Therapeutic Monoclonal Antibodies (eBook, PDF)
From Bench to Clinic
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Therapeutic Monoclonal Antibodies (eBook, PDF)
From Bench to Clinic
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* 70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. * First book to address the discovery and development of antibody therapeutics in their entirety. * Most chapters contain experimental data to illustrate the principles described in them. * Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.
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* 70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. * First book to address the discovery and development of antibody therapeutics in their entirety. * Most chapters contain experimental data to illustrate the principles described in them. * Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.
Produktdetails
- Produktdetails
- Verlag: John Wiley & Sons
- Seitenzahl: 912
- Erscheinungstermin: 19. November 2009
- Englisch
- ISBN-13: 9780470485262
- Artikelnr.: 37293115
- Verlag: John Wiley & Sons
- Seitenzahl: 912
- Erscheinungstermin: 19. November 2009
- Englisch
- ISBN-13: 9780470485262
- Artikelnr.: 37293115
ZHIQIANG AN, PHD, is the Chief Scientific Officer of Epitomics, Inc., in Burlingame, California. Previously, he was Director of Biologics Research at Merck Research Laboratories, West Point, Pennsylvania. Dr. An started his biotech/pharmaceutical career at Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts. He received a doctor of philosophy degree from the University of Kentucky, Lexington, followed by postdoctoral training at the University of Wisconsin-Madison.
FOREWORD. PREFACE. CONTRIBUTORS. PART I ANTIBODY BASICS. 1. Therapeutic
Monoclonal Antibodies: Past, Present, and Future (William R. Strohl). 2.
Antibody Molecular Structure (Robyn L. Stanfield and Ian A. Wilson). 3.
Glycosylation of Therapeutic IgGs (Yusuke Mimura, Roy Jefferis, Yuka
Mimura-Kimura, Jodie Abrahams, and Pauline M. Rudd). 4. Antibody Databases
and Tools: The IMGT(r) Experience (Marie-Paule Lefranc). PART II ANTIBODY
SOURCES. 5. Human Antibodies from Transgenic Mice (Nils Lonberg). 6. Rabbit
Hybridoma (Weimin Zhu and Guo-Liang Yu). 7. Human Antibody Repertoire
Libraries (David Lowe and Tristan J. Vaughan). PART III IN VITRO DISPLAY
TECHNOLOGY. 8. Antibody Phage Display (Michael Hust, Holger Thie, Thomas
Schirrmann, and Stefan Dübel). 9. Yeast Surface Display (Jennifer L. Lahti
and Jennifer R. Cochran). 10. Ribosomal Display (George Thom). 11.
Bacterial Display of Antibodies (Thomas J. Van Blarcom and Barrett R.
Harvey). 12. Antibody Selection from Immunoglobulin Libraries Expressed in
Mammalian Cells (Ernest S. Smith and Maurice Zauderer). PART IV ANTIBODY
ENGINEERING. 13. Antibody Engineering: Humanization, Affinity Maturation,
and Selection Techniques (Juan C. Almagro and William R. Strohl). 14.
Modulation of Serum Protein Homeostasis and Transcytosis by the Neonatal Fc
Receptor (William F. Dall'Acqua and Herren Wu). 15. Engineering the
Antibody Fc Region for Optimal Effector Function (Greg A. Lazar and John R.
Desjarlais). PART V PHYSIOLOGY AND IN VIVO BIOLOGY. 16. Antibody-Complement
Interaction (Kileen L. Mershon and Sherie L. Morrison). 17. Bacteria
Immunoglobulin-Binding Proteins: Biology and Practical Applications (Leslie
Cope and Tessie McNeely). 18. Immunogenicity Screening Using in Silico
Methods: Correlation between T-Cell Epitope Content and Clinical
Immunogenicity of Monoclonal Antibodies (Si-Han Hai, Julie A. McMurry, Paul
M. Knopf, William Martin, and Anne S. De Groot). 19. Monoclonal Antibody
Pharmacokinetics and Pharmacodynamics (Christopher R. Gibson, Punam Sandhu,
and William D. Hanley). 20. Biodistribution and Imaging (Tove Olafsen and
Anna M. Wu). 21. Antibodies and the Blood-Brain Barrier (Angela R. Jones
and Eric V. Shusta). PART VI ANTIBODY CHARACTERIZATION. 22. Determination
of Equilibrium Dissociation Constants (Robin E. Ernst, Katrina N. High, Tom
R. Glass, and Qinjian Zhao). 23. Molecular and Functional Characterization
of Monoclonal Antibodies (Qinjian Zhao, Terrance A. Stadheim, Lorenzo Chen,
and Michael W. Washabaugh). 24. Characterization of Heterogeneity in
Monoclonal Antibody Products (Yang Wang, Michael W. Washabaugh, and Qinjian
Zhao). PART VII ANTIBODY EXPRESSION. 25. Antibody Expression in Mammalian
Cells (Fubao Wang, Lorenzo Chen, Neal Connors, and Henryk Mach). 26.
