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Cell-Penetrating Peptides Methods and Protocols

Aus der Reihe Methods in Molecular Biology
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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

08.11.2010

Herausgeber

Ülo Langel

Verlag

Humana Press

Seitenzahl

586

Maße (L/B/H)

26/18,3/3,7 cm

Gewicht

1317 g

Auflage

2011

Sprache

Englisch

ISBN

978-1-60761-918-5

Beschreibung

Rezension

From the reviews:

“Prof. Ulo Langel … rightly explain in a necessary preface that there are in use so many definition for the same things: protein transduction domain (PTDs), Trojan peptides, model amphipathic peptides (MAPs), membrane translocating sequences (MTS) that the best way to refer to all of these molecules is to call all of them cell-penetrating peptides, CPPs. … Clearly enough, the cell-penetrating peptides volume is surely of great help for basic research and for clinicians engaged in translational medicine.” (Carlo Alberto Redi, European Journal of Histochemistry, Vol. 55, 2011)

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

08.11.2010

Herausgeber

Ülo Langel

Verlag

Humana Press

Seitenzahl

586

Maße (L/B/H)

26/18,3/3,7 cm

Gewicht

1317 g

Auflage

2011

Sprache

Englisch

ISBN

978-1-60761-918-5

Herstelleradresse

Springer-Verlag GmbH
Tiergartenstr. 17
69121 Heidelberg
DE

Email: ProductSafety@springernature.com

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  • Produktbild: Cell-Penetrating Peptides
  • Cell-penetrating Peptides. Methods and Protocols.
    Űlo Langel, Editor
    Table of Contents:

    Table of Contents

    Preface

    Contributors

    Part I. Introduction
    1. Classes and prediction of cell-penetrating peptides
    Maria Lindgren and Ülo Langel

    2. Penetratin story : an overview
    Edmond Dupont, Alain Prochiantz and Alain Joliot

    Part II. Methods to test mechanisms of cell-penetrating peptides
    3. Testing membrane interactions of CPPs
    Astrid Gräslund and Lena Mäler

    4. Interactions of amphipathic CPPs with model membranes
    Sébastien Deshayes, Karidia Konate, Gudrun Aldrian, Frédéric Heitz, and Gilles Divita

    5. NMR studies of three-dimensional structure and positioning of CPPs in membrane model systems
    Lena Mäler and Astrid Gräslund

    6. Measurements of the intracellular stability of CPPs
    Ivo R. Ruttekolk, Wouter P. R. Verdurmen, Yi-Da Chung, and Roland Brock

    7. Tools for predicting binding and insertion of CPPs into lipid bilayers
    Paulo Almeida

    8. Studies of proteoglycan involvement in CPP-mediated delivery
    Anders Wittrup, Si-He Zhang and Mattias Belting

    9. Uptake Kinetics of cell-penetrating peptides
    Anders Florén, Imre Mäger, and Ülo Langel

    10. Thermodynamics of lipid interactions with cell-penetrating peptides
    Reto Sauder, Joachim Seelig and André Ziegler

    11. Calcium and membrane repair
    Caroline Palm-Apergi, and Mattias Hällbrink

    12. Mapping of protein transduction pathways with fluorescent microscopy
    Helin Räägel, Pille Säälik, Ülo Langel, and Margus Pooga

    13. Insight into cell-entry mechanisms of CPPs by electron microscopy
    Kärt Padari, Annely Lorents, Eija Jokitalo and Margus Pooga

    14. Toxicity methods for CPPs
    Per Lundin, Samir EL Andaloussi and Ülo Langel

    15. Comparison of CPP uptake methods
    Tina Holm, Samir EL Andaloussi, and Ülo Langel

    16. Characterization of cellular internalization pathways for CPP-mediated oligonucleotide delivery
    Peter Guterstam, Samir EL Andaloussi and Ülo Langel

    Part III. Functionality and cell-penetrating peptides
    17. Mimicry of protein function with cell-penetrating peptides
    Henrik Johansson, Samir EL Andaloussi and Ülo Langel

