List of Contributors xvii
 
Foreword xxiii
Mar1a Jose Alonso
 
Preface xxv
 
Acknowledgments xxvii
 
Part One General Aspects of Chitosan 1
 
1 Chemical and Technological Advances in Chitins and Chitosans Useful for the Formulation of Biopharmaceuticals 3
Riccardo A. A. Muzzarelli
 
2 Physical Properties of Chitosan and Derivatives in Sol and Gel States 23
Marguerite Rinaudo
 
3 Absorption Promotion Properties of Chitosan and Derivatives 45
Akira Yamamoto
 
4 Biocompatibility and Biodegradation of Chitosan and Derivatives 57
Ahmad Sukari Halim, Lim Chin Keong, Ismail Zainol, and Ahmad Hazri Abdul Rashid
 
5 Biological and Pharmacological Activity of Chitosan and Derivatives 75
Teresa Cunha, Branca Teixeira, Barbara Santos, Marlene Almeida, Gustavo Dias, and Jose das Neves
 
6 Biological, Chemical, and Physical Compatibility of Chitosan and Biopharmaceuticals 93
Masayuki Ishihara, Masanori Fujita, Satoko Kishimoto, Hidemi Hattori, and Yasuhiro Kanatani
 
7 Approaches for Functional Modification or Cross-Linking of Chitosan 107
A. Anitha, N. Sanoj Rejinold, Joel D. Bumgardner, Shanti V. Nair, and Rangasamy Jayakumar
 
Part Two Biopharmaceuticals Formulation and Delivery Aspects Using Chitosan and Derivatives 125
 
8 Use of Chitosan and Derivatives in Conventional Biopharmaceutical Dosage Forms Formulation 127
Teofilo Vasconcelos, Pedro Barrocas, and Rui Cerdeira
 
9 Manufacture Techniques of Chitosan-Based Microparticles and Nanoparticles for Biopharmaceuticals 137
Franca Ferrari, M. Cristina Bonferoni, Silvia Rossi, Giuseppina Sandri, and Carla M. Caramella
 
10 Chitosan and Derivatives for Biopharmaceutical Use: Mucoadhesive Properties 159
Katharina Leithner and Andreas Bernkop-Schnurch
 
11 Chitosan-Based Systems for Mucosal Delivery of Biopharmaceuticals 181
Sonia Al-Qadi, Ana Grenha, and Carmen Remunan-Lopez
 
12 Chitosan-Based Delivery Systems for Mucosal Vaccination 211
Gerrit Borchard, Farnaz Esmaeili, and Simon Heuking
 
13 Chitosan-Based Nanoparticulates for Oral Delivery of Biopharmaceuticals 225
Filipa Antunes, Fernanda Andrade, and Bruno Sarmento
 
14 Chitosan-Based Systems for Ocular Delivery of Biopharmaceuticals 243
Suresh P. Vyas, Rishi Paliwal, and Shivani Rai Paliwal
 
15 Chemical Modification of Chitosan for Delivery of DNA and siRNA 255
You-Kyoung Kim, Hu-Lin Jiang, Ding-Ding Guo, Yun-Jaie Choi, Myung-Haing Cho, Toshihiro Akaike, and Chong-Su Cho
 
Part Three Advanced Application of Chitosan and Derivatives for Biopharmaceuticals 275
 
16 Target-Specific Chitosan-Based Nanoparticle Systems for Nucleic Acid Delivery 277
Shardool Jain and Mansoor Amiji
 
17 Functional PEGylated Chitosan Systems for Biopharmaceuticals 301
Hee-Jeong Cho, Goen Kim, Hyeok-Seung Kwon, and Yu-Kyoung Oh
 
18 Stimuli-Sensitive Chitosan-Based Systems for Biopharmaceuticals 319
Cuiping Zhai, Jinfang Yuan, and Qingyu Gao
 
19 Chitosan Copolymers for Biopharmaceuticals 333
Ramon Novoa-Carballal, Ricardo Riguera, and Eduardo Fernandez-Megia
 
20 Application of Chitosan for Anticancer Biopharmaceutical Delivery 381
Claudia Philippi, Brigitta Loretz, Ulrich F. Schaefer, and Claus-Michael Lehr
 
21 Chitosan-Based Biopharmaceutical Scaffolds in Tissue Engineering and Regenerative Medicine 393
Tao Jiang, Meng Deng, Wafa I. Abdel- Fattah, and Cato T. Laurencin
 
22 Wound-Healing Properties of Chitosan and Its Use in Wound Dressing Biopharmaceuticals 429
Tyler G. St. Denis, Tianhong Dai, Ying-Ying Huang, and Michael R. Hamblin
 
Part Four Regulatory Status, Toxicological Issues, and Clinical Perspectives 451
 
23 Toxicological Properties of Chitosan and D