Production of Antibodies in Pichia pastoris (Juergen H. Nett). 27.
Production of Antibody Fab Fragments in E. coli (David P. Humphreys and
Leigh Bowering). 28. Production of Human Therapeutic Monoclonal Antibodies
in Chicken Eggs (Lei Zhu and Robert J. Etches). 29. Production of
Antibodies in Plants (Kevin M. Cox, Jeffrey T. Regan, Jason D. Sterling,
Vincent P. M. Wingate, and Lynn F. Dickey). PART VIII THERAPEUTIC
ANTIBODIES. 30. The Formulation and Delivery of Monoclonal Antibodies
(Vikas K. Sharma, Hung-Wei Chih, Randall J. Mrsny, and Ann L. Daugherty).
31. Therapeutic Antibodies in Clinical Use and Leading Clinical Candidates
(Ningyan Zhang, Brent R. Williams, Ping Lu, Zhiqiang An, and Chen-Ni Chin).
32. Follow-On Protein Products: What, Where, When, How? (Brent R. Williams
and William R. Strohl). 33. Monomeric Fc Fusion Molecules (Jennifer A.
Dumont, Susan C. Low, Robert T. Peters, and Alan J. Bitonti). 34.
Radioimmunotherapy: Current Status and Future Directions (Neeta
Pandit-Taskar and Chaitanya R. Divgi). 35. Antibody-Drug Conjugate Therapy
(Stephen C. Alley, Dennis Benjamin, and Che-Leung Law). ABBREVIATIONS.
INDEX.
Monoclonal Antibodies: Past, Present, and Future (William R. Strohl). 2.
Antibody Molecular Structure (Robyn L. Stanfield and Ian A. Wilson). 3.
Glycosylation of Therapeutic IgGs (Yusuke Mimura, Roy Jefferis, Yuka
Mimura-Kimura, Jodie Abrahams, and Pauline M. Rudd). 4. Antibody Databases
and Tools: The IMGT(r) Experience (Marie-Paule Lefranc). PART II ANTIBODY
SOURCES. 5. Human Antibodies from Transgenic Mice (Nils Lonberg). 6. Rabbit
Hybridoma (Weimin Zhu and Guo-Liang Yu). 7. Human Antibody Repertoire
Libraries (David Lowe and Tristan J. Vaughan). PART III IN VITRO DISPLAY
TECHNOLOGY. 8. Antibody Phage Display (Michael Hust, Holger Thie, Thomas
Schirrmann, and Stefan Dübel). 9. Yeast Surface Display (Jennifer L. Lahti
and Jennifer R. Cochran). 10. Ribosomal Display (George Thom). 11.
Bacterial Display of Antibodies (Thomas J. Van Blarcom and Barrett R.
Harvey). 12. Antibody Selection from Immunoglobulin Libraries Expressed in
Mammalian Cells (Ernest S. Smith and Maurice Zauderer). PART IV ANTIBODY
ENGINEERING. 13. Antibody Engineering: Humanization, Affinity Maturation,
and Selection Techniques (Juan C. Almagro and William R. Strohl). 14.
Modulation of Serum Protein Homeostasis and Transcytosis by the Neonatal Fc
Receptor (William F. Dall'Acqua and Herren Wu). 15. Engineering the
Antibody Fc Region for Optimal Effector Function (Greg A. Lazar and John R.