    18. Homeoprotein intercellular transfer, the hidden face of cell-penetrating peptides
    Alain Prochiantz

    19. Pharmacology, biodistribution, and efficacy of GPCR-based pepducins in disease models
    Sarah L. Tressel, Georgios Koukos, Boris Tchernychev, Suzanne L. Jacques, Lidija Covic, Athan Kuliopulos

    20. Identification and Characterization of Tissue-Specific Protein Transduction Domains using Peptide Phage Display
    Maliha Zahid, and Paul D. Robbins

    21. Applications of Cell Penetrating Peptides as Signal Transduction Modulators for the Selective Induction of Apoptosis
    Sarah Jones and John Howl

    Part IV. Applications of CPPs in gene modulation
    22. Splice Redirection as a Convenient Assay to Monitor CPP-ON Efficiency and Mechanism
    Rachida Abes, Andrey A. Arzumanov, Amer F. Saleh, Fatouma Said Hassane, Michael J. Gait and Bernard Lebleu

    23. CPP directed oligonucleotide exon skipping in animal models of Duchenne muscular
    dystrophy
    HaiFang Yin, Hong Moulton, Corinne Betts and Matthew Wood

    24. PTD-DRBD siRNA delivery
    Caroline Palm-Apergi, Akiko Eguchi, and Steven F. Dowdy

    25. A non-covalent peptide-based strategy for siRNA delivery
    Laurence Crombez, and Gilles Divita

    26. Application of PepFect peptides for the delivery of splice correcting oligonucleotides
    Samir EL Andaloussi, Taavi Lehto, Per Lundin, and Ülo Langel

    27. Internalization of nucleoside phosphates into live cells by complex formation with
    different CPPs and JBS-Nucleoducin
    Franziska Mussbach, Regina Pietrucha, Buerk Schaefer and Siegmund Reissmann

    28. Enhanced cellular delivery of cell-penetrating peptide –peptide nucleic acid conjugates by photochemical internalization (PCI).
    Takehiko Shiraishi, and Peter E. Nielsen

    Part V. CPP in vivo and as future drugs
    29. Identification of homing peptides using the in vivo phage display technology
    Antti Rivinoja and Pirjo Laakkonen

    30. Measuring the action of CPP-siRNA conjugates in the lung
    Sterghios A. Moschos, Karen G. Spink, and Mark A. Lindsay

    31. Intracellular delivery of nanoparticles with CPPs
    Rupa Sawant, Vladimir Torchilin

    32. Multifunctional CPP polymer system for tumor-targeted pDNA and siRNA delivery
    Christian Dohmen, Ernst Wagner

    33. Cell Penetrating Penta-Peptides (CPP5s) and Bax Inhibiting Peptides (BIPs): Protocol for their application
    Jose Gomez and Shigemi Matsuyama

    34. PAIR technology: exon-specific RNA binding protein isolation in live cells
    Thomas J. Bell, Emelía Eiríksdóttir, Ülo Langel and James Eberwine

    35. Quantitation of cellular and topical uptake of luciferin oligoarginine conjugates
    Jonathan B. Rothbard and Lisa R. Jones

    36. Industrial-scale manufacturing of a possible oligonucleotide cargo CPP based drug
    Ulf Tedebark, Anthony Scozzari, Oleg Werbitzky, Daniel Capaldi and Lars Holmberg

    37. Application of a fusiogenic peptide GALA for intracellular delivery
    Ikuhiko Nakase, Kentaro Kogure, Hideyoshi Harashima, Shiroh Futaki

    38. Therapeutic Applications of Cell-Penetrating Peptides
    Randolph M. Johnson, Stephen D. Harrison and Derek Maclean

    39. Nonclinical and clinical experiences with CPP-based self assembling peptide systems in
    topical drug development
    Jacob M. Waugh, Jane Lee, Michael D. Dake and Dan Browne