marcella Sini, Ezio Laconi, Marc C. Hansel, Kristen J. Skvorak, Roberto Gramignoli, and Stephen C. Strom

    Introduction 197

    Human Amnion for the Management of Liver Fibrosis 198

    Amnion-Derived Hepatocytes and Their Possible Applications 199

    Conclusions 204

    References 205

    14 AMNION-DERIVED CELLS FOR STROKE RESTORATIVE THERAPY 209
    Naoki Tajiri, Loren E. Glover, and Cesar V. Borlongan

    Introduction 209

    Stem Cell Therapy: Beyond Stroke Neuroprotection 210

    Therapeutic Potential of Adult Stem Cells 210

    The Biology of Amnion-Derived Cells 211

    Amnion-Derived Cells for Cell Therapy 212

    Conclusion 215

    References 216

    15 PREGNANCY-ACQUIRED FETAL PROGENITORS AS NATURAL CELL THERAPY 221
    Elke Seppanen, Nicholas M. Fisk,and Kiarash Khosrotehrani

    Introduction 221

    Fetal Cell Microchimerism, a Widespread Phenomenon 222

    The Kinetics of Fetal Cell Detection 222

    Factors Modifying the Level of Microchimerism 222

    Detecting FMC 223

    Homing and Plasticity of FMC 224

    Hematopoietic Capacity of FMC 224

    Epithelial, Neuronal and Hepatic Capacity of FMC 228

    Mesenchymal Capacity of FMC 228

    FMC Includes Functional Endothelial Progenitor Cells that Contribute to Tissue Repair 229

    FMC Likely Includes Cells of Placental Origin 230

    Conclusions 230

    References 231

    INDUSTRY REVIEW 235

    16 PERINATAL STEM CELLS: AN INDUSTRY PERSPECTIVE 237
    Kyle J. Cetrulo

    Introduction 237

    The Public Cord Blood Banking Industry 238

    The Private Banking Industry 239

    Research and Cord Blood Clinical Trials 240

    The Mesenchymal Stem Cell Regenerative Medicine Industry 241

    Wharton's Jelly/Cord Tissue 242

    Placental Stem Cells and Placental Tissue 243

    Amniotic Fluid 244

    Conclusion 245

    References 245

    17 PATENT PROTECTION OF STEM CELL INNOVATIONS 249
    John R. Wetherell

    The Role of Patents in Commercialization 249

    Background of the Patent System 250

    Patentable Subject Matter 251

    Statutory Requirements for a Patent 252

    Written Description/Enablement/Best Mode 254

    Important Future Changes 256

    18 INTERVIEW WITH FRANCES VERTER, FOUNDER OF PARENT'S GUIDE TO CORD BLOOD FOUNDATION 259
    Frances Verter and Kyle J. Cetrulo

    References 269

    19 UMBILICAL CORD BLOOD BANKING: AN OBSTETRICIAN'S PERSPECTIVE 271
    Jordan H. Perlow

    References 277

    Index 279