Desjarlais). PART V PHYSIOLOGY AND IN VIVO BIOLOGY. 16. Antibody-Complement
Interaction (Kileen L. Mershon and Sherie L. Morrison). 17. Bacteria
Immunoglobulin-Binding Proteins: Biology and Practical Applications (Leslie
Cope and Tessie McNeely). 18. Immunogenicity Screening Using in Silico
Methods: Correlation between T-Cell Epitope Content and Clinical
Immunogenicity of Monoclonal Antibodies (Si-Han Hai, Julie A. McMurry, Paul
M. Knopf, William Martin, and Anne S. De Groot). 19. Monoclonal Antibody
Pharmacokinetics and Pharmacodynamics (Christopher R. Gibson, Punam Sandhu,
and William D. Hanley). 20. Biodistribution and Imaging (Tove Olafsen and
Anna M. Wu). 21. Antibodies and the Blood-Brain Barrier (Angela R. Jones
and Eric V. Shusta). PART VI ANTIBODY CHARACTERIZATION. 22. Determination
of Equilibrium Dissociation Constants (Robin E. Ernst, Katrina N. High, Tom
R. Glass, and Qinjian Zhao). 23. Molecular and Functional Characterization
of Monoclonal Antibodies (Qinjian Zhao, Terrance A. Stadheim, Lorenzo Chen,
and Michael W. Washabaugh). 24. Characterization of Heterogeneity in
Monoclonal Antibody Products (Yang Wang, Michael W. Washabaugh, and Qinjian
Zhao). PART VII ANTIBODY EXPRESSION. 25. Antibody Expression in Mammalian
Cells (Fubao Wang, Lorenzo Chen, Neal Connors, and Henryk Mach). 26.
Production of Antibodies in Pichia pastoris (Juergen H. Nett). 27.
Production of Antibody Fab Fragments in E. coli (David P. Humphreys and
Leigh Bowering). 28. Production of Human Therapeutic Monoclonal Antibodies
in Chicken Eggs (Lei Zhu and Robert J. Etches). 29. Production of
Antibodies in Plants (Kevin M. Cox, Jeffrey T. Regan, Jason D. Sterling,
Vincent P. M. Wingate, and Lynn F. Dickey). PART VIII THERAPEUTIC
ANTIBODIES. 30. The Formulation and Delivery of Monoclonal Antibodies
(Vikas K. Sharma, Hung-Wei Chih, Randall J. Mrsny, and Ann L. Daugherty).
31. Therapeutic Antibodies in Clinical Use and Leading Clinical Candidates
(Ningyan Zhang, Brent R. Williams, Ping Lu, Zhiqiang An, and Chen-Ni Chin).
32. Follow-On Protein Products: What, Where, When, How? (Brent R. Williams
and William R. Strohl). 33. Monomeric Fc Fusion Molecules (Jennifer A.
Dumont, Susan C. Low, Robert T. Peters, and Alan J. Bitonti). 34.
Radioimmunotherapy: Current Status and Future Directions (Neeta
Pandit-Taskar and Chaitanya R. Divgi). 35. Antibody-Drug Conjugate Therapy
(Stephen C. Alley, Dennis Benjamin, and Che-Leung Law). ABBREVIATIONS.
INDEX.
FOREWORD. PREFACE. CONTRIBUTORS. PART I ANTIBODY BASICS. 1. Therapeutic
Monoclonal Antibodies: Past, Present, and Future (William R. Strohl). 2.
Antibody Molecular Structure (Robyn L. Stanfield and Ian A. Wilson). 3.
Glycosylation of Therapeutic IgGs (Yusuke Mimura, Roy Jefferis, Yuka
Mimura-Kimura, Jodie Abrahams, and Pauline M. Rudd). 4. Antibody Databases
and Tools: The IMGT(r) Experience (Marie-Paule Lefranc). PART II ANTIBODY
SOURCES. 5. Human Antibodies from Transgenic Mice (Nils Lonberg). 6. Rabbit
Hybridoma (Weimin Zhu and Guo-Liang Yu). 7. Human Antibody Repertoire
Libraries (David Lowe and Tristan J. Vaughan). PART III IN VITRO DISPLAY
TECHNOLOGY. 8. Antibody Phage Display (Michael Hust, Holger Thie, Thomas
Schirrmann, and Stefan Dübel). 9. Yeast Surface Display (Jennifer L. Lahti
and Jennifer R. Cochran). 10. Ribosomal Display (George Thom). 11.
Bacterial Display of Antibodies (Thomas J. Van Blarcom and Barrett R.
Harvey). 12. Antibody Selection from Immunoglobulin Libraries Expressed in
Mammalian Cells (Ernest S. Smith and Maurice Zauderer). PART IV ANTIBODY
ENGINEERING. 13. Antibody Engineering: Humanization, Affinity Maturation,
and Selection Techniques (Juan C. Almagro and William R. Strohl). 14.
Modulation of Serum Protein Homeostasis and Transcytosis by the Neonatal Fc
Receptor (William F. Dall'Acqua and Herren Wu). 15. Engineering the
Antibody Fc Region for Optimal Effector Function (Greg A. Lazar and John R.
Desjarlais). PART V PHYSIOLOGY AND IN VIVO BIOLOGY. 16. Antibody-Complement
Interaction (Kileen L. Mershon and Sherie L. Morrison). 17. Bacteria
Immunoglobulin-Binding Proteins: Biology and Practical Applications (Leslie
Cope and Tessie McNeely). 18. Immunogenicity Screening Using in Silico
Methods: Correlation between T-Cell Epitope Content and Clinical
Immunogenicity of Monoclonal Antibodies (Si-Han Hai, Julie A. McMurry, Paul
M. Knopf, William Martin, and Anne S. De Groot). 19. Monoclonal Antibody
Pharmacokinetics and Pharmacodynamics (Christopher R. Gibson, Punam Sandhu,
and William D. Hanley). 20. Biodistribution and Imaging (Tove Olafsen and
Anna M. Wu). 21. Antibodies and the Blood-Brain Barrier (Angela R. Jones
and Eric V. Shusta). PART VI ANTIBODY CHARACTERIZATION. 22. Determination
of Equilibrium Dissociation Constants (Robin E. Ernst, Katrina N. High, Tom
R. Glass, and Qinjian Zhao). 23. Molecular and Functional Characterization
of Monoclonal Antibodies (Qinjian Zhao, Terrance A. Stadheim, Lorenzo Chen,
and Michael W. Washabaugh). 24. Characterization of Heterogeneity in
Monoclonal Antibody Products (Yang Wang, Michael W. Washabaugh, and Qinjian
Zhao). PART VII ANTIBODY EXPRESSION. 25. Antibody Expression in Mammalian
Cells (Fubao Wang, Lorenzo Chen, Neal Connors, and Henryk Mach). 26.
Production of Antibodies in Pichia pastoris (Juergen H. Nett). 27.
Production of Antibody Fab Fragments in E. coli (David P. Humphreys and
Leigh Bowering). 28. Production of Human Therapeutic Monoclonal Antibodies
in Chicken Eggs (Lei Zhu and Robert J. Etches). 29. Production of
Antibodies in Plants (Kevin M. Cox, Jeffrey T. Regan, Jason D. Sterling,
Vincent P. M. Wingate, and Lynn F. Dickey). PART VIII THERAPEUTIC
ANTIBODIES. 30. The Formulation and Delivery of Monoclonal Antibodies
(Vikas K. Sharma, Hung-Wei Chih, Randall J. Mrsny, and Ann L. Daugherty).
31. Therapeutic Antibodies in Clinical Use and Leading Clinical Candidates
(Ningyan Zhang, Brent R. Williams, Ping Lu, Zhiqiang An, and Chen-Ni Chin).
32. Follow-On Protein Products: What, Where, When, How? (Brent R. Williams
and William R. Strohl). 33. Monomeric Fc Fusion Molecules (Jennifer A.
Dumont, Susan C. Low, Robert T. Peters, and Alan J. Bitonti). 34.
Radioimmunotherapy: Current Status and Future Directions (Neeta
Pandit-Taskar and Chaitanya R. Divgi). 35. Antibody-Drug Conjugate Therapy
(Stephen C. Alley, Dennis Benjamin, and Che-Leung Law). ABBREVIATIONS.
INDEX.
Monoclonal Antibodies: Past, Present, and Future (William R. Strohl). 2.
Antibody Molecular Structure (Robyn L. Stanfield and Ian A. Wilson). 3.
Glycosylation of Therapeutic IgGs (Yusuke Mimura, Roy Jefferis, Yuka
Mimura-Kimura, Jodie Abrahams, and Pauline M. Rudd). 4. Antibody Databases
and Tools: The IMGT(r) Experience (Marie-Paule Lefranc). PART II ANTIBODY
SOURCES. 5. Human Antibodies from Transgenic Mice (Nils Lonberg). 6. Rabbit
Hybridoma (Weimin Zhu and Guo-Liang Yu). 7. Human Antibody Repertoire
Libraries (David Lowe and Tristan J. Vaughan). PART III IN VITRO DISPLAY
TECHNOLOGY. 8. Antibody Phage Display (Michael Hust, Holger Thie, Thomas
Schirrmann, and Stefan Dübel). 9. Yeast Surface Display (Jennifer L. Lahti
and Jennifer R. Cochran). 10. Ribosomal Display (George Thom). 11.
Bacterial Display of Antibodies (Thomas J. Van Blarcom and Barrett R.
Harvey). 12. Antibody Selection from Immunoglobulin Libraries Expressed in
Mammalian Cells (Ernest S. Smith and Maurice Zauderer). PART IV ANTIBODY
ENGINEERING. 13. Antibody Engineering: Humanization, Affinity Maturation,
and Selection Techniques (Juan C. Almagro and William R. Strohl). 14.
Modulation of Serum Protein Homeostasis and Transcytosis by the Neonatal Fc
Receptor (William F. Dall'Acqua and Herren Wu). 15. Engineering the
Antibody Fc Region for Optimal Effector Function (Greg A. Lazar and John R.
Desjarlais). PART V PHYSIOLOGY AND IN VIVO BIOLOGY. 16. Antibody-Complement
Interaction (Kileen L. Mershon and Sherie L. Morrison). 17. Bacteria
Immunoglobulin-Binding Proteins: Biology and Practical Applications (Leslie
Cope and Tessie McNeely). 18. Immunogenicity Screening Using in Silico
Methods: Correlation between T-Cell Epitope Content and Clinical
Immunogenicity of Monoclonal Antibodies (Si-Han Hai, Julie A. McMurry, Paul
M. Knopf, William Martin, and Anne S. De Groot). 19. Monoclonal Antibody
Pharmacokinetics and Pharmacodynamics (Christopher R. Gibson, Punam Sandhu,
and William D. Hanley). 20. Biodistribution and Imaging (Tove Olafsen and
Anna M. Wu). 21. Antibodies and the Blood-Brain Barrier (Angela R. Jones
and Eric V. Shusta). PART VI ANTIBODY CHARACTERIZATION. 22. Determination
of Equilibrium Dissociation Constants (Robin E. Ernst, Katrina N. High, Tom
R. Glass, and Qinjian Zhao). 23. Molecular and Functional Characterization
of Monoclonal Antibodies (Qinjian Zhao, Terrance A. Stadheim, Lorenzo Chen,
and Michael W. Washabaugh). 24. Characterization of Heterogeneity in
Monoclonal Antibody Products (Yang Wang, Michael W. Washabaugh, and Qinjian
Zhao). PART VII ANTIBODY EXPRESSION. 25. Antibody Expression in Mammalian
Cells (Fubao Wang, Lorenzo Chen, Neal Connors, and Henryk Mach). 26.
Production of Antibodies in Pichia pastoris (Juergen H. Nett). 27.
Production of Antibody Fab Fragments in E. coli (David P. Humphreys and
Leigh Bowering). 28. Production of Human Therapeutic Monoclonal Antibodies
in Chicken Eggs (Lei Zhu and Robert J. Etches). 29. Production of
Antibodies in Plants (Kevin M. Cox, Jeffrey T. Regan, Jason D. Sterling,
Vincent P. M. Wingate, and Lynn F. Dickey). PART VIII THERAPEUTIC
ANTIBODIES. 30. The Formulation and Delivery of Monoclonal Antibodies
(Vikas K. Sharma, Hung-Wei Chih, Randall J. Mrsny, and Ann L. Daugherty).
31. Therapeutic Antibodies in Clinical Use and Leading Clinical Candidates
(Ningyan Zhang, Brent R. Williams, Ping Lu, Zhiqiang An, and Chen-Ni Chin).
32. Follow-On Protein Products: What, Where, When, How? (Brent R. Williams
and William R. Strohl). 33. Monomeric Fc Fusion Molecules (Jennifer A.
Dumont, Susan C. Low, Robert T. Peters, and Alan J. Bitonti). 34.
Radioimmunotherapy: Current Status and Future Directions (Neeta
Pandit-Taskar and Chaitanya R. Divgi). 35. Antibody-Drug Conjugate Therapy
(Stephen C. Alley, Dennis Benjamin, and Che-Leung Law). ABBREVIATIONS.
INDEX.